Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
A Sacrifice-for-Survival Mechanism Protects Root Stem Cell Niche from Chilling Stress. / Hong, Jing Han; Savina, Maria; Du, Jing и др.
в: Cell, Том 170, № 1, 29.06.2017, стр. 102-113.e14.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - A Sacrifice-for-Survival Mechanism Protects Root Stem Cell Niche from Chilling Stress
AU - Hong, Jing Han
AU - Savina, Maria
AU - Du, Jing
AU - Devendran, Ajay
AU - Kannivadi Ramakanth, Karthikbabu
AU - Tian, Xin
AU - Sim, Wei Shi
AU - Mironova, Victoria V.
AU - Xu, Jian
N1 - Publisher Copyright: © 2017 Elsevier Inc.
PY - 2017/6/29
Y1 - 2017/6/29
N2 - Temperature has a profound influence on plant and animal development, but its effects on stem cell behavior and activity remain poorly understood. Here, we characterize the responses of the Arabidopsis root to chilling (low but above-freezing) temperature. Chilling stress at 4°C leads to DNA damage predominantly in root stem cells and their early descendants. However, only newly generated/differentiating columella stem cell daughters (CSCDs) preferentially die in a programmed manner. Inhibition of the DNA damage response in these CSCDs prevents their death but makes the stem cell niche more vulnerable to chilling stress. Mathematical modeling and experimental validation indicate that CSCD death results in the re-establishment of the auxin maximum in the quiescent center (QC) and the maintenance of functional stem cell niche activity under chilling stress. This mechanism improves the root's ability to withstand the accompanying environmental stresses and to resume growth when optimal temperatures are restored.
AB - Temperature has a profound influence on plant and animal development, but its effects on stem cell behavior and activity remain poorly understood. Here, we characterize the responses of the Arabidopsis root to chilling (low but above-freezing) temperature. Chilling stress at 4°C leads to DNA damage predominantly in root stem cells and their early descendants. However, only newly generated/differentiating columella stem cell daughters (CSCDs) preferentially die in a programmed manner. Inhibition of the DNA damage response in these CSCDs prevents their death but makes the stem cell niche more vulnerable to chilling stress. Mathematical modeling and experimental validation indicate that CSCD death results in the re-establishment of the auxin maximum in the quiescent center (QC) and the maintenance of functional stem cell niche activity under chilling stress. This mechanism improves the root's ability to withstand the accompanying environmental stresses and to resume growth when optimal temperatures are restored.
KW - auxin maximum
KW - chilling stress
KW - DNA damage
KW - selective cell death
KW - stem cell survival
KW - Cold Temperature
KW - Stem Cell Niche
KW - Stress, Physiological
KW - Plant Roots/cytology
KW - Indoleacetic Acids/metabolism
KW - Cell Division
KW - Arabidopsis/physiology
KW - Stem Cells/cytology
KW - ARABIDOPSIS-THALIANA
KW - DNA-DAMAGE
KW - AGROBACTERIUM-MEDIATED TRANSFORMATION
KW - FLORAL DIP
KW - PIN
KW - PLANT COLD-ACCLIMATION
KW - GROWTH
KW - DIFFERENTIATION
KW - AUXIN HOMEOSTASIS
KW - FREEZING TOLERANCE
UR - http://www.scopus.com/inward/record.url?scp=85021114218&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2017.06.002
DO - 10.1016/j.cell.2017.06.002
M3 - Article
C2 - 28648662
AN - SCOPUS:85021114218
VL - 170
SP - 102-113.e14
JO - Cell
JF - Cell
SN - 0092-8674
IS - 1
ER -
ID: 10183815