Standard

A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases. / Zaitseva, Olga O.; Sharapov, Sodbo Z.; Klaric, Lucija et al.

In: Glycobiology, Vol. 30, No. 12, 12.2020, p. 1132-1132.

Research output: Contribution to journal › Meeting Abstract › peer-review

Harvard

Zaitseva, OO, Sharapov, SZ, Klaric, L, Lauc, G & Tsepilov, YA 2020, 'A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases', Glycobiology, vol. 30, no. 12, pp. 1132-1132.

APA

Zaitseva, O. O., Sharapov, S. Z., Klaric, L., Lauc, G., & Tsepilov, Y. A. (2020). A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases. Glycobiology, 30(12), 1132-1132.

Vancouver

Zaitseva OO, Sharapov SZ, Klaric L, Lauc G, Tsepilov YA. A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases. Glycobiology. 2020 Dec;30(12):1132-1132.

Author

Zaitseva, Olga O. ; Sharapov, Sodbo Z. ; Klaric, Lucija et al. / A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases. In: Glycobiology. 2020 ; Vol. 30, No. 12. pp. 1132-1132.

BibTeX

@article{373cffbf3cfd4ca9af771bd9e81c48f5,
title = "A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases",
abstract = "N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.",
author = "Zaitseva, {Olga O.} and Sharapov, {Sodbo Z.} and Lucija Klaric and Gordan Lauc and Tsepilov, {Yakov A.}",
year = "2020",
month = dec,
language = "English",
volume = "30",
pages = "1132--1132",
journal = "Glycobiology",
issn = "0959-6658",
publisher = "Oxford University Press",
number = "12",

}

RIS

TY - JOUR

T1 - A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases

AU - Zaitseva, Olga O.

AU - Sharapov, Sodbo Z.

AU - Klaric, Lucija

AU - Lauc, Gordan

AU - Tsepilov, Yakov A.

PY - 2020/12

Y1 - 2020/12

N2 - N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.

AB - N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.

M3 - Meeting Abstract

VL - 30

SP - 1132

EP - 1132

JO - Glycobiology

JF - Glycobiology

SN - 0959-6658

IS - 12

ER -

ID: 27653080