TY - JOUR

T1 - A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases

AU - Zaitseva, Olga O.

AU - Sharapov, Sodbo Z.

AU - Klaric, Lucija

AU - Lauc, Gordan

AU - Tsepilov, Yakov A.

PY - 2020/12

Y1 - 2020/12

N2 - N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.

AB - N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.

M3 - Meeting Abstract

VL - 30

SP - 1132

EP - 1132

JO - Glycobiology

JF - Glycobiology

SN - 0959-6658

IS - 12

ER -