TY - JOUR

T1 - Unusual seeding effect in the liquid-assisted high-pressure polymorphism of chlorpropamide

AU - Zakharov, B. A.

AU - Goryainov, S. V.

AU - Boldyreva, E. V.

PY - 2016

Y1 - 2016

N2 - When crystals of four polymorphs-a stable α-form and three metastable ones (β-, γ-, δ-forms)-are simultaneously present in a pressure cell, immersed in a 1:1 pentane-isopentane mixture, the least stable β-form recrystallises exclusively into the γ-form (if no δ-form seed is present) or concomitantly into the γ- and δ-forms (if a seed of the δ-form is present). However, the β-form never recrystallises to the stable α-form, even if the latter is also present as a potential seed.

AB - When crystals of four polymorphs-a stable α-form and three metastable ones (β-, γ-, δ-forms)-are simultaneously present in a pressure cell, immersed in a 1:1 pentane-isopentane mixture, the least stable β-form recrystallises exclusively into the γ-form (if no δ-form seed is present) or concomitantly into the γ- and δ-forms (if a seed of the δ-form is present). However, the β-form never recrystallises to the stable α-form, even if the latter is also present as a potential seed.

UR - http://www.scopus.com/inward/record.url?scp=84979688344&partnerID=8YFLogxK

U2 - 10.1039/c6ce00711b

DO - 10.1039/c6ce00711b

M3 - Article

AN - SCOPUS:84979688344

VL - 18

SP - 5423

EP - 5428

JO - CrystEngComm

JF - CrystEngComm

SN - 1466-8033

IS - 29

ER -