Standard

Synthesis of d-(+)-camphor-based : N -acylhydrazones and their antiviral activity. / Kovaleva, Kseniya S.; Zubkov, Fedor I.; Bormotov, Nikolay I. et al.

In: MedChemComm, Vol. 9, No. 12, 01.12.2018, p. 2072-2082.

Research output: Contribution to journal › Article › peer-review

Harvard

Kovaleva, KS, Zubkov, FI, Bormotov, NI, Novikov, RA, Dorovatovskii, PV, Khrustalev, VN, Gatilov, YV, Zarubaev, VV, Yarovaya, OI, Shishkina, LN & Salakhutdinov, NF 2018, 'Synthesis of d-(+)-camphor-based: N -acylhydrazones and their antiviral activity', MedChemComm, vol. 9, no. 12, pp. 2072-2082. https://doi.org/10.1039/c8md00442k

APA

Kovaleva, K. S., Zubkov, F. I., Bormotov, N. I., Novikov, R. A., Dorovatovskii, P. V., Khrustalev, V. N., Gatilov, Y. V., Zarubaev, V. V., Yarovaya, O. I., Shishkina, L. N., & Salakhutdinov, N. F. (2018). Synthesis of d-(+)-camphor-based: N -acylhydrazones and their antiviral activity. MedChemComm, 9(12), 2072-2082. https://doi.org/10.1039/c8md00442k

Vancouver

Kovaleva KS, Zubkov FI, Bormotov NI, Novikov RA, Dorovatovskii PV, Khrustalev VN et al. Synthesis of d-(+)-camphor-based: N -acylhydrazones and their antiviral activity. MedChemComm. 2018 Dec 1;9(12):2072-2082. doi: 10.1039/c8md00442k

Author

Kovaleva, Kseniya S. ; Zubkov, Fedor I. ; Bormotov, Nikolay I. et al. / Synthesis of d-(+)-camphor-based : N -acylhydrazones and their antiviral activity. In: MedChemComm. 2018 ; Vol. 9, No. 12. pp. 2072-2082.

BibTeX

@article{d7a050ef287b4bb299421455c83060e8,
title = "Synthesis of d-(+)-camphor-based: N -acylhydrazones and their antiviral activity",
abstract = "The design and synthesis of a series of novel d-(+)-camphor N-acylhydrazones exhibiting inhibitory activity against vaccinia and influenza viruses are presented. An easy pathway to camphor-based N-acylhydrazones containing in their structure aliphatic, aromatic, and heterocyclic pharmacophore scaffolds has been developed. The conformation and configuration of the synthesized hydrazones were thoroughly characterized by a complete set of spectral characterization techniques, including 2D NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. In vitro screening for activity against vaccinia virus (VV) and influenza H1N1 virus was carried out for the obtained compounds. It was revealed that the derived N-acylhydrazones exhibited significant antiviral activity with a selectivity index >280 against VV for the most promising compound.",
keywords = "AGENTS, BORNEOL DERIVATIVES, CIDOFOVIR, COMPOUND, IN-VITRO, INFLUENZA, INHIBITORS, RESISTANCE, VIRUSES",
author = "Kovaleva, {Kseniya S.} and Zubkov, {Fedor I.} and Bormotov, {Nikolay I.} and Novikov, {Roman A.} and Dorovatovskii, {Pavel V.} and Khrustalev, {Victor N.} and Gatilov, {Yuriy V.} and Zarubaev, {Vladimir V.} and Yarovaya, {Olga I.} and Shishkina, {Larisa N.} and Salakhutdinov, {Nariman F.}",
year = "2018",
month = dec,
day = "1",
doi = "10.1039/c8md00442k",
language = "English",
volume = "9",
pages = "2072--2082",
journal = "MedChemComm",
issn = "2040-2503",
publisher = "Royal Society of Chemistry",
number = "12",

}

RIS

TY - JOUR

T1 - Synthesis of d-(+)-camphor-based

T2 - N -acylhydrazones and their antiviral activity

AU - Kovaleva, Kseniya S.

AU - Zubkov, Fedor I.

AU - Bormotov, Nikolay I.

AU - Novikov, Roman A.

AU - Dorovatovskii, Pavel V.

AU - Khrustalev, Victor N.

AU - Gatilov, Yuriy V.

AU - Zarubaev, Vladimir V.

AU - Yarovaya, Olga I.

AU - Shishkina, Larisa N.

AU - Salakhutdinov, Nariman F.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The design and synthesis of a series of novel d-(+)-camphor N-acylhydrazones exhibiting inhibitory activity against vaccinia and influenza viruses are presented. An easy pathway to camphor-based N-acylhydrazones containing in their structure aliphatic, aromatic, and heterocyclic pharmacophore scaffolds has been developed. The conformation and configuration of the synthesized hydrazones were thoroughly characterized by a complete set of spectral characterization techniques, including 2D NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. In vitro screening for activity against vaccinia virus (VV) and influenza H1N1 virus was carried out for the obtained compounds. It was revealed that the derived N-acylhydrazones exhibited significant antiviral activity with a selectivity index >280 against VV for the most promising compound.

AB - The design and synthesis of a series of novel d-(+)-camphor N-acylhydrazones exhibiting inhibitory activity against vaccinia and influenza viruses are presented. An easy pathway to camphor-based N-acylhydrazones containing in their structure aliphatic, aromatic, and heterocyclic pharmacophore scaffolds has been developed. The conformation and configuration of the synthesized hydrazones were thoroughly characterized by a complete set of spectral characterization techniques, including 2D NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. In vitro screening for activity against vaccinia virus (VV) and influenza H1N1 virus was carried out for the obtained compounds. It was revealed that the derived N-acylhydrazones exhibited significant antiviral activity with a selectivity index >280 against VV for the most promising compound.

KW - AGENTS

KW - BORNEOL DERIVATIVES

KW - CIDOFOVIR

KW - COMPOUND

KW - IN-VITRO

KW - INFLUENZA

KW - INHIBITORS

KW - RESISTANCE

KW - VIRUSES

UR - http://www.scopus.com/inward/record.url?scp=85058669078&partnerID=8YFLogxK

U2 - 10.1039/c8md00442k

DO - 10.1039/c8md00442k

M3 - Article

C2 - 30746065

AN - SCOPUS:85058669078

VL - 9

SP - 2072

EP - 2082

JO - MedChemComm

JF - MedChemComm

SN - 2040-2503

IS - 12

ER -

ID: 17878757