Research output: Contribution to journal › Article › peer-review
Uptake and Retention of Laser-synthesized Boron Nanoparticles in Tumor Cells and Fibroblasts. / Kasatova, A. I.; Kuzmina, K. S.; Kotelnikova, P. A. et al.
In: Doklady Biochemistry and Biophysics, Vol. 527, No. 1, 20.04.2026, p. 152-158.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Uptake and Retention of Laser-synthesized Boron Nanoparticles in Tumor Cells and Fibroblasts
AU - Kasatova, A. I.
AU - Kuzmina, K. S.
AU - Kotelnikova, P. A.
AU - Barmina, E. V.
AU - Aiyyzhy, K. O.
AU - Laktionov, A. A.
AU - Tselikov, D. I.
AU - Sozaev, I. V.
AU - Lunyov, I. V.
AU - Klimentov, S. M.
AU - Grigoryeva, M. S.
AU - Petrunya, D. S.
AU - Zavjalov, E. L.
AU - Taskaev, S. Yu
AU - Deyev, S. M.
AU - Zavestovskaya, I. N.
N1 - Kasatova, A.I., Kuzmina, K.S., Kotelnikova, P.A. et al. Uptake and Retention of Laser-synthesized Boron Nanoparticles in Tumor Cells and Fibroblasts. Dokl Biochem Biophys 527, 152–158 (2026). – EDN QDYBUB. https://doi.org/10.1134/S1607672925601775 This work was supported by the Russian Science Foundation (Project no. 24-62-00018) within the framework of the program “Advanced Combined Technologies for Neutron Capture Therapy,” https://rscf.ru/project/24-62-00018/. The study was performed using the equipment of the “Primat” Core Facility at the NRC “Kurchatov Institute.”
PY - 2026/4/20
Y1 - 2026/4/20
N2 - Boron Neutron Capture Therapy (BNCT) is one of the innovative methods for treating oncological diseases. Its selectivity is based on the targeted delivery of the boron-10 isotope to tumor cells, followed by neutron irradiation, the 10B(n, α)7Li reaction occurs with a local release of 2.79 MeV of energy. Budding boron delivery agents are nanoscale systems. This study evaluated in vitro cytotoxicity, accumulation, and retention of elemental boron nanoparticles, synthesized by laser ablation and laser fragmentation, in U87 and BT474 tumor cells and BJ-5ta fibroblasts. It was shown that both types of nanoparticles exhibit low cytotoxicity at therapeutically relevant concentrations. Boron accumulation was maximal after 24 h of incubation and was significantly higher in tumor cells, especially in the BT474 cell line, compared to fibroblasts. The obtained data indicate the promise of these nanoparticles as boron delivery agents for BNCT.
AB - Boron Neutron Capture Therapy (BNCT) is one of the innovative methods for treating oncological diseases. Its selectivity is based on the targeted delivery of the boron-10 isotope to tumor cells, followed by neutron irradiation, the 10B(n, α)7Li reaction occurs with a local release of 2.79 MeV of energy. Budding boron delivery agents are nanoscale systems. This study evaluated in vitro cytotoxicity, accumulation, and retention of elemental boron nanoparticles, synthesized by laser ablation and laser fragmentation, in U87 and BT474 tumor cells and BJ-5ta fibroblasts. It was shown that both types of nanoparticles exhibit low cytotoxicity at therapeutically relevant concentrations. Boron accumulation was maximal after 24 h of incubation and was significantly higher in tumor cells, especially in the BT474 cell line, compared to fibroblasts. The obtained data indicate the promise of these nanoparticles as boron delivery agents for BNCT.
KW - atomic emission spectrometry
KW - boron neutron capture therapy
KW - cell lines
KW - cytotoxicity
KW - laser synthesis
KW - nanoparticles
KW - Бор-нейтронная захватная терапия
KW - наночастицы
KW - лазерный синтез
KW - клеточные линии
KW - цитотоксичность
KW - атомно-эмиссионная спектрометрия
UR - https://www.mendeley.com/catalogue/446a0eee-a7e6-3695-b712-707f79281b6c/
UR - https://www.scopus.com/pages/publications/105036435871
UR - https://www.elibrary.ru/item.asp?id=91537971
U2 - 10.1134/S1607672925601775
DO - 10.1134/S1607672925601775
M3 - Article
C2 - 42010075
VL - 527
SP - 152
EP - 158
JO - Doklady Biochemistry and Biophysics
JF - Doklady Biochemistry and Biophysics
SN - 1607-6729
IS - 1
ER -
ID: 85168349