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Water-Soluble Chalcogenide W6-Clusters: On the Way to Biomedical Applications. / Gassan, Alena D.; Ivanov, Anton A.; Pozmogova, Tatiana N. et al.

In: International Journal of Molecular Sciences, Vol. 23, No. 15, 8734, 05.08.2022.

Research output: Contribution to journal › Article › peer-review

Harvard

Gassan, AD, Ivanov, AA, Pozmogova, TN, Eltsov, IV, Kuratieva, NV, Mironov, YV & Shestopalov, MA 2022, 'Water-Soluble Chalcogenide W6-Clusters: On the Way to Biomedical Applications', International Journal of Molecular Sciences, vol. 23, no. 15, 8734. https://doi.org/10.3390/ijms23158734

APA

Gassan, A. D., Ivanov, A. A., Pozmogova, T. N., Eltsov, I. V., Kuratieva, N. V., Mironov, Y. V., & Shestopalov, M. A. (2022). Water-Soluble Chalcogenide W6-Clusters: On the Way to Biomedical Applications. International Journal of Molecular Sciences, 23(15), [8734]. https://doi.org/10.3390/ijms23158734

Vancouver

Gassan AD, Ivanov AA, Pozmogova TN, Eltsov IV, Kuratieva NV, Mironov YV et al. Water-Soluble Chalcogenide W6-Clusters: On the Way to Biomedical Applications. International Journal of Molecular Sciences. 2022 Aug 5;23(15):8734. doi: 10.3390/ijms23158734

Author

Gassan, Alena D. ; Ivanov, Anton A. ; Pozmogova, Tatiana N. et al. / Water-Soluble Chalcogenide W6-Clusters: On the Way to Biomedical Applications. In: International Journal of Molecular Sciences. 2022 ; Vol. 23, No. 15.

BibTeX

@article{e78839d4a1464dfebda79190cdc5292d,
title = "Water-Soluble Chalcogenide W6-Clusters: On the Way to Biomedical Applications",
abstract = "Despite the great potential of octahedral tungsten cluster complexes in fields of biomedical applications such as X-ray computed tomography or angiography, there is only one example of a water-soluble W6Q8-cluster that has been reported in the literature. Herein we present the synthesis and a detailed characterization including X-ray structural analysis, NMR, IR, UV-Vis spectroscopies, HR-MS spectrometry, and the electrochemical behavior of two new cluster complexes of the general formula W6Q8L6 with phosphine ligands containing a hydrophilic carboxylic group, which makes the complexes soluble in an aqueous medium. The hydrolytic stability of the clusters' aqueous solutions allows us to investigate for the first time the influence of W6-clusters on cell viability. The results obtained clearly demonstrate their very low cytotoxicity, comparable to the least-toxic clusters presented in the literature.",
keywords = "crystal structure, cytotoxicity, octahedral chalcogenide tungsten clusters, water solubility",
author = "Gassan, {Alena D.} and Ivanov, {Anton A.} and Pozmogova, {Tatiana N.} and Eltsov, {Ilia V.} and Kuratieva, {Natalia V.} and Mironov, {Yuri V.} and Shestopalov, {Michael A.}",
note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",
year = "2022",
month = aug,
day = "5",
doi = "10.3390/ijms23158734",
language = "English",
volume = "23",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "15",

}

RIS

TY - JOUR

T1 - Water-Soluble Chalcogenide W6-Clusters: On the Way to Biomedical Applications

AU - Gassan, Alena D.

AU - Ivanov, Anton A.

AU - Pozmogova, Tatiana N.

AU - Eltsov, Ilia V.

AU - Kuratieva, Natalia V.

AU - Mironov, Yuri V.

AU - Shestopalov, Michael A.

N1 - Publisher Copyright: © 2022 by the authors.

PY - 2022/8/5

Y1 - 2022/8/5

N2 - Despite the great potential of octahedral tungsten cluster complexes in fields of biomedical applications such as X-ray computed tomography or angiography, there is only one example of a water-soluble W6Q8-cluster that has been reported in the literature. Herein we present the synthesis and a detailed characterization including X-ray structural analysis, NMR, IR, UV-Vis spectroscopies, HR-MS spectrometry, and the electrochemical behavior of two new cluster complexes of the general formula W6Q8L6 with phosphine ligands containing a hydrophilic carboxylic group, which makes the complexes soluble in an aqueous medium. The hydrolytic stability of the clusters' aqueous solutions allows us to investigate for the first time the influence of W6-clusters on cell viability. The results obtained clearly demonstrate their very low cytotoxicity, comparable to the least-toxic clusters presented in the literature.

AB - Despite the great potential of octahedral tungsten cluster complexes in fields of biomedical applications such as X-ray computed tomography or angiography, there is only one example of a water-soluble W6Q8-cluster that has been reported in the literature. Herein we present the synthesis and a detailed characterization including X-ray structural analysis, NMR, IR, UV-Vis spectroscopies, HR-MS spectrometry, and the electrochemical behavior of two new cluster complexes of the general formula W6Q8L6 with phosphine ligands containing a hydrophilic carboxylic group, which makes the complexes soluble in an aqueous medium. The hydrolytic stability of the clusters' aqueous solutions allows us to investigate for the first time the influence of W6-clusters on cell viability. The results obtained clearly demonstrate their very low cytotoxicity, comparable to the least-toxic clusters presented in the literature.

KW - crystal structure

KW - cytotoxicity

KW - octahedral chalcogenide tungsten clusters

KW - water solubility

UR - http://www.scopus.com/inward/record.url?scp=85136341705&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/f6bcc89c-cfdb-3482-a59e-e8515ddb08a9/

U2 - 10.3390/ijms23158734

DO - 10.3390/ijms23158734

M3 - Article

C2 - 35955875

AN - SCOPUS:85136341705

VL - 23

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 15

M1 - 8734

ER -

ID: 37000146