Research output: Contribution to journal › Article › peer-review
The effect of host genetics on the gut microbiome. / Bonder, Marc Jan; Kurilshikov, Alexander; Tigchelaar, Ettje F. et al.
In: Nature Genetics, Vol. 48, No. 11, 8, 01.11.2016, p. 1407-1412.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - The effect of host genetics on the gut microbiome
AU - Bonder, Marc Jan
AU - Kurilshikov, Alexander
AU - Tigchelaar, Ettje F.
AU - Mujagic, Zlatan
AU - Imhann, Floris
AU - Vila, Arnau Vich
AU - Deelen, Patrick
AU - Vatanen, Tommi
AU - Schirmer, Melanie
AU - Smeekens, Sanne P.
AU - Zhernakova, Daria V.
AU - Jankipersadsing, Soesma A.
AU - Jaeger, Martin
AU - Oosting, Marije
AU - Cenit, Maria Carmen
AU - Masclee, Ad A.M.
AU - Swertz, Morris A.
AU - Li, Yang
AU - Kumar, Vinod
AU - Joosten, Leo
AU - Harmsen, Hermie
AU - Weersma, Rinse K.
AU - Franke, Lude
AU - Hofker, Marten H.
AU - Xavier, Ramnik J.
AU - Jonkers, Daisy
AU - Netea, Mihai G.
AU - Wijmenga, Cisca
AU - Fu, Jingyuan
AU - Zhernakova, Alexandra
N1 - Publisher Copyright: © 2016 Nature America, Inc., part of Springer Nature. All rights reserved.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - The gut microbiome is affected by multiple factors, including genetics. In this study, we assessed the influence of host genetics on microbial species, pathways and gene ontology categories, on the basis of metagenomic sequencing in 1,514 subjects. In a genome-wide analysis, we identified associations of 9 loci with microbial taxonomies and 33 loci with microbial pathways and gene ontology terms at P < 5 × 10 â '8. Additionally, in a targeted analysis of regions involved in complex diseases, innate and adaptive immunity, or food preferences, 32 loci were identified at the suggestive level of P < 5 × 10 â '6. Most of our reported associations are new, including genome-wide significance for the C-type lectin molecules CLEC4F-CD207 at 2p13.3 and CLEC4A-FAM90A1 at 12p13. We also identified association of a functional LCT SNP with the Bifidobacterium genus (P = 3.45 × 10 â '8) and provide evidence of a gene-diet interaction in the regulation of Bifidobacterium abundance. Our results demonstrate the importance of understanding host-microbe interactions to gain better insight into human health.
AB - The gut microbiome is affected by multiple factors, including genetics. In this study, we assessed the influence of host genetics on microbial species, pathways and gene ontology categories, on the basis of metagenomic sequencing in 1,514 subjects. In a genome-wide analysis, we identified associations of 9 loci with microbial taxonomies and 33 loci with microbial pathways and gene ontology terms at P < 5 × 10 â '8. Additionally, in a targeted analysis of regions involved in complex diseases, innate and adaptive immunity, or food preferences, 32 loci were identified at the suggestive level of P < 5 × 10 â '6. Most of our reported associations are new, including genome-wide significance for the C-type lectin molecules CLEC4F-CD207 at 2p13.3 and CLEC4A-FAM90A1 at 12p13. We also identified association of a functional LCT SNP with the Bifidobacterium genus (P = 3.45 × 10 â '8) and provide evidence of a gene-diet interaction in the regulation of Bifidobacterium abundance. Our results demonstrate the importance of understanding host-microbe interactions to gain better insight into human health.
UR - http://www.scopus.com/inward/record.url?scp=84989832355&partnerID=8YFLogxK
UR - https://www.elibrary.ru/item.asp?id=27571170
U2 - 10.1038/ng.3663
DO - 10.1038/ng.3663
M3 - Article
C2 - 27694959
AN - SCOPUS:84989832355
VL - 48
SP - 1407
EP - 1412
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 11
M1 - 8
ER -
ID: 34660083