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The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks. / Лощенова, Полина Сергеевна; Сергеева, Светлана Владимировна; Fletcher, Sally С. et al.

In: NAR Cancer, Vol. 2, No. 2, zcaa004, 01.06.2020.

Research output: Contribution to journal › Article › peer-review

Harvard

Лощенова, ПС, Сергеева, СВ, Fletcher, SС & Дианов, ГЛ 2020, 'The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks', NAR Cancer, vol. 2, no. 2, zcaa004. https://doi.org/10.1093/narcan/zcaa004

APA

Лощенова, П. С., Сергеева, С. В., Fletcher, S. С., & Дианов, Г. Л. (2020). The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks. NAR Cancer, 2(2), [zcaa004]. https://doi.org/10.1093/narcan/zcaa004

Vancouver

Лощенова ПС, Сергеева СВ, Fletcher SС, Дианов ГЛ. The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks. NAR Cancer. 2020 Jun 1;2(2):zcaa004. doi: 10.1093/narcan/zcaa004

Author

Лощенова, Полина Сергеевна ; Сергеева, Светлана Владимировна ; Fletcher, Sally С. et al. / The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks. In: NAR Cancer. 2020 ; Vol. 2, No. 2.

BibTeX

@article{0ead6dafa98e4f989335a5d4c357ba28,
title = "The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks",
abstract = "Maintenance of genome stability suppresses cancer and other human diseases and is critical for organism survival. Inevitably, during a life span, multiple DNA lesions can arise due to the inherent instability of DNA molecules or due to endogenous or exogenous DNA damaging factors. To avoid malignant transformation of cells with damaged DNA, multiple mechanisms have evolved to repair DNA or to detect and eradicate cells accumulating unrepaired DNA damage. In this review, we discuss recent findings on the role of Sp1 (specificity factor 1) in the detection and elimination of cells accumulating persistent DNA strand breaks. We also discuss how this mechanism may contribute to the maintenance of physiological populations of healthy cells in an organism, thus preventing cancer formation, and the possible application of these findings in cancer therapy.",
author = "Лощенова, {Полина Сергеевна} and Сергеева, {Светлана Владимировна} and Fletcher, {Sally С.} and Дианов, {Григорий Леонидович}",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2020. Published by Oxford University Press on behalf of NAR Cancer.",
year = "2020",
month = jun,
day = "1",
doi = "10.1093/narcan/zcaa004",
language = "English",
volume = "2",
journal = "NAR Cancer",
issn = "2632-8674",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks

AU - Лощенова, Полина Сергеевна

AU - Сергеева, Светлана Владимировна

AU - Fletcher, Sally С.

AU - Дианов, Григорий Леонидович

N1 - Publisher Copyright: © The Author(s) 2020. Published by Oxford University Press on behalf of NAR Cancer.

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Maintenance of genome stability suppresses cancer and other human diseases and is critical for organism survival. Inevitably, during a life span, multiple DNA lesions can arise due to the inherent instability of DNA molecules or due to endogenous or exogenous DNA damaging factors. To avoid malignant transformation of cells with damaged DNA, multiple mechanisms have evolved to repair DNA or to detect and eradicate cells accumulating unrepaired DNA damage. In this review, we discuss recent findings on the role of Sp1 (specificity factor 1) in the detection and elimination of cells accumulating persistent DNA strand breaks. We also discuss how this mechanism may contribute to the maintenance of physiological populations of healthy cells in an organism, thus preventing cancer formation, and the possible application of these findings in cancer therapy.

AB - Maintenance of genome stability suppresses cancer and other human diseases and is critical for organism survival. Inevitably, during a life span, multiple DNA lesions can arise due to the inherent instability of DNA molecules or due to endogenous or exogenous DNA damaging factors. To avoid malignant transformation of cells with damaged DNA, multiple mechanisms have evolved to repair DNA or to detect and eradicate cells accumulating unrepaired DNA damage. In this review, we discuss recent findings on the role of Sp1 (specificity factor 1) in the detection and elimination of cells accumulating persistent DNA strand breaks. We also discuss how this mechanism may contribute to the maintenance of physiological populations of healthy cells in an organism, thus preventing cancer formation, and the possible application of these findings in cancer therapy.

UR - http://www.scopus.com/inward/record.url?scp=85113199101&partnerID=8YFLogxK

U2 - 10.1093/narcan/zcaa004

DO - 10.1093/narcan/zcaa004

M3 - Article

C2 - 34316684

VL - 2

JO - NAR Cancer

JF - NAR Cancer

SN - 2632-8674

IS - 2

M1 - zcaa004

ER -

ID: 26155958