Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › глава/раздел › научная › Рецензирование
Studying ALS: Current Approaches, Effect on Potential Treatment Strategy. / Ustyantseva, E. I.; Medvedev, S. P.; Zakian, S. M.
Mechanisms of Genome Protection and Repair. ред. / Dmitry O. Zharkov. Том 1241 Springer, Cham, 2020. стр. 195-217 (Advances in experimental medicine and biology).Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › глава/раздел › научная › Рецензирование
}
TY - CHAP
T1 - Studying ALS: Current Approaches, Effect on Potential Treatment Strategy
AU - Ustyantseva, E. I.
AU - Medvedev, S. P.
AU - Zakian, S. M.
N1 - Publisher Copyright: © 2020, Springer Nature Switzerland AG.
PY - 2020/5/8
Y1 - 2020/5/8
N2 - Amyotrophic lateral sclerosis (ALS) is one of the most common neurodegenerative diseases, characterized by inevitable progressive paralysis. To date, only two disease modifying therapeutic options are available for the patients with ALS, although they show very modest effect on disease course. The main reason of failure in the field of pharmacological correction of ALS is inability to untangle complex relationships taking place during ALS initiation and progression. Traditional methods of research, based on morphology or transgenic animal models studying provided lots of information about ALS throughout the years. However, translation of these results to humans was unsuccessful due to incomplete recapitulation of molecular pathology and overall inadequacy of the models used in the research.In this review we summarize current knowledge regarding ALS molecular pathology with depiction of novel methods applied recently for the studies. Furthermore we describe present and potential treatment strategies that are based on the recent findings in ALS disease mechanisms.
AB - Amyotrophic lateral sclerosis (ALS) is one of the most common neurodegenerative diseases, characterized by inevitable progressive paralysis. To date, only two disease modifying therapeutic options are available for the patients with ALS, although they show very modest effect on disease course. The main reason of failure in the field of pharmacological correction of ALS is inability to untangle complex relationships taking place during ALS initiation and progression. Traditional methods of research, based on morphology or transgenic animal models studying provided lots of information about ALS throughout the years. However, translation of these results to humans was unsuccessful due to incomplete recapitulation of molecular pathology and overall inadequacy of the models used in the research.In this review we summarize current knowledge regarding ALS molecular pathology with depiction of novel methods applied recently for the studies. Furthermore we describe present and potential treatment strategies that are based on the recent findings in ALS disease mechanisms.
KW - ALS
KW - Amyotrophic lateral sclerosis
KW - Disease mechanisms
KW - Animals
KW - Humans
KW - Amyotrophic Lateral Sclerosis/drug therapy
KW - Biomedical Research
KW - Disease Progression
UR - http://www.scopus.com/inward/record.url?scp=85084389852&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-41283-8_11
DO - 10.1007/978-3-030-41283-8_11
M3 - Chapter
C2 - 32383122
AN - SCOPUS:85084389852
SN - 978-3-030-41282-1
SN - 978-3-030-41285-2
VL - 1241
T3 - Advances in experimental medicine and biology
SP - 195
EP - 217
BT - Mechanisms of Genome Protection and Repair
A2 - Zharkov, Dmitry O.
PB - Springer, Cham
ER -
ID: 28575306