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The confocal microscopy for assessement of transdermal transport of the photosensitizer chlorin E6 after non-ablative photothermolysis. / Nikonov, Sergey; Chernopyatov, Danila; Nimaev, Vadim et al.

Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021. Institute of Electrical and Electronics Engineers Inc., 2021. p. 390-393 9496022 (Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review

Harvard

Nikonov, S, Chernopyatov, D, Nimaev, V, Bgatova, N, Taskaeva, I & Mayorov, A 2021, The confocal microscopy for assessement of transdermal transport of the photosensitizer chlorin E6 after non-ablative photothermolysis. in Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021., 9496022, Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021, Institute of Electrical and Electronics Engineers Inc., pp. 390-393, 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021, Novosibirsk, Yekaterinburg, Russian Federation, 26.05.2021. https://doi.org/10.1109/CSGB53040.2021.9496022

APA

Nikonov, S., Chernopyatov, D., Nimaev, V., Bgatova, N., Taskaeva, I., & Mayorov, A. (2021). The confocal microscopy for assessement of transdermal transport of the photosensitizer chlorin E6 after non-ablative photothermolysis. In Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021 (pp. 390-393). [9496022] (Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CSGB53040.2021.9496022

Vancouver

Nikonov S, Chernopyatov D, Nimaev V, Bgatova N, Taskaeva I, Mayorov A. The confocal microscopy for assessement of transdermal transport of the photosensitizer chlorin E6 after non-ablative photothermolysis. In Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021. Institute of Electrical and Electronics Engineers Inc. 2021. p. 390-393. 9496022. (Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021). doi: 10.1109/CSGB53040.2021.9496022

Author

Nikonov, Sergey ; Chernopyatov, Danila ; Nimaev, Vadim et al. / The confocal microscopy for assessement of transdermal transport of the photosensitizer chlorin E6 after non-ablative photothermolysis. Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021. Institute of Electrical and Electronics Engineers Inc., 2021. pp. 390-393 (Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021).

BibTeX

@inproceedings{11e0f3ad3ac74eacaff842ea17abaab2,
title = "The confocal microscopy for assessement of transdermal transport of the photosensitizer chlorin E6 after non-ablative photothermolysis",
abstract = "Transdermal delivery of the drug using laser nonablative photothermolysis of the epidermis has the prospect of clinical application, but requires further study of the specifics of the drug penetration into all layers of the skin and subcutaneous space. In our work, we demonstrate a method for determining the drug Radagel containing chlorin E6 in the skin layers using confocal microscopy and light energy in the spectrum, which allows us to initiate fluorescence and record its intensity. Nonablative photothermolysis provided a pronounced increase in the fluorescence of chlorin E6 in the deep layers of the dermis, and quantitative determination of the fluorescence intensity allowed us to calculate the coefficient of transdermal transport of the drug, which increased by 27 times after photothermolysis. ",
keywords = "chlorin E6, laser energy, photosensitizer, photothermolysis, transdermal transport, transdermal transport coefficient",
author = "Sergey Nikonov and Danila Chernopyatov and Vadim Nimaev and Nataliya Bgatova and Iuliia Taskaeva and Alexander Mayorov",
note = "Publisher Copyright: {\textcopyright} 2021 IEEE.; 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021 ; Conference date: 26-05-2021 Through 28-05-2021",
year = "2021",
month = may,
day = "26",
doi = "10.1109/CSGB53040.2021.9496022",
language = "English",
series = "Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "390--393",
booktitle = "Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021",
address = "United States",

}

RIS

TY - GEN

T1 - The confocal microscopy for assessement of transdermal transport of the photosensitizer chlorin E6 after non-ablative photothermolysis

AU - Nikonov, Sergey

AU - Chernopyatov, Danila

AU - Nimaev, Vadim

AU - Bgatova, Nataliya

AU - Taskaeva, Iuliia

AU - Mayorov, Alexander

N1 - Publisher Copyright: © 2021 IEEE.

PY - 2021/5/26

Y1 - 2021/5/26

N2 - Transdermal delivery of the drug using laser nonablative photothermolysis of the epidermis has the prospect of clinical application, but requires further study of the specifics of the drug penetration into all layers of the skin and subcutaneous space. In our work, we demonstrate a method for determining the drug Radagel containing chlorin E6 in the skin layers using confocal microscopy and light energy in the spectrum, which allows us to initiate fluorescence and record its intensity. Nonablative photothermolysis provided a pronounced increase in the fluorescence of chlorin E6 in the deep layers of the dermis, and quantitative determination of the fluorescence intensity allowed us to calculate the coefficient of transdermal transport of the drug, which increased by 27 times after photothermolysis.

AB - Transdermal delivery of the drug using laser nonablative photothermolysis of the epidermis has the prospect of clinical application, but requires further study of the specifics of the drug penetration into all layers of the skin and subcutaneous space. In our work, we demonstrate a method for determining the drug Radagel containing chlorin E6 in the skin layers using confocal microscopy and light energy in the spectrum, which allows us to initiate fluorescence and record its intensity. Nonablative photothermolysis provided a pronounced increase in the fluorescence of chlorin E6 in the deep layers of the dermis, and quantitative determination of the fluorescence intensity allowed us to calculate the coefficient of transdermal transport of the drug, which increased by 27 times after photothermolysis.

KW - chlorin E6

KW - laser energy

KW - photosensitizer

KW - photothermolysis

KW - transdermal transport

KW - transdermal transport coefficient

UR - http://www.scopus.com/inward/record.url?scp=85112369049&partnerID=8YFLogxK

U2 - 10.1109/CSGB53040.2021.9496022

DO - 10.1109/CSGB53040.2021.9496022

M3 - Conference contribution

AN - SCOPUS:85112369049

T3 - Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021

SP - 390

EP - 393

BT - Proceedings - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2021 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2021

Y2 - 26 May 2021 through 28 May 2021

ER -

ID: 29295136