Research output: Contribution to journal › Article › peer-review
The functional properties of Mg-Zn-X biodegradable magnesium alloys. / Merson, Dmitry; Brilevsky, Alexander; Myagkikh, Pavel et al.
In: Materials, Vol. 13, No. 3, 544, 23.01.2020.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - The functional properties of Mg-Zn-X biodegradable magnesium alloys
AU - Merson, Dmitry
AU - Brilevsky, Alexander
AU - Myagkikh, Pavel
AU - Tarkova, Alexandra
AU - Prokhorikhin, Alexei
AU - Kretov, Evgeny
AU - Frolova, Tatiana
AU - Vinogradov, Alexei
N1 - Publisher Copyright: © 2020 by the authors. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/1/23
Y1 - 2020/1/23
N2 - The implantation of metallic devices in orthopaedic surgical procedures and coronary angioplasty is associated with the risk of various adverse events: (i) mechanical (premature failure), (ii) chemo-mechanical (corrosion and corrosion-fatigue degradation) and (iii) biomedical (chronic local inflammatory reactions, tissue necrosis, etc.). In this regard, the development of biodegradable implants/stents, which provide the necessary mechanical support for the healing period of the bone or the vessel wall and then are completely resorbed, has bright prospects. Magnesium alloys are the most suitable candidates for that purpose due to their superior mechanical performance, bioresorbability and biocompatibility. This article presents the results of the comparative research on several wrought biodegradable alloys, assessing their potential for biomedical applications. The Mg-Zn-X alloys with different chemical compositions and microstructures were produced using severe plastic deformation techniques. Functional properties pivotal for biomedical applications-mechanical strength, in vitro corrosion resistance and cytotoxic activity-were included in the focus of the study. Excellent mechanical performance and low cytotoxic effects are documented for all alloys with a notable exception for one of two Mg-Zn-Zr alloys. The in vitro corrosion resistance is, however, below expectations due to critical impurities, and this property has yet to be drastically improved through the cleaner materials fabrication processing before they can be considered for biomedical applications.
AB - The implantation of metallic devices in orthopaedic surgical procedures and coronary angioplasty is associated with the risk of various adverse events: (i) mechanical (premature failure), (ii) chemo-mechanical (corrosion and corrosion-fatigue degradation) and (iii) biomedical (chronic local inflammatory reactions, tissue necrosis, etc.). In this regard, the development of biodegradable implants/stents, which provide the necessary mechanical support for the healing period of the bone or the vessel wall and then are completely resorbed, has bright prospects. Magnesium alloys are the most suitable candidates for that purpose due to their superior mechanical performance, bioresorbability and biocompatibility. This article presents the results of the comparative research on several wrought biodegradable alloys, assessing their potential for biomedical applications. The Mg-Zn-X alloys with different chemical compositions and microstructures were produced using severe plastic deformation techniques. Functional properties pivotal for biomedical applications-mechanical strength, in vitro corrosion resistance and cytotoxic activity-were included in the focus of the study. Excellent mechanical performance and low cytotoxic effects are documented for all alloys with a notable exception for one of two Mg-Zn-Zr alloys. The in vitro corrosion resistance is, however, below expectations due to critical impurities, and this property has yet to be drastically improved through the cleaner materials fabrication processing before they can be considered for biomedical applications.
KW - Bioresorbabale implants
KW - Corrosion
KW - Cytotoxicity
KW - Deformation processing
KW - Magnesium alloy
KW - Mechanical properties
KW - Microstructure
KW - VITRO
KW - bioresorbabale implants
KW - magnesium alloy
KW - corrosion
KW - microstructure
KW - IN-VIVO DEGRADATION
KW - deformation processing
KW - STRENGTH
KW - GRAIN-SIZE
KW - MECHANICAL-PROPERTIES
KW - mechanical properties
KW - DYNAMIC RECRYSTALLIZATION
KW - CORROSION-RESISTANCE
KW - SEVERE PLASTIC-DEFORMATION
KW - INTEGRATED EXTRUSION
KW - cytotoxicity
KW - MICROSTRUCTURE
UR - http://www.scopus.com/inward/record.url?scp=85079592784&partnerID=8YFLogxK
U2 - 10.3390/ma13030544
DO - 10.3390/ma13030544
M3 - Article
C2 - 31979227
AN - SCOPUS:85079592784
VL - 13
JO - Materials
JF - Materials
SN - 1996-1944
IS - 3
M1 - 544
ER -
ID: 23594762