Research output: Contribution to journal › Review article › peer-review
Noncoding RNAs in the Regulation of Pluripotency and Reprogramming. / Sherstyuk, Vladimir V.; Medvedev, Sergey P.; Zakian, Suren M.
In: Stem Cell Reviews and Reports, Vol. 14, No. 1, 01.02.2018, p. 58-70.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Noncoding RNAs in the Regulation of Pluripotency and Reprogramming
AU - Sherstyuk, Vladimir V.
AU - Medvedev, Sergey P.
AU - Zakian, Suren M.
N1 - Publisher Copyright: © 2017, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Pluripotent stem cells have great potential for developmental biology and regenerative medicine. Embryonic stem cells, which are obtained from blastocysts, and induced pluripotent stem cells, which are generated by the reprogramming of somatic cells, are two main types of pluripotent cells. It is important to understand the regulatory network that controls the pluripotency state and reprogramming process. Various types of noncoding RNAs (ncRNAs) have emerged as substantial components of regulatory networks. The most studied class of ncRNAs in the context of pluripotency and reprogramming is microRNAs (miRNAs). In addition to canonical microRNAs, other types of small RNAs with miRNA-like function are expressed in PSCs. Another class of ncRNAs, long ncRNAs, are also involved in pluripotency and reprogramming regulation. Thousands of ncRNAs have been annotated to date, and a significant number of the molecules do not have known function. In this review, we briefly summarized recent advances in this field and described existing genome-editing approaches to study ncRNA functions.
AB - Pluripotent stem cells have great potential for developmental biology and regenerative medicine. Embryonic stem cells, which are obtained from blastocysts, and induced pluripotent stem cells, which are generated by the reprogramming of somatic cells, are two main types of pluripotent cells. It is important to understand the regulatory network that controls the pluripotency state and reprogramming process. Various types of noncoding RNAs (ncRNAs) have emerged as substantial components of regulatory networks. The most studied class of ncRNAs in the context of pluripotency and reprogramming is microRNAs (miRNAs). In addition to canonical microRNAs, other types of small RNAs with miRNA-like function are expressed in PSCs. Another class of ncRNAs, long ncRNAs, are also involved in pluripotency and reprogramming regulation. Thousands of ncRNAs have been annotated to date, and a significant number of the molecules do not have known function. In this review, we briefly summarized recent advances in this field and described existing genome-editing approaches to study ncRNA functions.
KW - CRISPR/Cas9
KW - Genome editing
KW - Long noncoding RNA
KW - MicroRNA
KW - Noncoding RNA
KW - Pluripotency
KW - Pluripotent stem cells
KW - Reprogramming
KW - GROUND-STATE
KW - WIDE IDENTIFICATION
KW - DNA METHYLATION
KW - MESENCHYMAL TRANSITION
KW - MIR-200 FAMILY
KW - SMALL NUCLEOLAR RNA
KW - TRANSCRIPTIONAL REPRESSORS
KW - MIRNA EXPRESSION
KW - EMBRYONIC STEM-CELLS
KW - PROFILING REVEALS
UR - http://www.scopus.com/inward/record.url?scp=85034025880&partnerID=8YFLogxK
U2 - 10.1007/s12015-017-9782-9
DO - 10.1007/s12015-017-9782-9
M3 - Review article
C2 - 29143182
AN - SCOPUS:85034025880
VL - 14
SP - 58
EP - 70
JO - Stem Cell Reviews and Reports
JF - Stem Cell Reviews and Reports
SN - 2629-3269
IS - 1
ER -
ID: 8798081