TY - JOUR

T1 - Effect of Microwave Irradiation on Arabinogalactan and Its Interaction with Betulin Diacetate

AU - Malyar, Yu N.

AU - Mikhailenko, M. A.

AU - Pankrushina, N. A.

AU - Mikheev, A. N.

AU - Kuznetsova, S. A.

AU - Shakhtshneider, T. P.

N1 - Funding Information: This study was supported by the Russian Foundation for Basic Research, the Government of the Kras-noyarsk krai the Krasnoyarsk Territorial Fund for Support of Scientific and Technological Activities within the framework of the scientific project no. 16-43-242083. Publisher Copyright: © 2018, Pleiades Publishing, Ltd.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Betulin diacetate (BDA) has a variety of biological activities, but poor solubility in water limits its application. The use of arabinogalactan (AG) as a complexing agent is a promising method for solving the problem of solubilization of drugs. In this study, effect of microwave (MW) irradiation on the properties of AG and BDA and their interaction in aqueous suspension with the formation of a water-soluble supramolecular complex was studied. It is shown that the microwave heating of AG under harsh conditions can lead to degradation of the biopolymer. The use of microwave heating could significantly reduce the complex preparation time compared to the conventional synthesis in a water bath. The preliminary mechanical treatment of the mixture of components, leading to the formation of mechanocomposites, inhibited the reaction between the components in the aqueous suspension under microwave irradiation. The IR spectroscopy method has shown that a supramolecular complex formed under microwave irradiation similar to that formed by conventional heating. The BDA-AG complex was isolated from a microwave heated solution as a thin film, which may be a promising material for pharmaceutical applications.

AB - Betulin diacetate (BDA) has a variety of biological activities, but poor solubility in water limits its application. The use of arabinogalactan (AG) as a complexing agent is a promising method for solving the problem of solubilization of drugs. In this study, effect of microwave (MW) irradiation on the properties of AG and BDA and their interaction in aqueous suspension with the formation of a water-soluble supramolecular complex was studied. It is shown that the microwave heating of AG under harsh conditions can lead to degradation of the biopolymer. The use of microwave heating could significantly reduce the complex preparation time compared to the conventional synthesis in a water bath. The preliminary mechanical treatment of the mixture of components, leading to the formation of mechanocomposites, inhibited the reaction between the components in the aqueous suspension under microwave irradiation. The IR spectroscopy method has shown that a supramolecular complex formed under microwave irradiation similar to that formed by conventional heating. The BDA-AG complex was isolated from a microwave heated solution as a thin film, which may be a promising material for pharmaceutical applications.

KW - arabinogalactan

KW - betulin diacetate

KW - complexation

KW - microwave irradiation

KW - solubility

UR - http://www.scopus.com/inward/record.url?scp=85061801971&partnerID=8YFLogxK

UR - https://elibrary.ru/item.asp?id=38641439

U2 - 10.1134/S1068162018070075

DO - 10.1134/S1068162018070075

M3 - Article

AN - SCOPUS:85061801971

VL - 44

SP - 870

EP - 875

JO - Russian Journal of Bioorganic Chemistry

JF - Russian Journal of Bioorganic Chemistry

SN - 1068-1620

IS - 7

M1 - 7

ER -