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A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity. / Krasilnikova, Anna A.; Solovieva, Anastasiya O.; Ivanov, Anton A. et al.

In: Toxicology Research, Vol. 6, No. 4, 01.07.2017, p. 554-560.

Research output: Contribution to journal › Article › peer-review

Harvard

Krasilnikova, AA, Solovieva, AO, Ivanov, AA, Brylev, KA, Pozmogova, TN, Gulyaeva, MA, Kurskaya, OG, Alekseev, AY, Shestopalov, AM, Shestopalova, LV, Poveshchenko, AF, Efremova, OA, Mironov, YV & Shestopalov, MA 2017, 'A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity', Toxicology Research, vol. 6, no. 4, pp. 554-560. https://doi.org/10.1039/c7tx00083a

APA

Krasilnikova, A. A., Solovieva, A. O., Ivanov, A. A., Brylev, K. A., Pozmogova, T. N., Gulyaeva, M. A., Kurskaya, O. G., Alekseev, A. Y., Shestopalov, A. M., Shestopalova, L. V., Poveshchenko, A. F., Efremova, O. A., Mironov, Y. V., & Shestopalov, M. A. (2017). A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity. Toxicology Research, 6(4), 554-560. https://doi.org/10.1039/c7tx00083a

Vancouver

Krasilnikova AA, Solovieva AO, Ivanov AA, Brylev KA, Pozmogova TN, Gulyaeva MA et al. A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity. Toxicology Research. 2017 Jul 1;6(4):554-560. doi: 10.1039/c7tx00083a

Author

Krasilnikova, Anna A. ; Solovieva, Anastasiya O. ; Ivanov, Anton A. et al. / A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity. In: Toxicology Research. 2017 ; Vol. 6, No. 4. pp. 554-560.

BibTeX

@article{0ff0b6b63fef467cb3a482921cf62e98,
title = "A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity",
abstract = "The octahedral rhenium cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] has recently emerged as a very promising X-ray contrast agent for biomedical applications. However, the synthesis of this compound is rather challenging due to the difficulty in controlling the hydrolysis of the initial P(C2H4CN)3 ligand during the reaction process. Therefore, in this report we compare the in vitro and in vivo toxicity of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] with those of related compounds featuring the fully hydrolysed form of the phosphine ligand, namely Na2H14[{Re6Q8}(P(C2H4COO)3)6] (Q = S or Se). Our results demonstrate that the cytotoxicity and acute in vivo toxicity of the complex Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] solutions were considerably lower than those of compounds with the fully hydrolysed ligand P(C2H4COOH)3. Such behavior can be explained by the higher osmolality of Na2H14[{Re6Q8}(P(C2H4COO)3)6] versus Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6].",
keywords = "CELLS, CELLULAR INTERNALIZATION, CHRONIC INFLAMMATION, CYTOTOXICITY, DISEASES, ENCAPSULATION, GOLD NANOPARTICLES, LUMINESCENCE, RAY CONTRAST AGENT, SILICA NANOPARTICLES",
author = "Krasilnikova, {Anna A.} and Solovieva, {Anastasiya O.} and Ivanov, {Anton A.} and Brylev, {Konstantin A.} and Pozmogova, {Tatiana N.} and Gulyaeva, {Marina A.} and Kurskaya, {Olga G.} and Alekseev, {Alexander Y.} and Shestopalov, {Alexander M.} and Shestopalova, {Lidiya V.} and Poveshchenko, {Alexander F.} and Efremova, {Olga A.} and Mironov, {Yuri V.} and Shestopalov, {Michael A.}",
note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2017.",
year = "2017",
month = jul,
day = "1",
doi = "10.1039/c7tx00083a",
language = "English",
volume = "6",
pages = "554--560",
journal = "Toxicology Research",
issn = "2045-452X",
publisher = "Royal Society of Chemistry",
number = "4",

}

RIS

TY - JOUR

T1 - A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity

AU - Krasilnikova, Anna A.

AU - Solovieva, Anastasiya O.

AU - Ivanov, Anton A.

AU - Brylev, Konstantin A.

AU - Pozmogova, Tatiana N.

AU - Gulyaeva, Marina A.

AU - Kurskaya, Olga G.

AU - Alekseev, Alexander Y.

AU - Shestopalov, Alexander M.

AU - Shestopalova, Lidiya V.

AU - Poveshchenko, Alexander F.

AU - Efremova, Olga A.

AU - Mironov, Yuri V.

AU - Shestopalov, Michael A.

N1 - Publisher Copyright: © The Royal Society of Chemistry 2017.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - The octahedral rhenium cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] has recently emerged as a very promising X-ray contrast agent for biomedical applications. However, the synthesis of this compound is rather challenging due to the difficulty in controlling the hydrolysis of the initial P(C2H4CN)3 ligand during the reaction process. Therefore, in this report we compare the in vitro and in vivo toxicity of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] with those of related compounds featuring the fully hydrolysed form of the phosphine ligand, namely Na2H14[{Re6Q8}(P(C2H4COO)3)6] (Q = S or Se). Our results demonstrate that the cytotoxicity and acute in vivo toxicity of the complex Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] solutions were considerably lower than those of compounds with the fully hydrolysed ligand P(C2H4COOH)3. Such behavior can be explained by the higher osmolality of Na2H14[{Re6Q8}(P(C2H4COO)3)6] versus Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6].

AB - The octahedral rhenium cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] has recently emerged as a very promising X-ray contrast agent for biomedical applications. However, the synthesis of this compound is rather challenging due to the difficulty in controlling the hydrolysis of the initial P(C2H4CN)3 ligand during the reaction process. Therefore, in this report we compare the in vitro and in vivo toxicity of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] with those of related compounds featuring the fully hydrolysed form of the phosphine ligand, namely Na2H14[{Re6Q8}(P(C2H4COO)3)6] (Q = S or Se). Our results demonstrate that the cytotoxicity and acute in vivo toxicity of the complex Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] solutions were considerably lower than those of compounds with the fully hydrolysed ligand P(C2H4COOH)3. Such behavior can be explained by the higher osmolality of Na2H14[{Re6Q8}(P(C2H4COO)3)6] versus Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6].

KW - CELLS

KW - CELLULAR INTERNALIZATION

KW - CHRONIC INFLAMMATION

KW - CYTOTOXICITY

KW - DISEASES

KW - ENCAPSULATION

KW - GOLD NANOPARTICLES

KW - LUMINESCENCE

KW - RAY CONTRAST AGENT

KW - SILICA NANOPARTICLES

UR - http://www.scopus.com/inward/record.url?scp=85021715820&partnerID=8YFLogxK

U2 - 10.1039/c7tx00083a

DO - 10.1039/c7tx00083a

M3 - Article

C2 - 30090524

AN - SCOPUS:85021715820

VL - 6

SP - 554

EP - 560

JO - Toxicology Research

JF - Toxicology Research

SN - 2045-452X

IS - 4

ER -

ID: 9029699