TY - JOUR

T1 - Through-bond and through-space radiofrequency amplification by stimulated emission of radiation

AU - Trofimov, Ivan A.

AU - Salnikov, Oleg G.

AU - Pravdivtsev, Andrey N.

AU - de Maissin, Henri

AU - Yi, Anna P.

AU - Chekmenev, Eduard Y.

AU - Hövener, Jan Bernd

AU - Schmidt, Andreas B.

AU - Koptyug, Igor V.

N1 - O.G.S., A.P.Y., and I.V.K. thank the Russian Science Foundation (grant #22-43-04426) for the support of all PHIP RASER experiments. I.A.T., H.d.M., and A.B.S. acknowledge support by the BMBF in the funding program \u201CQuantum Technologies\u2014from Basic Research to Market\u201D under the project \u201CQuE-MRT\u201D (contract number: 13N16448), the German Cancer Consortium (DKTK), the DKTK Joint Funding project \u201CHYPERBOLIC\u201D, the Research Commission of the University Medical Center Freiburg, B.E.S.T. Fluidsysteme GmbH I Swagelok Stuttgart, and the DFG (#SCHM 3694/1, #SCHM 3694/2, #SFB1479 Project ID: 441891347SFB1160). A.N.P. and J.B.H. acknowledge funding from German Federal Ministry of Education and Research (BMBF) within the framework of the e: Med research and funding concept (01ZX1915C), DFG (PR 1868/3-1, PR 1868/5-1, HO-4602/2-2, HO-4602/3, EXC2167, FOR5042, TRR287). MOIN CC was founded by a grant from the European Regional Development Fund (ERDF) and the Zukunftsprogramm Wirtschaft of Schleswig-Holstein (Project no. 122-09-053). E.Y.C. thanks the following for funding: National Science Foundation grant: CHE-1904780, NIBIB R01EB034197, NHLBI 1R21HL154032, and DOD CDMRP W81XWH-20-10576. E.Y.C. and A.B.S. thank Wayne State University for a Postdoctoral Fellow award. © 2024. The Author(s).

PY - 2024/10/23

Y1 - 2024/10/23

N2 - Radio Amplification by Stimulated Emission of Radiation (RASER) is a phenomenon observed during nuclear magnetic resonance (NMR) experiments with strongly negatively polarized systems. This phenomenon may be utilized for the production of very narrow NMR lines, background-free NMR spectroscopy, and excitation-free sensing of chemical transformations. Recently, novel methods of producing RASER by ParaHydrogen-Induced Polarization (PHIP) were introduced. Here, we show that pairwise addition of parahydrogen to various propargylic compounds induces RASER activity of other protons beyond those chemically introduced in the reaction. In high-field PHIP, negative polarization initiating RASER is transferred via intramolecular cross-relaxation. When parahydrogen is added in Earth’s field followed by adiabatic transfer to a high field, RASER activity of other protons is induced via both J-couplings and cross-relaxation. This through-bond and through-space induction of RASER holds potential for the ongoing development and expansion of RASER applications and can potentially enhance spectral resolution in two-dimensional NMR spectroscopy techniques.

AB - Radio Amplification by Stimulated Emission of Radiation (RASER) is a phenomenon observed during nuclear magnetic resonance (NMR) experiments with strongly negatively polarized systems. This phenomenon may be utilized for the production of very narrow NMR lines, background-free NMR spectroscopy, and excitation-free sensing of chemical transformations. Recently, novel methods of producing RASER by ParaHydrogen-Induced Polarization (PHIP) were introduced. Here, we show that pairwise addition of parahydrogen to various propargylic compounds induces RASER activity of other protons beyond those chemically introduced in the reaction. In high-field PHIP, negative polarization initiating RASER is transferred via intramolecular cross-relaxation. When parahydrogen is added in Earth’s field followed by adiabatic transfer to a high field, RASER activity of other protons is induced via both J-couplings and cross-relaxation. This through-bond and through-space induction of RASER holds potential for the ongoing development and expansion of RASER applications and can potentially enhance spectral resolution in two-dimensional NMR spectroscopy techniques.

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85206681825&origin=inward&txGid=ca63369c4b93ef5517f7f74c20505c3c

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:001333847100001

UR - https://www.mendeley.com/catalogue/71df6c78-32b3-3c4e-9287-2b3d3def6ffa/

U2 - 10.1038/s42004-024-01313-0

DO - 10.1038/s42004-024-01313-0

M3 - Article

C2 - 39414912

VL - 7

SP - 235

JO - Communications Chemistry

JF - Communications Chemistry

SN - 2399-3669

IS - 1

M1 - 235

ER -