Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Three-dimensional simulation of the Caenorhabditis elegans body and muscle cells in liquid and gel environments for behavioural analysis. / Palyanov, Andrey; Khayrulin, Sergey; Larson, Stephen D.
в: Philosophical Transactions of the Royal Society B: Biological Sciences, Том 373, № 1758, 20170376, 10.09.2018.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
}
TY - JOUR
T1 - Three-dimensional simulation of the Caenorhabditis elegans body and muscle cells in liquid and gel environments for behavioural analysis
AU - Palyanov, Andrey
AU - Khayrulin, Sergey
AU - Larson, Stephen D.
N1 - © 2018 The Author(s).
PY - 2018/9/10
Y1 - 2018/9/10
N2 - To better understand how a nervous system controls the movements of an organism, we have created a three-dimensional computational biomechanical model of the Caenorhabditis elegans body based on real anatomical structure. The body model is created with a particle system-based simulation engine known as Sibernetic,which implements thesmoothed particle-hydrodynamics algorithm. The model includes an elastic body-wall cuticle subject to hydrostatic pressure. This cuticle is then driven by body-wall muscle cells that contract and relax, whose positions and shape are mapped from C. Elegans anatomy, and determined from light microscopy and electron micrograph data. We show that by using different muscle activation patterns, this model is capable of producing C. Elegans-like behaviours, including crawling and swimming locomotion in environments with different viscosities, while fitting multiple additional known biomechanical properties of the animal. This article is part of a discussion meeting issue 'Connectome to behaviour: modelling C. Elegans at cellular resolution'.
AB - To better understand how a nervous system controls the movements of an organism, we have created a three-dimensional computational biomechanical model of the Caenorhabditis elegans body based on real anatomical structure. The body model is created with a particle system-based simulation engine known as Sibernetic,which implements thesmoothed particle-hydrodynamics algorithm. The model includes an elastic body-wall cuticle subject to hydrostatic pressure. This cuticle is then driven by body-wall muscle cells that contract and relax, whose positions and shape are mapped from C. Elegans anatomy, and determined from light microscopy and electron micrograph data. We show that by using different muscle activation patterns, this model is capable of producing C. Elegans-like behaviours, including crawling and swimming locomotion in environments with different viscosities, while fitting multiple additional known biomechanical properties of the animal. This article is part of a discussion meeting issue 'Connectome to behaviour: modelling C. Elegans at cellular resolution'.
KW - Caenorhabditis elegans
KW - Crawling
KW - OpenWorm
KW - Sibernetic
KW - Simulation
KW - Swimming
KW - Locomotion/physiology
KW - Computational Biology
KW - Hydrodynamics
KW - Hydrostatic Pressure
KW - Biomechanical Phenomena
KW - Animals
KW - Models, Biological
KW - Caenorhabditis elegans/physiology
KW - LOW-REYNOLDS-NUMBER
KW - SYSTEM
KW - simulation
KW - UNDULATORY LOCOMOTION
KW - swimming
KW - ADAPTATION
KW - FORCES
KW - C.-ELEGANS
KW - GAIT
KW - WORM
KW - crawling
UR - http://www.scopus.com/inward/record.url?scp=85054070268&partnerID=8YFLogxK
U2 - 10.1098/rstb.2017.0376
DO - 10.1098/rstb.2017.0376
M3 - Article
C2 - 30201840
AN - SCOPUS:85054070268
VL - 373
JO - Philosophical Transactions of the Royal Society B: Biological Sciences
JF - Philosophical Transactions of the Royal Society B: Biological Sciences
SN - 0800-4622
IS - 1758
M1 - 20170376
ER -
ID: 16947231