Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › статья в сборнике материалов конференции › научная › Рецензирование
The confocal microscopy for assessement of transdermal transport of the photosensitizer chlorin E6 after non-ablative photothermolysis. / Nikonov, Sergey; Chernopyatov, Danila; Nimaev, Vadim и др.
Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021. Institute of Electrical and Electronics Engineers Inc., 2021. стр. 390-393 9496022 (Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021).Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › статья в сборнике материалов конференции › научная › Рецензирование
}
TY - GEN
T1 - The confocal microscopy for assessement of transdermal transport of the photosensitizer chlorin E6 after non-ablative photothermolysis
AU - Nikonov, Sergey
AU - Chernopyatov, Danila
AU - Nimaev, Vadim
AU - Bgatova, Nataliya
AU - Taskaeva, Iuliia
AU - Mayorov, Alexander
N1 - Publisher Copyright: © 2021 IEEE.
PY - 2021/5/26
Y1 - 2021/5/26
N2 - Transdermal delivery of the drug using laser nonablative photothermolysis of the epidermis has the prospect of clinical application, but requires further study of the specifics of the drug penetration into all layers of the skin and subcutaneous space. In our work, we demonstrate a method for determining the drug Radagel containing chlorin E6 in the skin layers using confocal microscopy and light energy in the spectrum, which allows us to initiate fluorescence and record its intensity. Nonablative photothermolysis provided a pronounced increase in the fluorescence of chlorin E6 in the deep layers of the dermis, and quantitative determination of the fluorescence intensity allowed us to calculate the coefficient of transdermal transport of the drug, which increased by 27 times after photothermolysis.
AB - Transdermal delivery of the drug using laser nonablative photothermolysis of the epidermis has the prospect of clinical application, but requires further study of the specifics of the drug penetration into all layers of the skin and subcutaneous space. In our work, we demonstrate a method for determining the drug Radagel containing chlorin E6 in the skin layers using confocal microscopy and light energy in the spectrum, which allows us to initiate fluorescence and record its intensity. Nonablative photothermolysis provided a pronounced increase in the fluorescence of chlorin E6 in the deep layers of the dermis, and quantitative determination of the fluorescence intensity allowed us to calculate the coefficient of transdermal transport of the drug, which increased by 27 times after photothermolysis.
KW - chlorin E6
KW - laser energy
KW - photosensitizer
KW - photothermolysis
KW - transdermal transport
KW - transdermal transport coefficient
UR - http://www.scopus.com/inward/record.url?scp=85112369049&partnerID=8YFLogxK
U2 - 10.1109/CSGB53040.2021.9496022
DO - 10.1109/CSGB53040.2021.9496022
M3 - Conference contribution
AN - SCOPUS:85112369049
T3 - Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021
SP - 390
EP - 393
BT - Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021
Y2 - 26 May 2021 through 28 May 2021
ER -
ID: 29295136