Three-dimensional simulation of the Caenorhabditis elegans body and muscle cells in liquid and gel environments for behavioural analysis

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Three-dimensional simulation of the Caenorhabditis elegans body and muscle cells in liquid and gel environments for behavioural analysis. / Palyanov, Andrey ; Khayrulin, Sergey; Larson, Stephen D.

In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 373, No. 1758, 20170376, 10.09.2018.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{d7325207439b44c18fa18f0087552a91,

title = "Three-dimensional simulation of the Caenorhabditis elegans body and muscle cells in liquid and gel environments for behavioural analysis",

abstract = "To better understand how a nervous system controls the movements of an organism, we have created a three-dimensional computational biomechanical model of the Caenorhabditis elegans body based on real anatomical structure. The body model is created with a particle system-based simulation engine known as Sibernetic,which implements thesmoothed particle-hydrodynamics algorithm. The model includes an elastic body-wall cuticle subject to hydrostatic pressure. This cuticle is then driven by body-wall muscle cells that contract and relax, whose positions and shape are mapped from C. Elegans anatomy, and determined from light microscopy and electron micrograph data. We show that by using different muscle activation patterns, this model is capable of producing C. Elegans-like behaviours, including crawling and swimming locomotion in environments with different viscosities, while fitting multiple additional known biomechanical properties of the animal. This article is part of a discussion meeting issue 'Connectome to behaviour: modelling C. Elegans at cellular resolution'.",

keywords = "Caenorhabditis elegans, Crawling, OpenWorm, Sibernetic, Simulation, Swimming, Locomotion/physiology, Computational Biology, Hydrodynamics, Hydrostatic Pressure, Biomechanical Phenomena, Animals, Models, Biological, Caenorhabditis elegans/physiology, LOW-REYNOLDS-NUMBER, SYSTEM, simulation, UNDULATORY LOCOMOTION, swimming, ADAPTATION, FORCES, C.-ELEGANS, GAIT, WORM, crawling",

author = "Andrey Palyanov and Sergey Khayrulin and Larson, {Stephen D.}",

note = "{\textcopyright} 2018 The Author(s).",

year = "2018",

month = sep,

day = "10",

doi = "10.1098/rstb.2017.0376",

language = "English",

volume = "373",

journal = "Philosophical Transactions of the Royal Society B: Biological Sciences",

issn = "0800-4622",

publisher = "The Royal Society",

number = "1758",

}

RIS

TY - JOUR

T1 - Three-dimensional simulation of the Caenorhabditis elegans body and muscle cells in liquid and gel environments for behavioural analysis

AU - Palyanov, Andrey

AU - Khayrulin, Sergey

AU - Larson, Stephen D.

PY - 2018/9/10

Y1 - 2018/9/10

N2 - To better understand how a nervous system controls the movements of an organism, we have created a three-dimensional computational biomechanical model of the Caenorhabditis elegans body based on real anatomical structure. The body model is created with a particle system-based simulation engine known as Sibernetic,which implements thesmoothed particle-hydrodynamics algorithm. The model includes an elastic body-wall cuticle subject to hydrostatic pressure. This cuticle is then driven by body-wall muscle cells that contract and relax, whose positions and shape are mapped from C. Elegans anatomy, and determined from light microscopy and electron micrograph data. We show that by using different muscle activation patterns, this model is capable of producing C. Elegans-like behaviours, including crawling and swimming locomotion in environments with different viscosities, while fitting multiple additional known biomechanical properties of the animal. This article is part of a discussion meeting issue 'Connectome to behaviour: modelling C. Elegans at cellular resolution'.

AB - To better understand how a nervous system controls the movements of an organism, we have created a three-dimensional computational biomechanical model of the Caenorhabditis elegans body based on real anatomical structure. The body model is created with a particle system-based simulation engine known as Sibernetic,which implements thesmoothed particle-hydrodynamics algorithm. The model includes an elastic body-wall cuticle subject to hydrostatic pressure. This cuticle is then driven by body-wall muscle cells that contract and relax, whose positions and shape are mapped from C. Elegans anatomy, and determined from light microscopy and electron micrograph data. We show that by using different muscle activation patterns, this model is capable of producing C. Elegans-like behaviours, including crawling and swimming locomotion in environments with different viscosities, while fitting multiple additional known biomechanical properties of the animal. This article is part of a discussion meeting issue 'Connectome to behaviour: modelling C. Elegans at cellular resolution'.

KW - Caenorhabditis elegans

KW - Crawling

KW - OpenWorm

KW - Sibernetic

KW - Simulation

KW - Swimming

KW - Locomotion/physiology

KW - Computational Biology

KW - Hydrodynamics

KW - Hydrostatic Pressure

KW - Biomechanical Phenomena

KW - Animals

KW - Models, Biological

KW - Caenorhabditis elegans/physiology

KW - LOW-REYNOLDS-NUMBER

KW - SYSTEM

KW - simulation

KW - UNDULATORY LOCOMOTION

KW - swimming

KW - ADAPTATION

KW - FORCES

KW - C.-ELEGANS

KW - GAIT

KW - WORM

KW - crawling

UR - http://www.scopus.com/inward/record.url?scp=85054070268&partnerID=8YFLogxK

U2 - 10.1098/rstb.2017.0376

DO - 10.1098/rstb.2017.0376

M3 - Article

C2 - 30201840

AN - SCOPUS:85054070268

VL - 373

JO - Philosophical Transactions of the Royal Society B: Biological Sciences

JF - Philosophical Transactions of the Royal Society B: Biological Sciences

SN - 0800-4622

IS - 1758

M1 - 20170376

ER -

ID: 16947231