Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Water-Soluble Chalcogenide W6-Clusters: On the Way to Biomedical Applications. / Gassan, Alena D.; Ivanov, Anton A.; Pozmogova, Tatiana N. и др.
в: International Journal of Molecular Sciences, Том 23, № 15, 8734, 05.08.2022.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Water-Soluble Chalcogenide W6-Clusters: On the Way to Biomedical Applications
AU - Gassan, Alena D.
AU - Ivanov, Anton A.
AU - Pozmogova, Tatiana N.
AU - Eltsov, Ilia V.
AU - Kuratieva, Natalia V.
AU - Mironov, Yuri V.
AU - Shestopalov, Michael A.
N1 - Publisher Copyright: © 2022 by the authors.
PY - 2022/8/5
Y1 - 2022/8/5
N2 - Despite the great potential of octahedral tungsten cluster complexes in fields of biomedical applications such as X-ray computed tomography or angiography, there is only one example of a water-soluble W6Q8-cluster that has been reported in the literature. Herein we present the synthesis and a detailed characterization including X-ray structural analysis, NMR, IR, UV-Vis spectroscopies, HR-MS spectrometry, and the electrochemical behavior of two new cluster complexes of the general formula W6Q8L6 with phosphine ligands containing a hydrophilic carboxylic group, which makes the complexes soluble in an aqueous medium. The hydrolytic stability of the clusters' aqueous solutions allows us to investigate for the first time the influence of W6-clusters on cell viability. The results obtained clearly demonstrate their very low cytotoxicity, comparable to the least-toxic clusters presented in the literature.
AB - Despite the great potential of octahedral tungsten cluster complexes in fields of biomedical applications such as X-ray computed tomography or angiography, there is only one example of a water-soluble W6Q8-cluster that has been reported in the literature. Herein we present the synthesis and a detailed characterization including X-ray structural analysis, NMR, IR, UV-Vis spectroscopies, HR-MS spectrometry, and the electrochemical behavior of two new cluster complexes of the general formula W6Q8L6 with phosphine ligands containing a hydrophilic carboxylic group, which makes the complexes soluble in an aqueous medium. The hydrolytic stability of the clusters' aqueous solutions allows us to investigate for the first time the influence of W6-clusters on cell viability. The results obtained clearly demonstrate their very low cytotoxicity, comparable to the least-toxic clusters presented in the literature.
KW - crystal structure
KW - cytotoxicity
KW - octahedral chalcogenide tungsten clusters
KW - water solubility
UR - http://www.scopus.com/inward/record.url?scp=85136341705&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/f6bcc89c-cfdb-3482-a59e-e8515ddb08a9/
U2 - 10.3390/ijms23158734
DO - 10.3390/ijms23158734
M3 - Article
C2 - 35955875
AN - SCOPUS:85136341705
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 15
M1 - 8734
ER -
ID: 37000146