Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Thermodynamic aspects of freeze-drying : A case study of an “organic solvent–water” system. / Ogienko, A. G.; Drebushchak, V. A.; Bogdanova, E. G. и др.
в: Journal of Thermal Analysis and Calorimetry, Том 127, № 2, 01.02.2017, стр. 1593-1604.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Thermodynamic aspects of freeze-drying
T2 - A case study of an “organic solvent–water” system
AU - Ogienko, A. G.
AU - Drebushchak, V. A.
AU - Bogdanova, E. G.
AU - Yunoshev, A. S.
AU - Ogienko, A. A.
AU - Boldyreva, E. V.
AU - Manakov, A. Yu
N1 - Publisher Copyright: © 2016, Akadémiai Kiadó, Budapest, Hungary.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Aqueous solutions of glycine and tetrahydrofuran (THF) were frozen under variable conditions and subsequently annealed. The phases that resulted from this process were studied by X-ray diffraction, DSC and cryotemperature SEM. Under conditions achieved in common laboratory freeze-dryers, the THF clathrate hydrate of cubic structure II was formed in near-quantitative yields. The temperature–composition state diagram for the THF–water–β-glycine systems suggests that the critical temperature of the primary drying stage is the temperature of the four-phase peritectic reaction (269 K), and not the temperature of the congruent melting of the THF hydrate in the THF–water system (278 K). Freeze-drying is shown to go much faster if aqueous solutions are substituted for THF–water solutions. This finding is of great importance for practical applications, including pharmaceutical drug formulation.
AB - Aqueous solutions of glycine and tetrahydrofuran (THF) were frozen under variable conditions and subsequently annealed. The phases that resulted from this process were studied by X-ray diffraction, DSC and cryotemperature SEM. Under conditions achieved in common laboratory freeze-dryers, the THF clathrate hydrate of cubic structure II was formed in near-quantitative yields. The temperature–composition state diagram for the THF–water–β-glycine systems suggests that the critical temperature of the primary drying stage is the temperature of the four-phase peritectic reaction (269 K), and not the temperature of the congruent melting of the THF hydrate in the THF–water system (278 K). Freeze-drying is shown to go much faster if aqueous solutions are substituted for THF–water solutions. This finding is of great importance for practical applications, including pharmaceutical drug formulation.
KW - Cryotemperature SEM
KW - DSC
KW - Freeze-drying
KW - Phase diagram
KW - X-ray diffraction
KW - COSOLVENT SYSTEMS
KW - TERTIARY BUTYL ALCOHOL
KW - THERMAL-EXPANSION
KW - DRUG-DELIVERY
KW - PARTICLE ENGINEERING TECHNOLOGY
KW - ICE MORPHOLOGY
KW - FROZEN-SOLUTIONS
KW - TETRAHYDROFURAN CLATHRATE HYDRATE
KW - HEAT-CAPACITIES
KW - ENHANCE DISSOLUTION
UR - http://www.scopus.com/inward/record.url?scp=85006486804&partnerID=8YFLogxK
U2 - 10.1007/s10973-016-6003-8
DO - 10.1007/s10973-016-6003-8
M3 - Article
AN - SCOPUS:85006486804
VL - 127
SP - 1593
EP - 1604
JO - Journal of Thermal Analysis and Calorimetry
JF - Journal of Thermal Analysis and Calorimetry
SN - 1388-6150
IS - 2
ER -
ID: 9013946