Research output: Contribution to journal › Article › peer-review
The effect of adding modified chitosan on the strength properties of bacterial cellulose for clinical applications. / Lipovka, Anna; Kharchenko, Alexey; Dubovoy, Andrey et al.
In: Polymers, Vol. 13, No. 12, 1995, 02.06.2021.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - The effect of adding modified chitosan on the strength properties of bacterial cellulose for clinical applications
AU - Lipovka, Anna
AU - Kharchenko, Alexey
AU - Dubovoy, Andrey
AU - Filipenko, Maxim
AU - Stupak, Vyacheslav
AU - Mayorov, Alexander
AU - Fomenko, Vladislav
AU - Geydt, Pavel
AU - Parshin, Daniil
N1 - Funding Information: Funding: A.L. and D.P. thank the Government of the Russian Federation (grant number 14.W03.31.0002) for providing the equipment and support for measuring the strength properties of cadaveric DM and BNC and analyzing measurement results; A.D. thanks the Russian Foundation for Basic Research (grant number 19-48-540010) for providing and mechanical testing fresh DM samples.
PY - 2021/6/2
Y1 - 2021/6/2
N2 - Currently, several materials for the closure of the dura mater (DM) defects are known. However, the long-term results of their usage reveal a number of disadvantages. The use of antibiotics and chitosan is one of the major trends in solving the problems associated with infectious after-operational complications. This work compares the mechanical properties of samples of bacterial nanocellulose (BNC) impregnated with Novochizol™ and vancomycin with native BNC and preserved and native human DM. An assessment of the possibility of controling the mechanical properties of these materials by changing their thickness has been performed by statistical analysis methods. A total of 80 specimens of comparable samples were investigated. During the analysis, the results obtained, the factor of Novochizol™ addition has provided a statistically significant impact on the strength properties (Fisher Criteria p-value 0.00509 for stress and 0.00112 for deformation). Moreover, a stronger relationship between the thickness of the samples and their ultimate load was shown: R2=0.236 for BNC + Novochizol™ + vancomycin, compared to R2=0.0405 for native BNC. Using factor analysis, it was possible to show a significant effect of modified chitosan (Novochizol™) on the ultimate stress (p-value = 0.005).
AB - Currently, several materials for the closure of the dura mater (DM) defects are known. However, the long-term results of their usage reveal a number of disadvantages. The use of antibiotics and chitosan is one of the major trends in solving the problems associated with infectious after-operational complications. This work compares the mechanical properties of samples of bacterial nanocellulose (BNC) impregnated with Novochizol™ and vancomycin with native BNC and preserved and native human DM. An assessment of the possibility of controling the mechanical properties of these materials by changing their thickness has been performed by statistical analysis methods. A total of 80 specimens of comparable samples were investigated. During the analysis, the results obtained, the factor of Novochizol™ addition has provided a statistically significant impact on the strength properties (Fisher Criteria p-value 0.00509 for stress and 0.00112 for deformation). Moreover, a stronger relationship between the thickness of the samples and their ultimate load was shown: R2=0.236 for BNC + Novochizol™ + vancomycin, compared to R2=0.0405 for native BNC. Using factor analysis, it was possible to show a significant effect of modified chitosan (Novochizol™) on the ultimate stress (p-value = 0.005).
KW - Bacterial nanocellulose
KW - Chitosan gel
KW - Dura matter
KW - Dura substitutes
KW - Factor analysis
KW - Novochizol™
KW - Tissue biomechanics
KW - Vancomycin
UR - http://www.scopus.com/inward/record.url?scp=85108682491&partnerID=8YFLogxK
U2 - 10.3390/polym13121995
DO - 10.3390/polym13121995
M3 - Article
C2 - 34207113
AN - SCOPUS:85108682491
VL - 13
JO - Polymers
JF - Polymers
SN - 2073-4360
IS - 12
M1 - 1995
ER -
ID: 29129460