TY - JOUR

T1 - The functional properties of Mg-Zn-X biodegradable magnesium alloys

AU - Merson, Dmitry

AU - Brilevsky, Alexander

AU - Myagkikh, Pavel

AU - Tarkova, Alexandra

AU - Prokhorikhin, Alexei

AU - Kretov, Evgeny

AU - Frolova, Tatiana

AU - Vinogradov, Alexei

N1 - Publisher Copyright: © 2020 by the authors. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/1/23

Y1 - 2020/1/23

N2 - The implantation of metallic devices in orthopaedic surgical procedures and coronary angioplasty is associated with the risk of various adverse events: (i) mechanical (premature failure), (ii) chemo-mechanical (corrosion and corrosion-fatigue degradation) and (iii) biomedical (chronic local inflammatory reactions, tissue necrosis, etc.). In this regard, the development of biodegradable implants/stents, which provide the necessary mechanical support for the healing period of the bone or the vessel wall and then are completely resorbed, has bright prospects. Magnesium alloys are the most suitable candidates for that purpose due to their superior mechanical performance, bioresorbability and biocompatibility. This article presents the results of the comparative research on several wrought biodegradable alloys, assessing their potential for biomedical applications. The Mg-Zn-X alloys with different chemical compositions and microstructures were produced using severe plastic deformation techniques. Functional properties pivotal for biomedical applications-mechanical strength, in vitro corrosion resistance and cytotoxic activity-were included in the focus of the study. Excellent mechanical performance and low cytotoxic effects are documented for all alloys with a notable exception for one of two Mg-Zn-Zr alloys. The in vitro corrosion resistance is, however, below expectations due to critical impurities, and this property has yet to be drastically improved through the cleaner materials fabrication processing before they can be considered for biomedical applications.

AB - The implantation of metallic devices in orthopaedic surgical procedures and coronary angioplasty is associated with the risk of various adverse events: (i) mechanical (premature failure), (ii) chemo-mechanical (corrosion and corrosion-fatigue degradation) and (iii) biomedical (chronic local inflammatory reactions, tissue necrosis, etc.). In this regard, the development of biodegradable implants/stents, which provide the necessary mechanical support for the healing period of the bone or the vessel wall and then are completely resorbed, has bright prospects. Magnesium alloys are the most suitable candidates for that purpose due to their superior mechanical performance, bioresorbability and biocompatibility. This article presents the results of the comparative research on several wrought biodegradable alloys, assessing their potential for biomedical applications. The Mg-Zn-X alloys with different chemical compositions and microstructures were produced using severe plastic deformation techniques. Functional properties pivotal for biomedical applications-mechanical strength, in vitro corrosion resistance and cytotoxic activity-were included in the focus of the study. Excellent mechanical performance and low cytotoxic effects are documented for all alloys with a notable exception for one of two Mg-Zn-Zr alloys. The in vitro corrosion resistance is, however, below expectations due to critical impurities, and this property has yet to be drastically improved through the cleaner materials fabrication processing before they can be considered for biomedical applications.

KW - Bioresorbabale implants

KW - Corrosion

KW - Cytotoxicity

KW - Deformation processing

KW - Magnesium alloy

KW - Mechanical properties

KW - Microstructure

KW - VITRO

KW - bioresorbabale implants

KW - magnesium alloy

KW - corrosion

KW - microstructure

KW - IN-VIVO DEGRADATION

KW - deformation processing

KW - STRENGTH

KW - GRAIN-SIZE

KW - MECHANICAL-PROPERTIES

KW - mechanical properties

KW - DYNAMIC RECRYSTALLIZATION

KW - CORROSION-RESISTANCE

KW - SEVERE PLASTIC-DEFORMATION

KW - INTEGRATED EXTRUSION

KW - cytotoxicity

KW - MICROSTRUCTURE

UR - http://www.scopus.com/inward/record.url?scp=85079592784&partnerID=8YFLogxK

U2 - 10.3390/ma13030544

DO - 10.3390/ma13030544

M3 - Article

C2 - 31979227

AN - SCOPUS:85079592784

VL - 13

JO - Materials

JF - Materials

SN - 1996-1944

IS - 3

M1 - 544

ER -