Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Synthesis of d-(+)-camphor-based : N -acylhydrazones and their antiviral activity. / Kovaleva, Kseniya S.; Zubkov, Fedor I.; Bormotov, Nikolay I. и др.
в: MedChemComm, Том 9, № 12, 01.12.2018, стр. 2072-2082.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Synthesis of d-(+)-camphor-based
T2 - N -acylhydrazones and their antiviral activity
AU - Kovaleva, Kseniya S.
AU - Zubkov, Fedor I.
AU - Bormotov, Nikolay I.
AU - Novikov, Roman A.
AU - Dorovatovskii, Pavel V.
AU - Khrustalev, Victor N.
AU - Gatilov, Yuriy V.
AU - Zarubaev, Vladimir V.
AU - Yarovaya, Olga I.
AU - Shishkina, Larisa N.
AU - Salakhutdinov, Nariman F.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - The design and synthesis of a series of novel d-(+)-camphor N-acylhydrazones exhibiting inhibitory activity against vaccinia and influenza viruses are presented. An easy pathway to camphor-based N-acylhydrazones containing in their structure aliphatic, aromatic, and heterocyclic pharmacophore scaffolds has been developed. The conformation and configuration of the synthesized hydrazones were thoroughly characterized by a complete set of spectral characterization techniques, including 2D NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. In vitro screening for activity against vaccinia virus (VV) and influenza H1N1 virus was carried out for the obtained compounds. It was revealed that the derived N-acylhydrazones exhibited significant antiviral activity with a selectivity index >280 against VV for the most promising compound.
AB - The design and synthesis of a series of novel d-(+)-camphor N-acylhydrazones exhibiting inhibitory activity against vaccinia and influenza viruses are presented. An easy pathway to camphor-based N-acylhydrazones containing in their structure aliphatic, aromatic, and heterocyclic pharmacophore scaffolds has been developed. The conformation and configuration of the synthesized hydrazones were thoroughly characterized by a complete set of spectral characterization techniques, including 2D NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. In vitro screening for activity against vaccinia virus (VV) and influenza H1N1 virus was carried out for the obtained compounds. It was revealed that the derived N-acylhydrazones exhibited significant antiviral activity with a selectivity index >280 against VV for the most promising compound.
KW - AGENTS
KW - BORNEOL DERIVATIVES
KW - CIDOFOVIR
KW - COMPOUND
KW - IN-VITRO
KW - INFLUENZA
KW - INHIBITORS
KW - RESISTANCE
KW - VIRUSES
UR - http://www.scopus.com/inward/record.url?scp=85058669078&partnerID=8YFLogxK
U2 - 10.1039/c8md00442k
DO - 10.1039/c8md00442k
M3 - Article
C2 - 30746065
AN - SCOPUS:85058669078
VL - 9
SP - 2072
EP - 2082
JO - MedChemComm
JF - MedChemComm
SN - 2040-2503
IS - 12
ER -
ID: 17878757