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Studying ALS: Current Approaches, Effect on Potential Treatment Strategy. / Ustyantseva, E. I.; Medvedev, S. P.; Zakian, S. M.

Mechanisms of Genome Protection and Repair. ed. / Dmitry O. Zharkov. Vol. 1241 Springer, Cham, 2020. p. 195-217 (Advances in experimental medicine and biology).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review

Harvard

Ustyantseva, EI, Medvedev, SP & Zakian, SM 2020, Studying ALS: Current Approaches, Effect on Potential Treatment Strategy. in DO Zharkov (ed.), Mechanisms of Genome Protection and Repair. vol. 1241, Advances in experimental medicine and biology, Springer, Cham, pp. 195-217. https://doi.org/10.1007/978-3-030-41283-8_11

APA

Ustyantseva, E. I., Medvedev, S. P., & Zakian, S. M. (2020). Studying ALS: Current Approaches, Effect on Potential Treatment Strategy. In D. O. Zharkov (Ed.), Mechanisms of Genome Protection and Repair (Vol. 1241, pp. 195-217). (Advances in experimental medicine and biology). Springer, Cham. https://doi.org/10.1007/978-3-030-41283-8_11

Vancouver

Ustyantseva EI, Medvedev SP, Zakian SM. Studying ALS: Current Approaches, Effect on Potential Treatment Strategy. In Zharkov DO, editor, Mechanisms of Genome Protection and Repair. Vol. 1241. Springer, Cham. 2020. p. 195-217. (Advances in experimental medicine and biology). doi: 10.1007/978-3-030-41283-8_11

Author

Ustyantseva, E. I. ; Medvedev, S. P. ; Zakian, S. M. / Studying ALS: Current Approaches, Effect on Potential Treatment Strategy. Mechanisms of Genome Protection and Repair. editor / Dmitry O. Zharkov. Vol. 1241 Springer, Cham, 2020. pp. 195-217 (Advances in experimental medicine and biology).

BibTeX

@inbook{0d846c21bb004733979e689e2100f151,
title = "Studying ALS: Current Approaches, Effect on Potential Treatment Strategy",
abstract = "Amyotrophic lateral sclerosis (ALS) is one of the most common neurodegenerative diseases, characterized by inevitable progressive paralysis. To date, only two disease modifying therapeutic options are available for the patients with ALS, although they show very modest effect on disease course. The main reason of failure in the field of pharmacological correction of ALS is inability to untangle complex relationships taking place during ALS initiation and progression. Traditional methods of research, based on morphology or transgenic animal models studying provided lots of information about ALS throughout the years. However, translation of these results to humans was unsuccessful due to incomplete recapitulation of molecular pathology and overall inadequacy of the models used in the research.In this review we summarize current knowledge regarding ALS molecular pathology with depiction of novel methods applied recently for the studies. Furthermore we describe present and potential treatment strategies that are based on the recent findings in ALS disease mechanisms.",
keywords = "ALS, Amyotrophic lateral sclerosis, Disease mechanisms, Animals, Humans, Amyotrophic Lateral Sclerosis/drug therapy, Biomedical Research, Disease Progression",
author = "Ustyantseva, {E. I.} and Medvedev, {S. P.} and Zakian, {S. M.}",
note = "Publisher Copyright: {\textcopyright} 2020, Springer Nature Switzerland AG.",
year = "2020",
month = may,
day = "8",
doi = "10.1007/978-3-030-41283-8_11",
language = "English",
isbn = "978-3-030-41282-1",
volume = "1241",
series = "Advances in experimental medicine and biology",
publisher = "Springer, Cham",
pages = "195--217",
editor = "Zharkov, {Dmitry O.}",
booktitle = "Mechanisms of Genome Protection and Repair",

}

RIS

TY - CHAP

T1 - Studying ALS: Current Approaches, Effect on Potential Treatment Strategy

AU - Ustyantseva, E. I.

AU - Medvedev, S. P.

AU - Zakian, S. M.

N1 - Publisher Copyright: © 2020, Springer Nature Switzerland AG.

PY - 2020/5/8

Y1 - 2020/5/8

N2 - Amyotrophic lateral sclerosis (ALS) is one of the most common neurodegenerative diseases, characterized by inevitable progressive paralysis. To date, only two disease modifying therapeutic options are available for the patients with ALS, although they show very modest effect on disease course. The main reason of failure in the field of pharmacological correction of ALS is inability to untangle complex relationships taking place during ALS initiation and progression. Traditional methods of research, based on morphology or transgenic animal models studying provided lots of information about ALS throughout the years. However, translation of these results to humans was unsuccessful due to incomplete recapitulation of molecular pathology and overall inadequacy of the models used in the research.In this review we summarize current knowledge regarding ALS molecular pathology with depiction of novel methods applied recently for the studies. Furthermore we describe present and potential treatment strategies that are based on the recent findings in ALS disease mechanisms.

AB - Amyotrophic lateral sclerosis (ALS) is one of the most common neurodegenerative diseases, characterized by inevitable progressive paralysis. To date, only two disease modifying therapeutic options are available for the patients with ALS, although they show very modest effect on disease course. The main reason of failure in the field of pharmacological correction of ALS is inability to untangle complex relationships taking place during ALS initiation and progression. Traditional methods of research, based on morphology or transgenic animal models studying provided lots of information about ALS throughout the years. However, translation of these results to humans was unsuccessful due to incomplete recapitulation of molecular pathology and overall inadequacy of the models used in the research.In this review we summarize current knowledge regarding ALS molecular pathology with depiction of novel methods applied recently for the studies. Furthermore we describe present and potential treatment strategies that are based on the recent findings in ALS disease mechanisms.

KW - ALS

KW - Amyotrophic lateral sclerosis

KW - Disease mechanisms

KW - Animals

KW - Humans

KW - Amyotrophic Lateral Sclerosis/drug therapy

KW - Biomedical Research

KW - Disease Progression

UR - http://www.scopus.com/inward/record.url?scp=85084389852&partnerID=8YFLogxK

U2 - 10.1007/978-3-030-41283-8_11

DO - 10.1007/978-3-030-41283-8_11

M3 - Chapter

C2 - 32383122

AN - SCOPUS:85084389852

SN - 978-3-030-41282-1

SN - 978-3-030-41285-2

VL - 1241

T3 - Advances in experimental medicine and biology

SP - 195

EP - 217

BT - Mechanisms of Genome Protection and Repair

A2 - Zharkov, Dmitry O.

PB - Springer, Cham

ER -

ID: 28575306