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A Sacrifice-for-Survival Mechanism Protects Root Stem Cell Niche from Chilling Stress. / Hong, Jing Han; Savina, Maria; Du, Jing et al.

In: Cell, Vol. 170, No. 1, 29.06.2017, p. 102-113.e14.

Research output: Contribution to journal › Article › peer-review

Harvard

Hong, JH, Savina, M, Du, J, Devendran, A, Kannivadi Ramakanth, K, Tian, X, Sim, WS, Mironova, VV & Xu, J 2017, 'A Sacrifice-for-Survival Mechanism Protects Root Stem Cell Niche from Chilling Stress', Cell, vol. 170, no. 1, pp. 102-113.e14. https://doi.org/10.1016/j.cell.2017.06.002

APA

Hong, J. H., Savina, M., Du, J., Devendran, A., Kannivadi Ramakanth, K., Tian, X., Sim, W. S., Mironova, V. V., & Xu, J. (2017). A Sacrifice-for-Survival Mechanism Protects Root Stem Cell Niche from Chilling Stress. Cell, 170(1), 102-113.e14. https://doi.org/10.1016/j.cell.2017.06.002

Vancouver

Hong JH, Savina M, Du J, Devendran A, Kannivadi Ramakanth K, Tian X et al. A Sacrifice-for-Survival Mechanism Protects Root Stem Cell Niche from Chilling Stress. Cell. 2017 Jun 29;170(1):102-113.e14. doi: 10.1016/j.cell.2017.06.002

Author

Hong, Jing Han ; Savina, Maria ; Du, Jing et al. / A Sacrifice-for-Survival Mechanism Protects Root Stem Cell Niche from Chilling Stress. In: Cell. 2017 ; Vol. 170, No. 1. pp. 102-113.e14.

BibTeX

@article{f34da53bd32c4a4f80035297cde49a2c,
title = "A Sacrifice-for-Survival Mechanism Protects Root Stem Cell Niche from Chilling Stress",
abstract = "Temperature has a profound influence on plant and animal development, but its effects on stem cell behavior and activity remain poorly understood. Here, we characterize the responses of the Arabidopsis root to chilling (low but above-freezing) temperature. Chilling stress at 4°C leads to DNA damage predominantly in root stem cells and their early descendants. However, only newly generated/differentiating columella stem cell daughters (CSCDs) preferentially die in a programmed manner. Inhibition of the DNA damage response in these CSCDs prevents their death but makes the stem cell niche more vulnerable to chilling stress. Mathematical modeling and experimental validation indicate that CSCD death results in the re-establishment of the auxin maximum in the quiescent center (QC) and the maintenance of functional stem cell niche activity under chilling stress. This mechanism improves the root's ability to withstand the accompanying environmental stresses and to resume growth when optimal temperatures are restored.",
keywords = "auxin maximum, chilling stress, DNA damage, selective cell death, stem cell survival, Cold Temperature, Stem Cell Niche, Stress, Physiological, Plant Roots/cytology, Indoleacetic Acids/metabolism, Cell Division, Arabidopsis/physiology, Stem Cells/cytology, ARABIDOPSIS-THALIANA, DNA-DAMAGE, AGROBACTERIUM-MEDIATED TRANSFORMATION, FLORAL DIP, PIN, PLANT COLD-ACCLIMATION, GROWTH, DIFFERENTIATION, AUXIN HOMEOSTASIS, FREEZING TOLERANCE",
author = "Hong, {Jing Han} and Maria Savina and Jing Du and Ajay Devendran and {Kannivadi Ramakanth}, Karthikbabu and Xin Tian and Sim, {Wei Shi} and Mironova, {Victoria V.} and Jian Xu",
note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",
year = "2017",
month = jun,
day = "29",
doi = "10.1016/j.cell.2017.06.002",
language = "English",
volume = "170",
pages = "102--113.e14",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - A Sacrifice-for-Survival Mechanism Protects Root Stem Cell Niche from Chilling Stress

AU - Hong, Jing Han

AU - Savina, Maria

AU - Du, Jing

AU - Devendran, Ajay

AU - Kannivadi Ramakanth, Karthikbabu

AU - Tian, Xin

AU - Sim, Wei Shi

AU - Mironova, Victoria V.

AU - Xu, Jian

N1 - Publisher Copyright: © 2017 Elsevier Inc.

PY - 2017/6/29

Y1 - 2017/6/29

N2 - Temperature has a profound influence on plant and animal development, but its effects on stem cell behavior and activity remain poorly understood. Here, we characterize the responses of the Arabidopsis root to chilling (low but above-freezing) temperature. Chilling stress at 4°C leads to DNA damage predominantly in root stem cells and their early descendants. However, only newly generated/differentiating columella stem cell daughters (CSCDs) preferentially die in a programmed manner. Inhibition of the DNA damage response in these CSCDs prevents their death but makes the stem cell niche more vulnerable to chilling stress. Mathematical modeling and experimental validation indicate that CSCD death results in the re-establishment of the auxin maximum in the quiescent center (QC) and the maintenance of functional stem cell niche activity under chilling stress. This mechanism improves the root's ability to withstand the accompanying environmental stresses and to resume growth when optimal temperatures are restored.

AB - Temperature has a profound influence on plant and animal development, but its effects on stem cell behavior and activity remain poorly understood. Here, we characterize the responses of the Arabidopsis root to chilling (low but above-freezing) temperature. Chilling stress at 4°C leads to DNA damage predominantly in root stem cells and their early descendants. However, only newly generated/differentiating columella stem cell daughters (CSCDs) preferentially die in a programmed manner. Inhibition of the DNA damage response in these CSCDs prevents their death but makes the stem cell niche more vulnerable to chilling stress. Mathematical modeling and experimental validation indicate that CSCD death results in the re-establishment of the auxin maximum in the quiescent center (QC) and the maintenance of functional stem cell niche activity under chilling stress. This mechanism improves the root's ability to withstand the accompanying environmental stresses and to resume growth when optimal temperatures are restored.

KW - auxin maximum

KW - chilling stress

KW - DNA damage

KW - selective cell death

KW - stem cell survival

KW - Cold Temperature

KW - Stem Cell Niche

KW - Stress, Physiological

KW - Plant Roots/cytology

KW - Indoleacetic Acids/metabolism

KW - Cell Division

KW - Arabidopsis/physiology

KW - Stem Cells/cytology

KW - ARABIDOPSIS-THALIANA

KW - DNA-DAMAGE

KW - AGROBACTERIUM-MEDIATED TRANSFORMATION

KW - FLORAL DIP

KW - PIN

KW - PLANT COLD-ACCLIMATION

KW - GROWTH

KW - DIFFERENTIATION

KW - AUXIN HOMEOSTASIS

KW - FREEZING TOLERANCE

UR - http://www.scopus.com/inward/record.url?scp=85021114218&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2017.06.002

DO - 10.1016/j.cell.2017.06.002

M3 - Article

C2 - 28648662

AN - SCOPUS:85021114218

VL - 170

SP - 102-113.e14

JO - Cell

JF - Cell

SN - 0092-8674

IS - 1

ER -

ID: 10183815