TY - JOUR

T1 - Suppression mediates the effect of 5-HTTLPR by stress interaction on depression

AU - Knyazev, Gennady G.

AU - Bazovkina, Daria V.

AU - Savostyanov, Alexander N.

AU - Naumenko, Vladimir S.

AU - Kuznetsova, Valeriya B.

AU - Proshina, Ekaterina A.

N1 - Publisher Copyright: © 2017 Scandinavian Psychological Associations and John Wiley & Sons Ltd Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - A number of studies have shown that the presence of short (S), as opposed to long (L), allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) is associated with a higher risk for depression following exposure to stressful life events. However, many other studies failed to confirm this association. One reason for this inconsistency might be the fact that the interaction of the 5-HTTLPR polymorphism with stress may relate not to depression per se, but rather to adaptive or maladaptive emotion regulation strategies. Here we show that individuals homozygous for the long allele respond to stressful events by reappraising their emotional meaning, which may hamper the harmful effect of stress on mental health. In S genotype carriers, on the other hand, stress triggers the appearance of intrusive thoughts and vain attempts to suppress them, which in this group acts as a mediator between stress and depressive symptoms. These findings are in line with neuroimaging studies showing that 5-HTTLPR polymorphism has an effect on the connectivity among key areas involved in emotion regulation.

AB - A number of studies have shown that the presence of short (S), as opposed to long (L), allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) is associated with a higher risk for depression following exposure to stressful life events. However, many other studies failed to confirm this association. One reason for this inconsistency might be the fact that the interaction of the 5-HTTLPR polymorphism with stress may relate not to depression per se, but rather to adaptive or maladaptive emotion regulation strategies. Here we show that individuals homozygous for the long allele respond to stressful events by reappraising their emotional meaning, which may hamper the harmful effect of stress on mental health. In S genotype carriers, on the other hand, stress triggers the appearance of intrusive thoughts and vain attempts to suppress them, which in this group acts as a mediator between stress and depressive symptoms. These findings are in line with neuroimaging studies showing that 5-HTTLPR polymorphism has an effect on the connectivity among key areas involved in emotion regulation.

KW - 5-HTTLPR

KW - depression

KW - emotion regulation

KW - reappraisal

KW - rumination

KW - stress

KW - suppression

KW - Stress, Psychological/complications

KW - Humans

KW - Genotype

KW - Male

KW - Depression/complications

KW - Emotions

KW - Polymorphism, Genetic

KW - Homozygote

KW - Serotonin Plasma Membrane Transport Proteins/genetics

KW - Alleles

KW - Adult

KW - Female

UR - http://www.scopus.com/inward/record.url?scp=85029218788&partnerID=8YFLogxK

UR - https://www.elibrary.ru/item.asp?id=31035973

U2 - 10.1111/sjop.12389

DO - 10.1111/sjop.12389

M3 - Article

C2 - 28901577

AN - SCOPUS:85029218788

VL - 58

SP - 373

EP - 378

JO - Scandinavian Journal of Psychology

JF - Scandinavian Journal of Psychology

SN - 0036-5564

IS - 5

ER -