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Uptake and Retention of Laser-synthesized Boron Nanoparticles in Tumor Cells and Fibroblasts. / Kasatova, A. I.; Kuzmina, K. S.; Kotelnikova, P. A. и др.

в: Doklady Biochemistry and Biophysics, Том 527, № 1, 20.04.2026, стр. 152-158.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Kasatova, AI, Kuzmina, KS, Kotelnikova, PA, Barmina, EV, Aiyyzhy, KO, Laktionov, AA, Tselikov, DI, Sozaev, IV, Lunyov, IV, Klimentov, SM, Grigoryeva, MS, Petrunya, DS, Zavjalov, EL, Taskaev, SY, Deyev, SM & Zavestovskaya, IN 2026, 'Uptake and Retention of Laser-synthesized Boron Nanoparticles in Tumor Cells and Fibroblasts', Doklady Biochemistry and Biophysics, Том. 527, № 1, стр. 152-158. https://doi.org/10.1134/S1607672925601775

APA

Kasatova, A. I., Kuzmina, K. S., Kotelnikova, P. A., Barmina, E. V., Aiyyzhy, K. O., Laktionov, A. A., Tselikov, D. I., Sozaev, I. V., Lunyov, I. V., Klimentov, S. M., Grigoryeva, M. S., Petrunya, D. S., Zavjalov, E. L., Taskaev, S. Y., Deyev, S. M., & Zavestovskaya, I. N. (2026). Uptake and Retention of Laser-synthesized Boron Nanoparticles in Tumor Cells and Fibroblasts. Doklady Biochemistry and Biophysics, 527(1), 152-158. https://doi.org/10.1134/S1607672925601775

Vancouver

Kasatova AI, Kuzmina KS, Kotelnikova PA, Barmina EV, Aiyyzhy KO, Laktionov AA и др. Uptake and Retention of Laser-synthesized Boron Nanoparticles in Tumor Cells and Fibroblasts. Doklady Biochemistry and Biophysics. 2026 апр. 20;527(1):152-158. doi: 10.1134/S1607672925601775

Author

Kasatova, A. I. ; Kuzmina, K. S. ; Kotelnikova, P. A. и др. / Uptake and Retention of Laser-synthesized Boron Nanoparticles in Tumor Cells and Fibroblasts. в: Doklady Biochemistry and Biophysics. 2026 ; Том 527, № 1. стр. 152-158.

BibTeX

@article{36016b078d0f4a17b152f0a31f24d280,
title = "Uptake and Retention of Laser-synthesized Boron Nanoparticles in Tumor Cells and Fibroblasts",
abstract = "Boron Neutron Capture Therapy (BNCT) is one of the innovative methods for treating oncological diseases. Its selectivity is based on the targeted delivery of the boron-10 isotope to tumor cells, followed by neutron irradiation, the 10B(n, α)7Li reaction occurs with a local release of 2.79 MeV of energy. Budding boron delivery agents are nanoscale systems. This study evaluated in vitro cytotoxicity, accumulation, and retention of elemental boron nanoparticles, synthesized by laser ablation and laser fragmentation, in U87 and BT474 tumor cells and BJ-5ta fibroblasts. It was shown that both types of nanoparticles exhibit low cytotoxicity at therapeutically relevant concentrations. Boron accumulation was maximal after 24 h of incubation and was significantly higher in tumor cells, especially in the BT474 cell line, compared to fibroblasts. The obtained data indicate the promise of these nanoparticles as boron delivery agents for BNCT.",
keywords = "atomic emission spectrometry, boron neutron capture therapy, cell lines, cytotoxicity, laser synthesis, nanoparticles, Бор-нейтронная захватная терапия, наночастицы, лазерный синтез, клеточные линии, цитотоксичность, атомно-эмиссионная спектрометрия",
author = "Kasatova, {A. I.} and Kuzmina, {K. S.} and Kotelnikova, {P. A.} and Barmina, {E. V.} and Aiyyzhy, {K. O.} and Laktionov, {A. A.} and Tselikov, {D. I.} and Sozaev, {I. V.} and Lunyov, {I. V.} and Klimentov, {S. M.} and Grigoryeva, {M. S.} and Petrunya, {D. S.} and Zavjalov, {E. L.} and Taskaev, {S. Yu} and Deyev, {S. M.} and Zavestovskaya, {I. N.}",
note = "Kasatova, A.I., Kuzmina, K.S., Kotelnikova, P.A. et al. Uptake and Retention of Laser-synthesized Boron Nanoparticles in Tumor Cells and Fibroblasts. Dokl Biochem Biophys 527, 152–158 (2026). – EDN QDYBUB. https://doi.org/10.1134/S1607672925601775 This work was supported by the Russian Science Foundation (Project no. 24-62-00018) within the framework of the program “Advanced Combined Technologies for Neutron Capture Therapy,” https://rscf.ru/project/24-62-00018/. The study was performed using the equipment of the “Primat” Core Facility at the NRC “Kurchatov Institute.”",
year = "2026",
month = apr,
day = "20",
doi = "10.1134/S1607672925601775",
language = "English",
volume = "527",
pages = "152--158",
journal = "Doklady Biochemistry and Biophysics",
issn = "1607-6729",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "1",

}

RIS

TY - JOUR

T1 - Uptake and Retention of Laser-synthesized Boron Nanoparticles in Tumor Cells and Fibroblasts

AU - Kasatova, A. I.

AU - Kuzmina, K. S.

AU - Kotelnikova, P. A.

AU - Barmina, E. V.

AU - Aiyyzhy, K. O.

AU - Laktionov, A. A.

AU - Tselikov, D. I.

AU - Sozaev, I. V.

AU - Lunyov, I. V.

AU - Klimentov, S. M.

AU - Grigoryeva, M. S.

AU - Petrunya, D. S.

AU - Zavjalov, E. L.

AU - Taskaev, S. Yu

AU - Deyev, S. M.

AU - Zavestovskaya, I. N.

N1 - Kasatova, A.I., Kuzmina, K.S., Kotelnikova, P.A. et al. Uptake and Retention of Laser-synthesized Boron Nanoparticles in Tumor Cells and Fibroblasts. Dokl Biochem Biophys 527, 152–158 (2026). – EDN QDYBUB. https://doi.org/10.1134/S1607672925601775 This work was supported by the Russian Science Foundation (Project no. 24-62-00018) within the framework of the program “Advanced Combined Technologies for Neutron Capture Therapy,” https://rscf.ru/project/24-62-00018/. The study was performed using the equipment of the “Primat” Core Facility at the NRC “Kurchatov Institute.”

PY - 2026/4/20

Y1 - 2026/4/20

N2 - Boron Neutron Capture Therapy (BNCT) is one of the innovative methods for treating oncological diseases. Its selectivity is based on the targeted delivery of the boron-10 isotope to tumor cells, followed by neutron irradiation, the 10B(n, α)7Li reaction occurs with a local release of 2.79 MeV of energy. Budding boron delivery agents are nanoscale systems. This study evaluated in vitro cytotoxicity, accumulation, and retention of elemental boron nanoparticles, synthesized by laser ablation and laser fragmentation, in U87 and BT474 tumor cells and BJ-5ta fibroblasts. It was shown that both types of nanoparticles exhibit low cytotoxicity at therapeutically relevant concentrations. Boron accumulation was maximal after 24 h of incubation and was significantly higher in tumor cells, especially in the BT474 cell line, compared to fibroblasts. The obtained data indicate the promise of these nanoparticles as boron delivery agents for BNCT.

AB - Boron Neutron Capture Therapy (BNCT) is one of the innovative methods for treating oncological diseases. Its selectivity is based on the targeted delivery of the boron-10 isotope to tumor cells, followed by neutron irradiation, the 10B(n, α)7Li reaction occurs with a local release of 2.79 MeV of energy. Budding boron delivery agents are nanoscale systems. This study evaluated in vitro cytotoxicity, accumulation, and retention of elemental boron nanoparticles, synthesized by laser ablation and laser fragmentation, in U87 and BT474 tumor cells and BJ-5ta fibroblasts. It was shown that both types of nanoparticles exhibit low cytotoxicity at therapeutically relevant concentrations. Boron accumulation was maximal after 24 h of incubation and was significantly higher in tumor cells, especially in the BT474 cell line, compared to fibroblasts. The obtained data indicate the promise of these nanoparticles as boron delivery agents for BNCT.

KW - atomic emission spectrometry

KW - boron neutron capture therapy

KW - cell lines

KW - cytotoxicity

KW - laser synthesis

KW - nanoparticles

KW - Бор-нейтронная захватная терапия

KW - наночастицы

KW - лазерный синтез

KW - клеточные линии

KW - цитотоксичность

KW - атомно-эмиссионная спектрометрия

UR - https://www.mendeley.com/catalogue/446a0eee-a7e6-3695-b712-707f79281b6c/

UR - https://www.scopus.com/pages/publications/105036435871

UR - https://www.elibrary.ru/item.asp?id=91537971

U2 - 10.1134/S1607672925601775

DO - 10.1134/S1607672925601775

M3 - Article

C2 - 42010075

VL - 527

SP - 152

EP - 158

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

SN - 1607-6729

IS - 1

ER -

ID: 85168349