Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
Understanding neurobehavioral genetics of zebrafish. / Cheresiz, Sergey V.; Volgin, Andrey D.; Kokorina Evsyukova, Alexandra и др.
в: Journal of Neurogenetics, Том 34, № 2, 02.04.2020, стр. 203-215.Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
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TY - JOUR
T1 - Understanding neurobehavioral genetics of zebrafish
AU - Cheresiz, Sergey V.
AU - Volgin, Andrey D.
AU - Kokorina Evsyukova, Alexandra
AU - Bashirzade, Alim A.O.
AU - Demin, Konstantin A.
AU - de Abreu, Murilo S.
AU - Amstislavskaya, Tamara G.
AU - Kalueff, Allan V.
PY - 2020/4/2
Y1 - 2020/4/2
N2 - Due to its fully sequenced genome, high genetic homology to humans, external fertilization, fast development, transparency of embryos, low cost and active reproduction, the zebrafish (Danio rerio) has become a novel promising model organism in biomedicine. Zebrafish are a useful tool in genetic and neuroscience research, including linking various genetic mutations to brain mechanisms using forward and reverse genetics. These approaches have produced novel models of rare genetic CNS disorders and common brain illnesses, such as addiction, aggression, anxiety and depression. Genetically modified zebrafish also foster neuroanatomical studies, manipulating neural circuits and linking them to different behaviors. Here, we discuss recent advances in neurogenetics of zebrafish, and evaluate their unique strengths, inherent limitations and the rapidly growing potential for elucidating the conserved roles of genes in neuropsychiatric disorders.
AB - Due to its fully sequenced genome, high genetic homology to humans, external fertilization, fast development, transparency of embryos, low cost and active reproduction, the zebrafish (Danio rerio) has become a novel promising model organism in biomedicine. Zebrafish are a useful tool in genetic and neuroscience research, including linking various genetic mutations to brain mechanisms using forward and reverse genetics. These approaches have produced novel models of rare genetic CNS disorders and common brain illnesses, such as addiction, aggression, anxiety and depression. Genetically modified zebrafish also foster neuroanatomical studies, manipulating neural circuits and linking them to different behaviors. Here, we discuss recent advances in neurogenetics of zebrafish, and evaluate their unique strengths, inherent limitations and the rapidly growing potential for elucidating the conserved roles of genes in neuropsychiatric disorders.
KW - brain disorders
KW - forward genetics
KW - reverse genetics
KW - transgenic methods
KW - Zebrafish
KW - DANIO-RERIO
KW - TRANSGENIC ZEBRAFISH
KW - NEURONAL-ACTIVITY
KW - KNOCK-IN
KW - DOUBLE-STRANDED-RNA
KW - MICRORNA PATHWAY
KW - MARIE-TOOTH DISEASE
KW - ANIMAL-MODELS
KW - HOMOLOGOUS RECOMBINATION
KW - CYCLIN-DEPENDENT KINASE-5
UR - http://www.scopus.com/inward/record.url?scp=85077911137&partnerID=8YFLogxK
U2 - 10.1080/01677063.2019.1698565
DO - 10.1080/01677063.2019.1698565
M3 - Review article
C2 - 31902276
AN - SCOPUS:85077911137
VL - 34
SP - 203
EP - 215
JO - Journal of Neurogenetics
JF - Journal of Neurogenetics
SN - 0167-7063
IS - 2
ER -
ID: 23145105