Research output: Contribution to journal › Article › peer-review
Treatments with thousands therapeutic doses of meldonium failed to alter the Drosophila’s circadian clocks but negatively affected the germination of Pisum’s seeds. / Zakharenko, Lyudmila P.; Petrovsky, Dmitriy V.; Putilov, Arcady A.
In: Biological Rhythm Research, Vol. 49, No. 6, 02.11.2018, p. 916-926.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Treatments with thousands therapeutic doses of meldonium failed to alter the Drosophila’s circadian clocks but negatively affected the germination of Pisum’s seeds
AU - Zakharenko, Lyudmila P.
AU - Petrovsky, Dmitriy V.
AU - Putilov, Arcady A.
PY - 2018/11/2
Y1 - 2018/11/2
N2 - Meldonium is used clinically as an anti-ischaemic drug to treat myocardial infarction and chronic heart failure, and it had become a news making substance after the banning several elite athletes including Maria Sharapova from competitions. Despite this, the majority of possible biological effects of meldonium remained unexplored. We tested two effects, I) on the circadian clocks of fruit fly (Drosophila melanogaster) and II) on the process of pea seed germination (Pisum sativum). I. Comparison of the effects of photoperiod and meldomium on the circadian rhythm of locomotor activity during the 2nd and 3rd days in constant darkness revealed the expected effect of the previous photoperiod whereas meldonium in concentrations ranged from 1 (5 mg/kg) to 10,000 therapeutic doses failed to alter the mechanism of the fly’s circadian clocks. II. A treatment with meldonium in very high concentration (2000 therapeutic doses) negatively affected the process of germination of pea seeds.
AB - Meldonium is used clinically as an anti-ischaemic drug to treat myocardial infarction and chronic heart failure, and it had become a news making substance after the banning several elite athletes including Maria Sharapova from competitions. Despite this, the majority of possible biological effects of meldonium remained unexplored. We tested two effects, I) on the circadian clocks of fruit fly (Drosophila melanogaster) and II) on the process of pea seed germination (Pisum sativum). I. Comparison of the effects of photoperiod and meldomium on the circadian rhythm of locomotor activity during the 2nd and 3rd days in constant darkness revealed the expected effect of the previous photoperiod whereas meldonium in concentrations ranged from 1 (5 mg/kg) to 10,000 therapeutic doses failed to alter the mechanism of the fly’s circadian clocks. II. A treatment with meldonium in very high concentration (2000 therapeutic doses) negatively affected the process of germination of pea seeds.
KW - 3-(2,2,2-trimethylhydrazinium)-propionate
KW - Drosophila melanogaster
KW - fruit fly
KW - germination
KW - locomotor activity
KW - Mildronate
KW - morning and evening oscillators, circadian rhythm
KW - pea
KW - photoperiod
KW - Pisum sativum
KW - Sharapóva case
KW - DRUG
KW - SLEEP
KW - PERFORMANCE
KW - Sharapova case
KW - DECREASES
KW - HEART
KW - FLY
KW - MILDRONATE
KW - RHYTHMS
KW - INHIBITOR
KW - MELANOGASTER
UR - http://www.scopus.com/inward/record.url?scp=85040966702&partnerID=8YFLogxK
U2 - 10.1080/09291016.2018.1429552
DO - 10.1080/09291016.2018.1429552
M3 - Article
AN - SCOPUS:85040966702
VL - 49
SP - 916
EP - 926
JO - Biological Rhythm Research
JF - Biological Rhythm Research
SN - 0929-1016
IS - 6
ER -
ID: 9327857