TY - JOUR

T1 - Synthesis of High-Purity Basic Bismuth(III) Succinate as a Pharmaceutical Substance

AU - Timakova, E. V.

AU - Bun’kova, E. I.

AU - Afonina, L. I.

AU - Yukhin, Yu M.

AU - Volodin, V. A.

N1 - Funding Information: The authors are grateful to the Center for Shared Use High Technologies and Nanosystems Analytics at the Novosibirsk State University for the opportunity to use the equipment for recording the Raman spectra. Publisher Copyright: © 2021, Pleiades Publishing, Ltd.

PY - 2021/7

Y1 - 2021/7

N2 - Reactions of solid trihydroxopentaoxohexabismuth(III) pentanitrate trihydrate [Bi6O5(OH)3](NO3)5·3H2O and monoclinic bismuth oxide α-Bi2O3 with a succinic acid solution were studied with the aim of preparing a pharmaceutical substance, basic bismuth succinate С2Н4(СООBiO)2, meeting high purity requirements concerning the content of impurity metals. A procedure for preparing basic bismuth(III) succinate was suggested; it involves hydrolytic treatment of a process solution of bismuth in nitric acid to obtain high-purity [Bi6O5(OH)3](NO3)5·3H2O, its treatment with a NaOH solution to obtain finely crystalline α-Bi2O3, and the subsequent reaction of bismuth oxide with a succinic acid solution. The product composition was confirmed by X-ray diffraction, chemical analysis, IR and Raman spectroscopy, and thermal gravimetric analysis; the content of impurity metals was determined by the atomic absorption method.

AB - Reactions of solid trihydroxopentaoxohexabismuth(III) pentanitrate trihydrate [Bi6O5(OH)3](NO3)5·3H2O and monoclinic bismuth oxide α-Bi2O3 with a succinic acid solution were studied with the aim of preparing a pharmaceutical substance, basic bismuth succinate С2Н4(СООBiO)2, meeting high purity requirements concerning the content of impurity metals. A procedure for preparing basic bismuth(III) succinate was suggested; it involves hydrolytic treatment of a process solution of bismuth in nitric acid to obtain high-purity [Bi6O5(OH)3](NO3)5·3H2O, its treatment with a NaOH solution to obtain finely crystalline α-Bi2O3, and the subsequent reaction of bismuth oxide with a succinic acid solution. The product composition was confirmed by X-ray diffraction, chemical analysis, IR and Raman spectroscopy, and thermal gravimetric analysis; the content of impurity metals was determined by the atomic absorption method.

KW - basic bismuth(III) succinate

KW - bismuth(III) oxide

KW - bismuth(III) oxonitrate

KW - impurity metals

KW - pharmaceutical substance

KW - preparation procedure

KW - succinic acid

UR - http://www.scopus.com/inward/record.url?scp=85116434029&partnerID=8YFLogxK

U2 - 10.1134/S1070427221070077

DO - 10.1134/S1070427221070077

M3 - Article

AN - SCOPUS:85116434029

VL - 94

SP - 911

EP - 919

JO - Russian Journal of Applied Chemistry

JF - Russian Journal of Applied Chemistry

SN - 1070-4272

IS - 7

ER -