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Thermodynamic aspects of freeze-drying : A case study of an “organic solvent–water” system. / Ogienko, A. G.; Drebushchak, V. A.; Bogdanova, E. G. et al.

In: Journal of Thermal Analysis and Calorimetry, Vol. 127, No. 2, 01.02.2017, p. 1593-1604.

Research output: Contribution to journal › Article › peer-review

Harvard

Ogienko, AG, Drebushchak, VA, Bogdanova, EG, Yunoshev, AS, Ogienko, AA, Boldyreva, EV & Manakov, AY 2017, 'Thermodynamic aspects of freeze-drying: A case study of an “organic solvent–water” system', Journal of Thermal Analysis and Calorimetry, vol. 127, no. 2, pp. 1593-1604. https://doi.org/10.1007/s10973-016-6003-8

APA

Ogienko, A. G., Drebushchak, V. A., Bogdanova, E. G., Yunoshev, A. S., Ogienko, A. A., Boldyreva, E. V., & Manakov, A. Y. (2017). Thermodynamic aspects of freeze-drying: A case study of an “organic solvent–water” system. Journal of Thermal Analysis and Calorimetry, 127(2), 1593-1604. https://doi.org/10.1007/s10973-016-6003-8

Vancouver

Ogienko AG, Drebushchak VA, Bogdanova EG, Yunoshev AS, Ogienko AA, Boldyreva EV et al. Thermodynamic aspects of freeze-drying: A case study of an “organic solvent–water” system. Journal of Thermal Analysis and Calorimetry. 2017 Feb 1;127(2):1593-1604. doi: 10.1007/s10973-016-6003-8

Author

Ogienko, A. G. ; Drebushchak, V. A. ; Bogdanova, E. G. et al. / Thermodynamic aspects of freeze-drying : A case study of an “organic solvent–water” system. In: Journal of Thermal Analysis and Calorimetry. 2017 ; Vol. 127, No. 2. pp. 1593-1604.

BibTeX

@article{16300da50b6642e3b3d693e9951a9aa9,
title = "Thermodynamic aspects of freeze-drying: A case study of an “organic solvent–water” system",
abstract = "Aqueous solutions of glycine and tetrahydrofuran (THF) were frozen under variable conditions and subsequently annealed. The phases that resulted from this process were studied by X-ray diffraction, DSC and cryotemperature SEM. Under conditions achieved in common laboratory freeze-dryers, the THF clathrate hydrate of cubic structure II was formed in near-quantitative yields. The temperature–composition state diagram for the THF–water–β-glycine systems suggests that the critical temperature of the primary drying stage is the temperature of the four-phase peritectic reaction (269 K), and not the temperature of the congruent melting of the THF hydrate in the THF–water system (278 K). Freeze-drying is shown to go much faster if aqueous solutions are substituted for THF–water solutions. This finding is of great importance for practical applications, including pharmaceutical drug formulation.",
keywords = "Cryotemperature SEM, DSC, Freeze-drying, Phase diagram, X-ray diffraction, COSOLVENT SYSTEMS, TERTIARY BUTYL ALCOHOL, THERMAL-EXPANSION, DRUG-DELIVERY, PARTICLE ENGINEERING TECHNOLOGY, ICE MORPHOLOGY, FROZEN-SOLUTIONS, TETRAHYDROFURAN CLATHRATE HYDRATE, HEAT-CAPACITIES, ENHANCE DISSOLUTION",
author = "Ogienko, {A. G.} and Drebushchak, {V. A.} and Bogdanova, {E. G.} and Yunoshev, {A. S.} and Ogienko, {A. A.} and Boldyreva, {E. V.} and Manakov, {A. Yu}",
note = "Publisher Copyright: {\textcopyright} 2016, Akad{\'e}miai Kiad{\'o}, Budapest, Hungary.",
year = "2017",
month = feb,
day = "1",
doi = "10.1007/s10973-016-6003-8",
language = "English",
volume = "127",
pages = "1593--1604",
journal = "Journal of Thermal Analysis and Calorimetry",
issn = "1388-6150",
publisher = "Springer Nature",
number = "2",

}

RIS

TY - JOUR

T1 - Thermodynamic aspects of freeze-drying

T2 - A case study of an “organic solvent–water” system

AU - Ogienko, A. G.

AU - Drebushchak, V. A.

AU - Bogdanova, E. G.

AU - Yunoshev, A. S.

AU - Ogienko, A. A.

AU - Boldyreva, E. V.

AU - Manakov, A. Yu

N1 - Publisher Copyright: © 2016, Akadémiai Kiadó, Budapest, Hungary.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Aqueous solutions of glycine and tetrahydrofuran (THF) were frozen under variable conditions and subsequently annealed. The phases that resulted from this process were studied by X-ray diffraction, DSC and cryotemperature SEM. Under conditions achieved in common laboratory freeze-dryers, the THF clathrate hydrate of cubic structure II was formed in near-quantitative yields. The temperature–composition state diagram for the THF–water–β-glycine systems suggests that the critical temperature of the primary drying stage is the temperature of the four-phase peritectic reaction (269 K), and not the temperature of the congruent melting of the THF hydrate in the THF–water system (278 K). Freeze-drying is shown to go much faster if aqueous solutions are substituted for THF–water solutions. This finding is of great importance for practical applications, including pharmaceutical drug formulation.

AB - Aqueous solutions of glycine and tetrahydrofuran (THF) were frozen under variable conditions and subsequently annealed. The phases that resulted from this process were studied by X-ray diffraction, DSC and cryotemperature SEM. Under conditions achieved in common laboratory freeze-dryers, the THF clathrate hydrate of cubic structure II was formed in near-quantitative yields. The temperature–composition state diagram for the THF–water–β-glycine systems suggests that the critical temperature of the primary drying stage is the temperature of the four-phase peritectic reaction (269 K), and not the temperature of the congruent melting of the THF hydrate in the THF–water system (278 K). Freeze-drying is shown to go much faster if aqueous solutions are substituted for THF–water solutions. This finding is of great importance for practical applications, including pharmaceutical drug formulation.

KW - Cryotemperature SEM

KW - DSC

KW - Freeze-drying

KW - Phase diagram

KW - X-ray diffraction

KW - COSOLVENT SYSTEMS

KW - TERTIARY BUTYL ALCOHOL

KW - THERMAL-EXPANSION

KW - DRUG-DELIVERY

KW - PARTICLE ENGINEERING TECHNOLOGY

KW - ICE MORPHOLOGY

KW - FROZEN-SOLUTIONS

KW - TETRAHYDROFURAN CLATHRATE HYDRATE

KW - HEAT-CAPACITIES

KW - ENHANCE DISSOLUTION

UR - http://www.scopus.com/inward/record.url?scp=85006486804&partnerID=8YFLogxK

U2 - 10.1007/s10973-016-6003-8

DO - 10.1007/s10973-016-6003-8

M3 - Article

AN - SCOPUS:85006486804

VL - 127

SP - 1593

EP - 1604

JO - Journal of Thermal Analysis and Calorimetry

JF - Journal of Thermal Analysis and Calorimetry

SN - 1388-6150

IS - 2

ER -

ID: 9013946