Research output: Contribution to journal › Article › peer-review
Effect of Microwave Irradiation on Arabinogalactan and Its Interaction with Betulin Diacetate. / Malyar, Yu N.; Mikhailenko, M. A.; Pankrushina, N. A. et al.
In: Russian Journal of Bioorganic Chemistry, Vol. 44, No. 7, 7, 01.12.2018, p. 870-875.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Effect of Microwave Irradiation on Arabinogalactan and Its Interaction with Betulin Diacetate
AU - Malyar, Yu N.
AU - Mikhailenko, M. A.
AU - Pankrushina, N. A.
AU - Mikheev, A. N.
AU - Kuznetsova, S. A.
AU - Shakhtshneider, T. P.
N1 - Funding Information: This study was supported by the Russian Foundation for Basic Research, the Government of the Kras-noyarsk krai the Krasnoyarsk Territorial Fund for Support of Scientific and Technological Activities within the framework of the scientific project no. 16-43-242083. Publisher Copyright: © 2018, Pleiades Publishing, Ltd.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Betulin diacetate (BDA) has a variety of biological activities, but poor solubility in water limits its application. The use of arabinogalactan (AG) as a complexing agent is a promising method for solving the problem of solubilization of drugs. In this study, effect of microwave (MW) irradiation on the properties of AG and BDA and their interaction in aqueous suspension with the formation of a water-soluble supramolecular complex was studied. It is shown that the microwave heating of AG under harsh conditions can lead to degradation of the biopolymer. The use of microwave heating could significantly reduce the complex preparation time compared to the conventional synthesis in a water bath. The preliminary mechanical treatment of the mixture of components, leading to the formation of mechanocomposites, inhibited the reaction between the components in the aqueous suspension under microwave irradiation. The IR spectroscopy method has shown that a supramolecular complex formed under microwave irradiation similar to that formed by conventional heating. The BDA-AG complex was isolated from a microwave heated solution as a thin film, which may be a promising material for pharmaceutical applications.
AB - Betulin diacetate (BDA) has a variety of biological activities, but poor solubility in water limits its application. The use of arabinogalactan (AG) as a complexing agent is a promising method for solving the problem of solubilization of drugs. In this study, effect of microwave (MW) irradiation on the properties of AG and BDA and their interaction in aqueous suspension with the formation of a water-soluble supramolecular complex was studied. It is shown that the microwave heating of AG under harsh conditions can lead to degradation of the biopolymer. The use of microwave heating could significantly reduce the complex preparation time compared to the conventional synthesis in a water bath. The preliminary mechanical treatment of the mixture of components, leading to the formation of mechanocomposites, inhibited the reaction between the components in the aqueous suspension under microwave irradiation. The IR spectroscopy method has shown that a supramolecular complex formed under microwave irradiation similar to that formed by conventional heating. The BDA-AG complex was isolated from a microwave heated solution as a thin film, which may be a promising material for pharmaceutical applications.
KW - arabinogalactan
KW - betulin diacetate
KW - complexation
KW - microwave irradiation
KW - solubility
UR - http://www.scopus.com/inward/record.url?scp=85061801971&partnerID=8YFLogxK
UR - https://elibrary.ru/item.asp?id=38641439
U2 - 10.1134/S1068162018070075
DO - 10.1134/S1068162018070075
M3 - Article
AN - SCOPUS:85061801971
VL - 44
SP - 870
EP - 875
JO - Russian Journal of Bioorganic Chemistry
JF - Russian Journal of Bioorganic Chemistry
SN - 1068-1620
IS - 7
M1 - 7
ER -
ID: 41222867