TY - JOUR

T1 - Treatments with thousands therapeutic doses of meldonium failed to alter the Drosophila’s circadian clocks but negatively affected the germination of Pisum’s seeds

AU - Zakharenko, Lyudmila P.

AU - Petrovsky, Dmitriy V.

AU - Putilov, Arcady A.

PY - 2018/11/2

Y1 - 2018/11/2

N2 - Meldonium is used clinically as an anti-ischaemic drug to treat myocardial infarction and chronic heart failure, and it had become a news making substance after the banning several elite athletes including Maria Sharapova from competitions. Despite this, the majority of possible biological effects of meldonium remained unexplored. We tested two effects, I) on the circadian clocks of fruit fly (Drosophila melanogaster) and II) on the process of pea seed germination (Pisum sativum). I. Comparison of the effects of photoperiod and meldomium on the circadian rhythm of locomotor activity during the 2nd and 3rd days in constant darkness revealed the expected effect of the previous photoperiod whereas meldonium in concentrations ranged from 1 (5 mg/kg) to 10,000 therapeutic doses failed to alter the mechanism of the fly’s circadian clocks. II. A treatment with meldonium in very high concentration (2000 therapeutic doses) negatively affected the process of germination of pea seeds.

AB - Meldonium is used clinically as an anti-ischaemic drug to treat myocardial infarction and chronic heart failure, and it had become a news making substance after the banning several elite athletes including Maria Sharapova from competitions. Despite this, the majority of possible biological effects of meldonium remained unexplored. We tested two effects, I) on the circadian clocks of fruit fly (Drosophila melanogaster) and II) on the process of pea seed germination (Pisum sativum). I. Comparison of the effects of photoperiod and meldomium on the circadian rhythm of locomotor activity during the 2nd and 3rd days in constant darkness revealed the expected effect of the previous photoperiod whereas meldonium in concentrations ranged from 1 (5 mg/kg) to 10,000 therapeutic doses failed to alter the mechanism of the fly’s circadian clocks. II. A treatment with meldonium in very high concentration (2000 therapeutic doses) negatively affected the process of germination of pea seeds.

KW - 3-(2,2,2-trimethylhydrazinium)-propionate

KW - Drosophila melanogaster

KW - fruit fly

KW - germination

KW - locomotor activity

KW - Mildronate

KW - morning and evening oscillators, circadian rhythm

KW - pea

KW - photoperiod

KW - Pisum sativum

KW - Sharapóva case

KW - DRUG

KW - SLEEP

KW - PERFORMANCE

KW - Sharapova case

KW - DECREASES

KW - HEART

KW - FLY

KW - MILDRONATE

KW - RHYTHMS

KW - INHIBITOR

KW - MELANOGASTER

UR - http://www.scopus.com/inward/record.url?scp=85040966702&partnerID=8YFLogxK

U2 - 10.1080/09291016.2018.1429552

DO - 10.1080/09291016.2018.1429552

M3 - Article

AN - SCOPUS:85040966702

VL - 49

SP - 916

EP - 926

JO - Biological Rhythm Research

JF - Biological Rhythm Research

SN - 0929-1016

IS - 6

ER -