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Microwave-assisted synthesis and antitumor activity of the supramolecular complexes of betulin diacetate with arabinogalactan. / Malyar, Yuriy N.; Mikhailenko, Mikhail A.; Pankrushina, Natalia A. et al.

In: Chemical Papers, Vol. 72, No. 5, 05.2018, p. 1257-1263.

Research output: Contribution to journal › Article › peer-review

Harvard

Malyar, YN, Mikhailenko, MA, Pankrushina, NA, Mikheev, AN, Eltsov, IV, Kuznetsova, SA, Kichkailo, AS & Shakhtshneider, TP 2018, 'Microwave-assisted synthesis and antitumor activity of the supramolecular complexes of betulin diacetate with arabinogalactan', Chemical Papers, vol. 72, no. 5, pp. 1257-1263. https://doi.org/10.1007/s11696-017-0362-x

APA

Malyar, Y. N., Mikhailenko, M. A., Pankrushina, N. A., Mikheev, A. N., Eltsov, I. V., Kuznetsova, S. A., Kichkailo, A. S., & Shakhtshneider, T. P. (2018). Microwave-assisted synthesis and antitumor activity of the supramolecular complexes of betulin diacetate with arabinogalactan. Chemical Papers, 72(5), 1257-1263. https://doi.org/10.1007/s11696-017-0362-x

Vancouver

Malyar YN, Mikhailenko MA, Pankrushina NA, Mikheev AN, Eltsov IV, Kuznetsova SA et al. Microwave-assisted synthesis and antitumor activity of the supramolecular complexes of betulin diacetate with arabinogalactan. Chemical Papers. 2018 May;72(5):1257-1263. doi: 10.1007/s11696-017-0362-x

Author

Malyar, Yuriy N. ; Mikhailenko, Mikhail A. ; Pankrushina, Natalia A. et al. / Microwave-assisted synthesis and antitumor activity of the supramolecular complexes of betulin diacetate with arabinogalactan. In: Chemical Papers. 2018 ; Vol. 72, No. 5. pp. 1257-1263.

BibTeX

@article{f512386cf79b41679d767480fa49ce32,
title = "Microwave-assisted synthesis and antitumor activity of the supramolecular complexes of betulin diacetate with arabinogalactan",
abstract = "In this work, a water-soluble supramolecular complex was synthesized in an aqueous suspension of betulin diacetate (BDA) and arabinogalactan (AG) upon microwave heating. Microwave heating allows reducing the time required for the complex formation, compared with conventional heating in a water bath. The specific effect of microwave irradiation on the initial reagents and preparation of a supramolecular complex was studied. In contrast to conventional heating, under microwave heating AG macromolecules may break into roughly equal fragments when the temperature increases up to 100 °C. A change in the surface morphology of BDA crystals under microwave heating of the suspension suggests that microwave irradiation facilitates the dissolution of BDA in water. It has been shown that the use of dimethylsulfoxide as a reaction medium for microwave heating led to a decrease in BDA content in the product due to the inclusion of DMSO into AG macromolecules. The BDA–AG complex was isolated from the microwave-heated aqueous solution, after water evaporation, as a thin amorphous film, which exhibited antitumor activity against Ehrlich ascites carcinoma cells and can be a promising material for pharmacological applications.",
keywords = "Betulin diacetate, Arabinogalactan, Complexes, Microwave synthesis, Films, Antitumor activity, DISSOLUTION",
author = "Malyar, {Yuriy N.} and Mikhailenko, {Mikhail A.} and Pankrushina, {Natalia A.} and Mikheev, {Alexander N.} and Eltsov, {Ilia V.} and Kuznetsova, {Svetlana A.} and Kichkailo, {Anna S.} and Shakhtshneider, {Tatyana P.}",
year = "2018",
month = may,
doi = "10.1007/s11696-017-0362-x",
language = "English",
volume = "72",
pages = "1257--1263",
journal = "Chemical Papers",
issn = "0366-6352",
publisher = "Springer International Publishing AG",
number = "5",

}

RIS

TY - JOUR

T1 - Microwave-assisted synthesis and antitumor activity of the supramolecular complexes of betulin diacetate with arabinogalactan

AU - Malyar, Yuriy N.

AU - Mikhailenko, Mikhail A.

AU - Pankrushina, Natalia A.

AU - Mikheev, Alexander N.

AU - Eltsov, Ilia V.

AU - Kuznetsova, Svetlana A.

AU - Kichkailo, Anna S.

AU - Shakhtshneider, Tatyana P.

PY - 2018/5

Y1 - 2018/5

N2 - In this work, a water-soluble supramolecular complex was synthesized in an aqueous suspension of betulin diacetate (BDA) and arabinogalactan (AG) upon microwave heating. Microwave heating allows reducing the time required for the complex formation, compared with conventional heating in a water bath. The specific effect of microwave irradiation on the initial reagents and preparation of a supramolecular complex was studied. In contrast to conventional heating, under microwave heating AG macromolecules may break into roughly equal fragments when the temperature increases up to 100 °C. A change in the surface morphology of BDA crystals under microwave heating of the suspension suggests that microwave irradiation facilitates the dissolution of BDA in water. It has been shown that the use of dimethylsulfoxide as a reaction medium for microwave heating led to a decrease in BDA content in the product due to the inclusion of DMSO into AG macromolecules. The BDA–AG complex was isolated from the microwave-heated aqueous solution, after water evaporation, as a thin amorphous film, which exhibited antitumor activity against Ehrlich ascites carcinoma cells and can be a promising material for pharmacological applications.

AB - In this work, a water-soluble supramolecular complex was synthesized in an aqueous suspension of betulin diacetate (BDA) and arabinogalactan (AG) upon microwave heating. Microwave heating allows reducing the time required for the complex formation, compared with conventional heating in a water bath. The specific effect of microwave irradiation on the initial reagents and preparation of a supramolecular complex was studied. In contrast to conventional heating, under microwave heating AG macromolecules may break into roughly equal fragments when the temperature increases up to 100 °C. A change in the surface morphology of BDA crystals under microwave heating of the suspension suggests that microwave irradiation facilitates the dissolution of BDA in water. It has been shown that the use of dimethylsulfoxide as a reaction medium for microwave heating led to a decrease in BDA content in the product due to the inclusion of DMSO into AG macromolecules. The BDA–AG complex was isolated from the microwave-heated aqueous solution, after water evaporation, as a thin amorphous film, which exhibited antitumor activity against Ehrlich ascites carcinoma cells and can be a promising material for pharmacological applications.

KW - Betulin diacetate

KW - Arabinogalactan

KW - Complexes

KW - Microwave synthesis

KW - Films

KW - Antitumor activity

KW - DISSOLUTION

UR - http://www.scopus.com/inward/record.url?scp=85060347961&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/69e57a97-f99f-3cfa-b4cd-ae08d9bad0df/

U2 - 10.1007/s11696-017-0362-x

DO - 10.1007/s11696-017-0362-x

M3 - Article

VL - 72

SP - 1257

EP - 1263

JO - Chemical Papers

JF - Chemical Papers

SN - 0366-6352

IS - 5

ER -

ID: 18698881