Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Synthesis and Antibacterial Activity of Caffeine Derivatives Containing Amino-Acid Fragments. / Reshetnikov, D. V.; Burova, L. G.; Rybalova, T. V. и др.
в: Chemistry of Natural Compounds, Том 58, № 5, 09.2022, стр. 908-915.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Synthesis and Antibacterial Activity of Caffeine Derivatives Containing Amino-Acid Fragments
AU - Reshetnikov, D. V.
AU - Burova, L. G.
AU - Rybalova, T. V.
AU - Bondareva, E. A.
AU - Patrushev, S. S.
AU - Evstropov, A. N.
AU - Shults, E. E.
N1 - Funding Information: The work was financially supported by a Russian Science Foundation Grant (Project No. 18-13-00361). We thank the Khimiya Common Use Center, NIOCh, SB, RAS, for the spectral and analytical studies. Publisher Copyright: © 2022, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/9
Y1 - 2022/9
N2 - Cross-coupling of 8-bromocaffeine, 8-bromo-1-butyltheobromine, or 8-bromo-7-butyltheophylline with α-, β-, or ω-amino-acid methyl or t-butyl ester hydrochlorides in toluene in the presence of the catalytic system Pd(OAc)2·XantPhos and Cs2CO3 with microwave activation led to the formation of xanthine derivatives containing amino-acid fragments in the C-8 position. The antibacterial activity against Staphylococcus aureus and Bacillus cereus was studied.
AB - Cross-coupling of 8-bromocaffeine, 8-bromo-1-butyltheobromine, or 8-bromo-7-butyltheophylline with α-, β-, or ω-amino-acid methyl or t-butyl ester hydrochlorides in toluene in the presence of the catalytic system Pd(OAc)2·XantPhos and Cs2CO3 with microwave activation led to the formation of xanthine derivatives containing amino-acid fragments in the C-8 position. The antibacterial activity against Staphylococcus aureus and Bacillus cereus was studied.
KW - amino acids
KW - antibacterial activity
KW - caffeine
KW - catalytic amination
KW - xanthines
UR - http://www.scopus.com/inward/record.url?scp=85138724857&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/7f6ce8da-a827-35a8-a1e7-99b996dff72c/
U2 - 10.1007/s10600-022-03826-3
DO - 10.1007/s10600-022-03826-3
M3 - Article
AN - SCOPUS:85138724857
VL - 58
SP - 908
EP - 915
JO - Chemistry of Natural Compounds
JF - Chemistry of Natural Compounds
SN - 0009-3130
IS - 5
ER -
ID: 38047591