Research output: Contribution to journal › Article › peer-review
Suppression mediates the effect of 5-HTTLPR by stress interaction on depression. / Knyazev, Gennady G.; Bazovkina, Daria V.; Savostyanov, Alexander N. et al.
In: Scandinavian Journal of Psychology, Vol. 58, No. 5, 01.10.2017, p. 373-378.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Suppression mediates the effect of 5-HTTLPR by stress interaction on depression
AU - Knyazev, Gennady G.
AU - Bazovkina, Daria V.
AU - Savostyanov, Alexander N.
AU - Naumenko, Vladimir S.
AU - Kuznetsova, Valeriya B.
AU - Proshina, Ekaterina A.
N1 - Publisher Copyright: © 2017 Scandinavian Psychological Associations and John Wiley & Sons Ltd Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - A number of studies have shown that the presence of short (S), as opposed to long (L), allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) is associated with a higher risk for depression following exposure to stressful life events. However, many other studies failed to confirm this association. One reason for this inconsistency might be the fact that the interaction of the 5-HTTLPR polymorphism with stress may relate not to depression per se, but rather to adaptive or maladaptive emotion regulation strategies. Here we show that individuals homozygous for the long allele respond to stressful events by reappraising their emotional meaning, which may hamper the harmful effect of stress on mental health. In S genotype carriers, on the other hand, stress triggers the appearance of intrusive thoughts and vain attempts to suppress them, which in this group acts as a mediator between stress and depressive symptoms. These findings are in line with neuroimaging studies showing that 5-HTTLPR polymorphism has an effect on the connectivity among key areas involved in emotion regulation.
AB - A number of studies have shown that the presence of short (S), as opposed to long (L), allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) is associated with a higher risk for depression following exposure to stressful life events. However, many other studies failed to confirm this association. One reason for this inconsistency might be the fact that the interaction of the 5-HTTLPR polymorphism with stress may relate not to depression per se, but rather to adaptive or maladaptive emotion regulation strategies. Here we show that individuals homozygous for the long allele respond to stressful events by reappraising their emotional meaning, which may hamper the harmful effect of stress on mental health. In S genotype carriers, on the other hand, stress triggers the appearance of intrusive thoughts and vain attempts to suppress them, which in this group acts as a mediator between stress and depressive symptoms. These findings are in line with neuroimaging studies showing that 5-HTTLPR polymorphism has an effect on the connectivity among key areas involved in emotion regulation.
KW - 5-HTTLPR
KW - depression
KW - emotion regulation
KW - reappraisal
KW - rumination
KW - stress
KW - suppression
KW - Stress, Psychological/complications
KW - Humans
KW - Genotype
KW - Male
KW - Depression/complications
KW - Emotions
KW - Polymorphism, Genetic
KW - Homozygote
KW - Serotonin Plasma Membrane Transport Proteins/genetics
KW - Alleles
KW - Adult
KW - Female
UR - http://www.scopus.com/inward/record.url?scp=85029218788&partnerID=8YFLogxK
UR - https://www.elibrary.ru/item.asp?id=31035973
U2 - 10.1111/sjop.12389
DO - 10.1111/sjop.12389
M3 - Article
C2 - 28901577
AN - SCOPUS:85029218788
VL - 58
SP - 373
EP - 378
JO - Scandinavian Journal of Psychology
JF - Scandinavian Journal of Psychology
SN - 0036-5564
IS - 5
ER -
ID: 9410330