Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity. / Krasilnikova, Anna A.; Solovieva, Anastasiya O.; Ivanov, Anton A. и др.
в: Toxicology Research, Том 6, № 4, 01.07.2017, стр. 554-560.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity
AU - Krasilnikova, Anna A.
AU - Solovieva, Anastasiya O.
AU - Ivanov, Anton A.
AU - Brylev, Konstantin A.
AU - Pozmogova, Tatiana N.
AU - Gulyaeva, Marina A.
AU - Kurskaya, Olga G.
AU - Alekseev, Alexander Y.
AU - Shestopalov, Alexander M.
AU - Shestopalova, Lidiya V.
AU - Poveshchenko, Alexander F.
AU - Efremova, Olga A.
AU - Mironov, Yuri V.
AU - Shestopalov, Michael A.
N1 - Publisher Copyright: © The Royal Society of Chemistry 2017.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - The octahedral rhenium cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] has recently emerged as a very promising X-ray contrast agent for biomedical applications. However, the synthesis of this compound is rather challenging due to the difficulty in controlling the hydrolysis of the initial P(C2H4CN)3 ligand during the reaction process. Therefore, in this report we compare the in vitro and in vivo toxicity of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] with those of related compounds featuring the fully hydrolysed form of the phosphine ligand, namely Na2H14[{Re6Q8}(P(C2H4COO)3)6] (Q = S or Se). Our results demonstrate that the cytotoxicity and acute in vivo toxicity of the complex Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] solutions were considerably lower than those of compounds with the fully hydrolysed ligand P(C2H4COOH)3. Such behavior can be explained by the higher osmolality of Na2H14[{Re6Q8}(P(C2H4COO)3)6] versus Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6].
AB - The octahedral rhenium cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] has recently emerged as a very promising X-ray contrast agent for biomedical applications. However, the synthesis of this compound is rather challenging due to the difficulty in controlling the hydrolysis of the initial P(C2H4CN)3 ligand during the reaction process. Therefore, in this report we compare the in vitro and in vivo toxicity of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] with those of related compounds featuring the fully hydrolysed form of the phosphine ligand, namely Na2H14[{Re6Q8}(P(C2H4COO)3)6] (Q = S or Se). Our results demonstrate that the cytotoxicity and acute in vivo toxicity of the complex Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] solutions were considerably lower than those of compounds with the fully hydrolysed ligand P(C2H4COOH)3. Such behavior can be explained by the higher osmolality of Na2H14[{Re6Q8}(P(C2H4COO)3)6] versus Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6].
KW - CELLS
KW - CELLULAR INTERNALIZATION
KW - CHRONIC INFLAMMATION
KW - CYTOTOXICITY
KW - DISEASES
KW - ENCAPSULATION
KW - GOLD NANOPARTICLES
KW - LUMINESCENCE
KW - RAY CONTRAST AGENT
KW - SILICA NANOPARTICLES
UR - http://www.scopus.com/inward/record.url?scp=85021715820&partnerID=8YFLogxK
U2 - 10.1039/c7tx00083a
DO - 10.1039/c7tx00083a
M3 - Article
C2 - 30090524
AN - SCOPUS:85021715820
VL - 6
SP - 554
EP - 560
JO - Toxicology Research
JF - Toxicology Research
SN - 2045-452X
IS - 4
ER -
ID: 9029699