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Towards optical control of single blood platelet activation. / Spiryova, Darya V.; Karmatskih, Oleg Yu; Vorob'Ev, Alexei Yu и др.

SARATOV FALL MEETING 2017: LASER PHYSICS AND PHOTONICS XVIII; AND COMPUTATIONAL BIOPHYSICS AND ANALYSIS OF BIOMEDICAL DATA IV: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV. ред. / VL Derbov; DE Postnov. Том 10717 SPIE, 2018. 1071722 (Proceedings of SPIE; Том 10717).

Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференцийстатья в сборнике материалов конференциинаучнаяРецензирование

Harvard

Spiryova, DV, Karmatskih, OY, Vorob'Ev, AY & Moskalensky, AE 2018, Towards optical control of single blood platelet activation. в VL Derbov & DE Postnov (ред.), SARATOV FALL MEETING 2017: LASER PHYSICS AND PHOTONICS XVIII; AND COMPUTATIONAL BIOPHYSICS AND ANALYSIS OF BIOMEDICAL DATA IV: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV. Том. 10717, 1071722, Proceedings of SPIE, Том. 10717, SPIE, Saratov Fall Meeting 2017: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV, Saratov, Российская Федерация, 26.09.2017. https://doi.org/10.1117/12.2305477

APA

Spiryova, D. V., Karmatskih, O. Y., Vorob'Ev, A. Y., & Moskalensky, A. E. (2018). Towards optical control of single blood platelet activation. в VL. Derbov, & DE. Postnov (Ред.), SARATOV FALL MEETING 2017: LASER PHYSICS AND PHOTONICS XVIII; AND COMPUTATIONAL BIOPHYSICS AND ANALYSIS OF BIOMEDICAL DATA IV: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV (Том 10717). [1071722] (Proceedings of SPIE; Том 10717). SPIE. https://doi.org/10.1117/12.2305477

Vancouver

Spiryova DV, Karmatskih OY, Vorob'Ev AY, Moskalensky AE. Towards optical control of single blood platelet activation. в Derbov VL, Postnov DE, Редакторы, SARATOV FALL MEETING 2017: LASER PHYSICS AND PHOTONICS XVIII; AND COMPUTATIONAL BIOPHYSICS AND ANALYSIS OF BIOMEDICAL DATA IV: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV. Том 10717. SPIE. 2018. 1071722. (Proceedings of SPIE). doi: 10.1117/12.2305477

Author

Spiryova, Darya V. ; Karmatskih, Oleg Yu ; Vorob'Ev, Alexei Yu и др. / Towards optical control of single blood platelet activation. SARATOV FALL MEETING 2017: LASER PHYSICS AND PHOTONICS XVIII; AND COMPUTATIONAL BIOPHYSICS AND ANALYSIS OF BIOMEDICAL DATA IV: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV. Редактор / VL Derbov ; DE Postnov. Том 10717 SPIE, 2018. (Proceedings of SPIE).

BibTeX

@inproceedings{c983658adc2b4efe92625ab8976a4c2f,
title = "Towards optical control of single blood platelet activation",
abstract = "Blood platelets play a pivotal role in blood coagulation and in other normal and pathological processes. The understanding of fundamental mechanisms underlying their functions is very important for diagnostics and treatment. Single-cell experiments are needed for this purpose, which are complicated by insufficient spatiotemporal precision of conventional activation protocols. We present an approach to trigger single platelet activation optically, without the need of reagent mixing. This is achieved using photolabile compound, which rapidly delivers epinephrine upon UV irradiation. We demonstrated the applicability of the technique to rapidly induce platelet activation for studying dynamics of activation. The presented method may give novel fundamental knowledge about platelet functions and facilitate current research of their ability to deliver drugs to tumors or vascular injury sites.",
keywords = "Biophotonics, Caged epinephrine, Platelet activation, Single cell optical control, caged epinephrine, biophotonics, P2Y(1), SHAPE CHANGE, single cell optical control, MODEL, platelet activation",
author = "Spiryova, {Darya V.} and Karmatskih, {Oleg Yu} and Vorob'Ev, {Alexei Yu} and Moskalensky, {Alexander E.}",
note = "Publisher Copyright: {\textcopyright} 2018 SPIE.; Saratov Fall Meeting 2017: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV ; Conference date: 26-09-2017 Through 30-09-2017",
year = "2018",
month = jan,
day = "1",
doi = "10.1117/12.2305477",
language = "English",
volume = "10717",
series = "Proceedings of SPIE",
publisher = "SPIE",
editor = "VL Derbov and DE Postnov",
booktitle = "SARATOV FALL MEETING 2017: LASER PHYSICS AND PHOTONICS XVIII; AND COMPUTATIONAL BIOPHYSICS AND ANALYSIS OF BIOMEDICAL DATA IV",
address = "United States",

}

RIS

TY - GEN

T1 - Towards optical control of single blood platelet activation

AU - Spiryova, Darya V.

AU - Karmatskih, Oleg Yu

AU - Vorob'Ev, Alexei Yu

AU - Moskalensky, Alexander E.

N1 - Publisher Copyright: © 2018 SPIE.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Blood platelets play a pivotal role in blood coagulation and in other normal and pathological processes. The understanding of fundamental mechanisms underlying their functions is very important for diagnostics and treatment. Single-cell experiments are needed for this purpose, which are complicated by insufficient spatiotemporal precision of conventional activation protocols. We present an approach to trigger single platelet activation optically, without the need of reagent mixing. This is achieved using photolabile compound, which rapidly delivers epinephrine upon UV irradiation. We demonstrated the applicability of the technique to rapidly induce platelet activation for studying dynamics of activation. The presented method may give novel fundamental knowledge about platelet functions and facilitate current research of their ability to deliver drugs to tumors or vascular injury sites.

AB - Blood platelets play a pivotal role in blood coagulation and in other normal and pathological processes. The understanding of fundamental mechanisms underlying their functions is very important for diagnostics and treatment. Single-cell experiments are needed for this purpose, which are complicated by insufficient spatiotemporal precision of conventional activation protocols. We present an approach to trigger single platelet activation optically, without the need of reagent mixing. This is achieved using photolabile compound, which rapidly delivers epinephrine upon UV irradiation. We demonstrated the applicability of the technique to rapidly induce platelet activation for studying dynamics of activation. The presented method may give novel fundamental knowledge about platelet functions and facilitate current research of their ability to deliver drugs to tumors or vascular injury sites.

KW - Biophotonics

KW - Caged epinephrine

KW - Platelet activation

KW - Single cell optical control

KW - caged epinephrine

KW - biophotonics

KW - P2Y(1)

KW - SHAPE CHANGE

KW - single cell optical control

KW - MODEL

KW - platelet activation

UR - http://www.scopus.com/inward/record.url?scp=85047362362&partnerID=8YFLogxK

U2 - 10.1117/12.2305477

DO - 10.1117/12.2305477

M3 - Conference contribution

AN - SCOPUS:85047362362

VL - 10717

T3 - Proceedings of SPIE

BT - SARATOV FALL MEETING 2017: LASER PHYSICS AND PHOTONICS XVIII; AND COMPUTATIONAL BIOPHYSICS AND ANALYSIS OF BIOMEDICAL DATA IV

A2 - Derbov, VL

A2 - Postnov, DE

PB - SPIE

T2 - Saratov Fall Meeting 2017: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV

Y2 - 26 September 2017 through 30 September 2017

ER -

ID: 13541500