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  1. 2020

  2. Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening

    Mamontova, E. M., Zakharenko, A. L., Zakharova, O. D., Dyrkheeva, N. S., Volcho, K. P., Reynisson, J., Arabshahi, H. J., Salakhutdinov, N. F. & Lavrik, O. I., 1 Jan 2020, In: Bioorganic and Medicinal Chemistry. 28, 1, 11 p., 115234.

    Research output: Contribution to journal › Article › peer-review

  3. Promising new inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 4- arylcoumarin and monoterpenoid moieties as components of complex antitumor therapy

    Khomenko, T. M., Zakharenko, A. L., Chepanova, A. A., Ilina, E. S., Zakharova, O. D., Kaledin, V. I., Nikolin, V. P., Popova, N. A., Korchagina, D. V., Reynisson, J., Chand, R., Ayine-tora, D. M., Patel, J., Leung, I. K. H., Volcho, K. P., Salakhutdinov, N. F. & Lavrik, O. I., 1 Jan 2020, In: International Journal of Molecular Sciences. 21, 1, 21 p., 126.

    Research output: Contribution to journal › Article › peer-review

  4. Naked mole rat cells display more efficient DNA excision repair and higher resistance to toxic impacts than mouse cells

    Evdokimov, A., Petruseva, I., Popov, A., Koval, O. & Lavrik, O., 2020, INTERNATIONAL CONFERENCE LONGEVITY INTERVENTIONS 2020 (ICLI 2020). Kovtun, O. & Bazarnyi (eds.). University of Lueneburg, Department of Economics and Social Sciences, Research Institute on Professions, 6 p. 01017. (BIO Web of Conferences; vol. 22).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review

  5. 2019

  6. Effective Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 Based on Monoterpenoids as Potential Agents for Antitumor Therapy

    Chepanova, A. A., Li-Zhulanov, N. S., Sukhikh, A. S., Zafar, A., Reynisson, J., Zakharenko, A. L., Zakharova, O. D., Korchagina, D. V., Volcho, K. P., Salakhutdinov, N. F. & Lavrik, O. I., 1 Nov 2019, In: Russian Journal of Bioorganic Chemistry. 45, 6, p. 647-655 9 p.

    Research output: Contribution to journal › Article › peer-review

  7. New hydrazinothiazole derivatives of usnic acid as potent TDP1 inhibitors

    Filimonov, A. S., Chepanova, A. A., Luzina, O. A., Zakharenko, A. L., Zakharova, O. D., Ilina, E. S., Dyrkheeva, N. S., Kuprushkin, M. S., Kolotaev, A. V., Khachatryan, D. S., Patel, J., Leung, I. K. H., Chand, R., Ayine-Tora, D. M., Reynisson, J., Volcho, K. P., Salakhutdinov, N. F. & Lavrik, O. I., 15 Oct 2019, In: Molecules. 24, 20, 3711.

    Research output: Contribution to journal › Article › peer-review

  8. Double-Stranded DNA Fragments Bearing Unrepairable Lesions and Their Internalization into Mouse Krebs-2 Carcinoma Cells

    Dolgova, E. V., Evdokimov, A. N., Proskurina, A. S., Efremov, Y. R., Bayborodin, S. I., Potter, E. A., Popov, A. A., Petruseva, I. O., Lavrik, O. I. & Bogachev, S. S., 1 Oct 2019, In: Nucleic Acid Therapeutics. 29, 5, p. 278-290 13 p.

    Research output: Contribution to journal › Article › peer-review

  9. Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells

    Kovaleva, K., Oleshko, O., Mamontova, E., Yarovaya, O., Zakharova, O., Zakharenko, A., Kononova, A., Dyrkheeva, N., Cheresiz, S., Pokrovsky, A., Lavrik, O. & Salakhutdinov, N., 27 Sept 2019, In: Journal of Natural Products. 82, 9, p. 2443-2450 8 p.

    Research output: Contribution to journal › Article › peer-review

  10. DNA complexes with human apurinic/apyrimidinic endonuclease 1: structural insights revealed by pulsed dipolar EPR with orthogonal spin labeling

    Krumkacheva, O. A., Shevelev, G. Y., Lomzov, A. A., Dyrkheeva, N. S., Kuzhelev, A. A., Koval, V. V., Tormyshev, V. M., Polienko, Y. F., Fedin, M. V., Pyshnyi, D. V., Lavrik, O. I. & Bagryanskaya, E. G., 5 Sept 2019, In: Nucleic Acids Research. 47, 15, p. 7767-7780 14 p.

    Research output: Contribution to journal › Article › peer-review

  11. Post-translational Modifications of Nucleotide Excision Repair Proteins and Their Role in the DNA Repair

    Rechkunova, N. I., Maltseva, E. A. & Lavrik, O. I., 1 Sept 2019, In: Biochemistry (Moscow). 84, 9, p. 1008-1020 13 p.

    Research output: Contribution to journal › Review article › peer-review

  12. 1-Адамантил-3-(((1R,4aS,10aR)-7-изопропил-1,4а-диметил-1,2,3,4,4а,9,10,10а-октагидрофенантрен-1-ил)метил)мочевина, проявляющая ингибирующее действие в отношении фермента тирозил-ДНК-фосфодиэстеразы 1 человека и увеличивающая активность темозоломида в отношении клеток глиобластомы

    Олешко, О. С., Ковалева, К. С., Яровая, О. И., Мамонтова, Е. М., Захаренко, А. Л., Захарова, О. Д., Чересиз, С. В., Покровский, А. Г., Лаврик, О. И. & Салахутдинов, Н. Ф., 14 Aug 2019, IPC No. C07C275/22, C07C275/24, A61K31/17, A61P35/00, Роспатент - Федеральная служба по интеллектуальной собственности, Patent No. 2697409, Priority date 30 Apr 2019, Priority No. 2019113591

    Research output: Patent › Patent for invention

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