TY - JOUR

T1 - The effect of adding modified chitosan on the strength properties of bacterial cellulose for clinical applications

AU - Lipovka, Anna

AU - Kharchenko, Alexey

AU - Dubovoy, Andrey

AU - Filipenko, Maxim

AU - Stupak, Vyacheslav

AU - Mayorov, Alexander

AU - Fomenko, Vladislav

AU - Geydt, Pavel

AU - Parshin, Daniil

N1 - Funding Information: Funding: A.L. and D.P. thank the Government of the Russian Federation (grant number 14.W03.31.0002) for providing the equipment and support for measuring the strength properties of cadaveric DM and BNC and analyzing measurement results; A.D. thanks the Russian Foundation for Basic Research (grant number 19-48-540010) for providing and mechanical testing fresh DM samples.

PY - 2021/6/2

Y1 - 2021/6/2

N2 - Currently, several materials for the closure of the dura mater (DM) defects are known. However, the long-term results of their usage reveal a number of disadvantages. The use of antibiotics and chitosan is one of the major trends in solving the problems associated with infectious after-operational complications. This work compares the mechanical properties of samples of bacterial nanocellulose (BNC) impregnated with Novochizol™ and vancomycin with native BNC and preserved and native human DM. An assessment of the possibility of controling the mechanical properties of these materials by changing their thickness has been performed by statistical analysis methods. A total of 80 specimens of comparable samples were investigated. During the analysis, the results obtained, the factor of Novochizol™ addition has provided a statistically significant impact on the strength properties (Fisher Criteria p-value 0.00509 for stress and 0.00112 for deformation). Moreover, a stronger relationship between the thickness of the samples and their ultimate load was shown: R2=0.236 for BNC + Novochizol™ + vancomycin, compared to R2=0.0405 for native BNC. Using factor analysis, it was possible to show a significant effect of modified chitosan (Novochizol™) on the ultimate stress (p-value = 0.005).

AB - Currently, several materials for the closure of the dura mater (DM) defects are known. However, the long-term results of their usage reveal a number of disadvantages. The use of antibiotics and chitosan is one of the major trends in solving the problems associated with infectious after-operational complications. This work compares the mechanical properties of samples of bacterial nanocellulose (BNC) impregnated with Novochizol™ and vancomycin with native BNC and preserved and native human DM. An assessment of the possibility of controling the mechanical properties of these materials by changing their thickness has been performed by statistical analysis methods. A total of 80 specimens of comparable samples were investigated. During the analysis, the results obtained, the factor of Novochizol™ addition has provided a statistically significant impact on the strength properties (Fisher Criteria p-value 0.00509 for stress and 0.00112 for deformation). Moreover, a stronger relationship between the thickness of the samples and their ultimate load was shown: R2=0.236 for BNC + Novochizol™ + vancomycin, compared to R2=0.0405 for native BNC. Using factor analysis, it was possible to show a significant effect of modified chitosan (Novochizol™) on the ultimate stress (p-value = 0.005).

KW - Bacterial nanocellulose

KW - Chitosan gel

KW - Dura matter

KW - Dura substitutes

KW - Factor analysis

KW - Novochizol™

KW - Tissue biomechanics

KW - Vancomycin

UR - http://www.scopus.com/inward/record.url?scp=85108682491&partnerID=8YFLogxK

U2 - 10.3390/polym13121995

DO - 10.3390/polym13121995

M3 - Article

C2 - 34207113

AN - SCOPUS:85108682491

VL - 13

JO - Polymers

JF - Polymers

SN - 2073-4360

IS - 12

M1 - 1995

ER -