TY - JOUR

T1 - Synthesis and magnetic and cytotoxic properties of copper(II) halide complexes with 1,2,4-triazolo[1,5-

T2 - A] benzimidazoles

AU - Lavrenova, L. G.

AU - Kuz'menko, T. A.

AU - Ivanova, A. D.

AU - Smolentsev, A. I.

AU - Komarov, V. Yu

AU - Bogomyakov, A. S.

AU - Sheludyakova, L. A.

AU - Vorontsova, E. V.

PY - 2017/6/7

Y1 - 2017/6/7

N2 - Coordination compounds based on copper(ii) halides with 4H-1,2,4-triazolo[1,5-a]benzimidazole (L1), 3-methyl-1,2,4-triazolo[1,5-a]benzimidazole (L2), and 4-methyl-1,2,4-triazolo[1,5-a]benzimidazole (L3) with the compositions [Cu(L1)2(Hal)2]·nH2O (Hal = Cl-, n = 0.5 (I) Br-, n = 1 (II)); [Cu(L2)2Cl2] (III), [Cu(L3)2Cl2] (IV) and [Cu(L3)2Br2(H2O)]·2H2O (V) were synthesized. The compounds were characterized using X-ray diffraction, UV-Vis spectroscopy (diffuse reflectance spectra), infrared spectroscopy, and static magnetic susceptibility measurements. By means of X-ray diffraction structural analysis, crystal structures were determined for the [Cu(L3)2(Hal)2(H2O)]·2H2O complexes, where Hal = Cl- (IVa) or Br- (V). Cytotoxic effects of the complexes and ligands on the cell line Hep-2 were then studied, and we found that the copper(ii) complex with ligands L1-L3 leads to a considerable enhancement of cytotoxicity.

AB - Coordination compounds based on copper(ii) halides with 4H-1,2,4-triazolo[1,5-a]benzimidazole (L1), 3-methyl-1,2,4-triazolo[1,5-a]benzimidazole (L2), and 4-methyl-1,2,4-triazolo[1,5-a]benzimidazole (L3) with the compositions [Cu(L1)2(Hal)2]·nH2O (Hal = Cl-, n = 0.5 (I) Br-, n = 1 (II)); [Cu(L2)2Cl2] (III), [Cu(L3)2Cl2] (IV) and [Cu(L3)2Br2(H2O)]·2H2O (V) were synthesized. The compounds were characterized using X-ray diffraction, UV-Vis spectroscopy (diffuse reflectance spectra), infrared spectroscopy, and static magnetic susceptibility measurements. By means of X-ray diffraction structural analysis, crystal structures were determined for the [Cu(L3)2(Hal)2(H2O)]·2H2O complexes, where Hal = Cl- (IVa) or Br- (V). Cytotoxic effects of the complexes and ligands on the cell line Hep-2 were then studied, and we found that the copper(ii) complex with ligands L1-L3 leads to a considerable enhancement of cytotoxicity.

KW - DERIVATIVES

UR - http://www.scopus.com/inward/record.url?scp=85021633384&partnerID=8YFLogxK

U2 - 10.1039/c7nj00533d

DO - 10.1039/c7nj00533d

M3 - Article

AN - SCOPUS:85021633384

VL - 41

SP - 4341

EP - 4347

JO - New Journal of Chemistry

JF - New Journal of Chemistry

SN - 1144-0546

IS - 11

ER -