Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks. / Лощенова, Полина Сергеевна; Сергеева, Светлана Владимировна; Fletcher, Sally С. и др.
в: NAR Cancer, Том 2, № 2, zcaa004, 01.06.2020.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks
AU - Лощенова, Полина Сергеевна
AU - Сергеева, Светлана Владимировна
AU - Fletcher, Sally С.
AU - Дианов, Григорий Леонидович
N1 - Publisher Copyright: © The Author(s) 2020. Published by Oxford University Press on behalf of NAR Cancer.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Maintenance of genome stability suppresses cancer and other human diseases and is critical for organism survival. Inevitably, during a life span, multiple DNA lesions can arise due to the inherent instability of DNA molecules or due to endogenous or exogenous DNA damaging factors. To avoid malignant transformation of cells with damaged DNA, multiple mechanisms have evolved to repair DNA or to detect and eradicate cells accumulating unrepaired DNA damage. In this review, we discuss recent findings on the role of Sp1 (specificity factor 1) in the detection and elimination of cells accumulating persistent DNA strand breaks. We also discuss how this mechanism may contribute to the maintenance of physiological populations of healthy cells in an organism, thus preventing cancer formation, and the possible application of these findings in cancer therapy.
AB - Maintenance of genome stability suppresses cancer and other human diseases and is critical for organism survival. Inevitably, during a life span, multiple DNA lesions can arise due to the inherent instability of DNA molecules or due to endogenous or exogenous DNA damaging factors. To avoid malignant transformation of cells with damaged DNA, multiple mechanisms have evolved to repair DNA or to detect and eradicate cells accumulating unrepaired DNA damage. In this review, we discuss recent findings on the role of Sp1 (specificity factor 1) in the detection and elimination of cells accumulating persistent DNA strand breaks. We also discuss how this mechanism may contribute to the maintenance of physiological populations of healthy cells in an organism, thus preventing cancer formation, and the possible application of these findings in cancer therapy.
UR - http://www.scopus.com/inward/record.url?scp=85113199101&partnerID=8YFLogxK
U2 - 10.1093/narcan/zcaa004
DO - 10.1093/narcan/zcaa004
M3 - Article
C2 - 34316684
VL - 2
JO - NAR Cancer
JF - NAR Cancer
SN - 2632-8674
IS - 2
M1 - zcaa004
ER -
ID: 26155958