The effect of host genetics on the gut microbiome › Обзор исследований

Standard

The effect of host genetics on the gut microbiome. / Bonder, Marc Jan; Kurilshikov, Alexander; Tigchelaar, Ettje F. и др.

в: Nature Genetics, Том 48, № 11, 8, 01.11.2016, стр. 1407-1412.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Bonder, MJ, Kurilshikov, A, Tigchelaar, EF, Mujagic, Z, Imhann, F, Vila, AV, Deelen, P, Vatanen, T, Schirmer, M, Smeekens, SP, Zhernakova, DV, Jankipersadsing, SA, Jaeger, M, Oosting, M, Cenit, MC, Masclee, AAM, Swertz, MA, Li, Y, Kumar, V, Joosten, L, Harmsen, H, Weersma, RK, Franke, L, Hofker, MH, Xavier, RJ, Jonkers, D, Netea, MG, Wijmenga, C, Fu, J & Zhernakova, A 2016, 'The effect of host genetics on the gut microbiome', Nature Genetics, Том. 48, № 11, 8, стр. 1407-1412. https://doi.org/10.1038/ng.3663

APA

Bonder, M. J., Kurilshikov, A., Tigchelaar, E. F., Mujagic, Z., Imhann, F., Vila, A. V., Deelen, P., Vatanen, T., Schirmer, M., Smeekens, S. P., Zhernakova, D. V., Jankipersadsing, S. A., Jaeger, M., Oosting, M., Cenit, M. C., Masclee, A. A. M., Swertz, M. A., Li, Y., Kumar, V., ... Zhernakova, A. (2016). The effect of host genetics on the gut microbiome. Nature Genetics, 48(11), 1407-1412. [8]. https://doi.org/10.1038/ng.3663

Vancouver

Bonder MJ, Kurilshikov A, Tigchelaar EF, Mujagic Z, Imhann F, Vila AV и др. The effect of host genetics on the gut microbiome. Nature Genetics. 2016 нояб. 1;48(11):1407-1412. 8. doi: 10.1038/ng.3663

Author

Bonder, Marc Jan ; Kurilshikov, Alexander ; Tigchelaar, Ettje F. и др. / The effect of host genetics on the gut microbiome. в: Nature Genetics. 2016 ; Том 48, № 11. стр. 1407-1412.

BibTeX

@article{dc6b00564cec497aa52c17a83b50bdab,

title = "The effect of host genetics on the gut microbiome",

abstract = "The gut microbiome is affected by multiple factors, including genetics. In this study, we assessed the influence of host genetics on microbial species, pathways and gene ontology categories, on the basis of metagenomic sequencing in 1,514 subjects. In a genome-wide analysis, we identified associations of 9 loci with microbial taxonomies and 33 loci with microbial pathways and gene ontology terms at P < 5 × 10 {\^a} '8. Additionally, in a targeted analysis of regions involved in complex diseases, innate and adaptive immunity, or food preferences, 32 loci were identified at the suggestive level of P < 5 × 10 {\^a} '6. Most of our reported associations are new, including genome-wide significance for the C-type lectin molecules CLEC4F-CD207 at 2p13.3 and CLEC4A-FAM90A1 at 12p13. We also identified association of a functional LCT SNP with the Bifidobacterium genus (P = 3.45 × 10 {\^a} '8) and provide evidence of a gene-diet interaction in the regulation of Bifidobacterium abundance. Our results demonstrate the importance of understanding host-microbe interactions to gain better insight into human health.",

author = "Bonder, {Marc Jan} and Alexander Kurilshikov and Tigchelaar, {Ettje F.} and Zlatan Mujagic and Floris Imhann and Vila, {Arnau Vich} and Patrick Deelen and Tommi Vatanen and Melanie Schirmer and Smeekens, {Sanne P.} and Zhernakova, {Daria V.} and Jankipersadsing, {Soesma A.} and Martin Jaeger and Marije Oosting and Cenit, {Maria Carmen} and Masclee, {Ad A.M.} and Swertz, {Morris A.} and Yang Li and Vinod Kumar and Leo Joosten and Hermie Harmsen and Weersma, {Rinse K.} and Lude Franke and Hofker, {Marten H.} and Xavier, {Ramnik J.} and Daisy Jonkers and Netea, {Mihai G.} and Cisca Wijmenga and Jingyuan Fu and Alexandra Zhernakova",

year = "2016",

month = nov,

day = "1",

doi = "10.1038/ng.3663",

language = "English",

volume = "48",

pages = "1407--1412",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "11",

}

RIS

TY - JOUR

T1 - The effect of host genetics on the gut microbiome

AU - Bonder, Marc Jan

AU - Kurilshikov, Alexander

AU - Tigchelaar, Ettje F.

AU - Mujagic, Zlatan

AU - Imhann, Floris

AU - Vila, Arnau Vich

AU - Deelen, Patrick

AU - Vatanen, Tommi

AU - Schirmer, Melanie

AU - Smeekens, Sanne P.

AU - Zhernakova, Daria V.

AU - Jankipersadsing, Soesma A.

AU - Jaeger, Martin

AU - Oosting, Marije

AU - Cenit, Maria Carmen

AU - Masclee, Ad A.M.

AU - Swertz, Morris A.

AU - Li, Yang

AU - Kumar, Vinod

AU - Joosten, Leo

AU - Harmsen, Hermie

AU - Weersma, Rinse K.

AU - Franke, Lude

AU - Hofker, Marten H.

AU - Xavier, Ramnik J.

AU - Jonkers, Daisy

AU - Netea, Mihai G.

AU - Wijmenga, Cisca

AU - Fu, Jingyuan

AU - Zhernakova, Alexandra

PY - 2016/11/1

Y1 - 2016/11/1

N2 - The gut microbiome is affected by multiple factors, including genetics. In this study, we assessed the influence of host genetics on microbial species, pathways and gene ontology categories, on the basis of metagenomic sequencing in 1,514 subjects. In a genome-wide analysis, we identified associations of 9 loci with microbial taxonomies and 33 loci with microbial pathways and gene ontology terms at P < 5 × 10 â '8. Additionally, in a targeted analysis of regions involved in complex diseases, innate and adaptive immunity, or food preferences, 32 loci were identified at the suggestive level of P < 5 × 10 â '6. Most of our reported associations are new, including genome-wide significance for the C-type lectin molecules CLEC4F-CD207 at 2p13.3 and CLEC4A-FAM90A1 at 12p13. We also identified association of a functional LCT SNP with the Bifidobacterium genus (P = 3.45 × 10 â '8) and provide evidence of a gene-diet interaction in the regulation of Bifidobacterium abundance. Our results demonstrate the importance of understanding host-microbe interactions to gain better insight into human health.

AB - The gut microbiome is affected by multiple factors, including genetics. In this study, we assessed the influence of host genetics on microbial species, pathways and gene ontology categories, on the basis of metagenomic sequencing in 1,514 subjects. In a genome-wide analysis, we identified associations of 9 loci with microbial taxonomies and 33 loci with microbial pathways and gene ontology terms at P < 5 × 10 â '8. Additionally, in a targeted analysis of regions involved in complex diseases, innate and adaptive immunity, or food preferences, 32 loci were identified at the suggestive level of P < 5 × 10 â '6. Most of our reported associations are new, including genome-wide significance for the C-type lectin molecules CLEC4F-CD207 at 2p13.3 and CLEC4A-FAM90A1 at 12p13. We also identified association of a functional LCT SNP with the Bifidobacterium genus (P = 3.45 × 10 â '8) and provide evidence of a gene-diet interaction in the regulation of Bifidobacterium abundance. Our results demonstrate the importance of understanding host-microbe interactions to gain better insight into human health.

UR - http://www.scopus.com/inward/record.url?scp=84989832355&partnerID=8YFLogxK

UR - https://www.elibrary.ru/item.asp?id=27571170

U2 - 10.1038/ng.3663

DO - 10.1038/ng.3663

M3 - Article

C2 - 27694959

AN - SCOPUS:84989832355

VL - 48

SP - 1407

EP - 1412

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 11

M1 - 8

ER -

ID: 34660083