Promising new inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 4- arylcoumarin and monoterpenoid moieties as components of complex antitumor therapy

Original language	English
Article number	126
Number of pages	21
Journal	International Journal of Molecular Sciences
Volume	21
Issue number	1
DOIs	https://doi.org/10.3390/ijms21010126
Publication status	Published - 1 Jan 2020

Cancer, Chemical space, Coumarin, DNA repair enzymes, Molecular modeling, Neoflavone, Tdp1 inhibitor, Topoisomerase 1 inhibitors, Topotecan, Tumor, EMPIRICAL SCORING FUNCTIONS, TOPOISOMERASE-I, BIOLOGICAL EVALUATION, chemical space, topotecan, CONSTITUENTS, coumarin, IDENTIFICATION, ENHANCE, neoflavone, molecular modeling, tumor, PROTEIN-LIGAND DOCKING, topoisomerase 1 inhibitors, RHABDOMYOSARCOMA, IRINOTECAN, cancer, COUMARIN DERIVATIVES

ID: 22997516