Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › глава/раздел › научная › Рецензирование
Successful Use of Phage and Antibiotics Therapy for the Eradication of Two Bacterial Pathogens from the Respiratory Tract of an Infant. / Morozova, Vera V; Kozlova, Yulia N; Tikunova, Nina V.
Methods in Molecular Biology. ред. / Joana Azeredo; Sanna Sillankorva. Том 2734 2. ред. Humana Press, 2024. стр. 237-243 (Methods in molecular biology (Clifton, N.J.)).Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › глава/раздел › научная › Рецензирование
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TY - CHAP
T1 - Successful Use of Phage and Antibiotics Therapy for the Eradication of Two Bacterial Pathogens from the Respiratory Tract of an Infant
AU - Morozova, Vera V
AU - Kozlova, Yulia N
AU - Tikunova, Nina V
N1 - This work was supported by the Russian state-funded project for ICBFM SB RAS (grant number 121031300043-8). © 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2024
Y1 - 2024
N2 - Phage therapy can be a useful approach in a number of clinical cases associated with multidrug-resistant (MDR) bacterial infections. In this study, we describe a successful consecutive phage and antibiotic application to cure a 3-month-old girl suffering from severe bronchitis after tracheostomy. Bronchitis was associated with two bacterial agents, MDR Pseudomonas aeruginosa and a rare opportunistic pathogen Dolosigranulum pigrum. The phage cocktail "Pyobacteriophage" containing at least two different phages against isolated MDR P. aeruginosa strain was used via inhalation and nasal drops. Topical application of the phage cocktail removed most of P. aeruginosa cells and contributed to a change in the antimicrobial resistance profile of surviving P. aeruginosa cells. As a result, it became possible to choose and administer an appropriate antibiotic that was effective against both infectious agents. Complete recovery of the infant was recorded.
AB - Phage therapy can be a useful approach in a number of clinical cases associated with multidrug-resistant (MDR) bacterial infections. In this study, we describe a successful consecutive phage and antibiotic application to cure a 3-month-old girl suffering from severe bronchitis after tracheostomy. Bronchitis was associated with two bacterial agents, MDR Pseudomonas aeruginosa and a rare opportunistic pathogen Dolosigranulum pigrum. The phage cocktail "Pyobacteriophage" containing at least two different phages against isolated MDR P. aeruginosa strain was used via inhalation and nasal drops. Topical application of the phage cocktail removed most of P. aeruginosa cells and contributed to a change in the antimicrobial resistance profile of surviving P. aeruginosa cells. As a result, it became possible to choose and administer an appropriate antibiotic that was effective against both infectious agents. Complete recovery of the infant was recorded.
KW - Dolosigranulum pigrum
KW - Multidrug resistance
KW - Phage therapy
KW - Pseudomonas aeruginosa
KW - Respiratory tract infection
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85179649926&origin=inward&txGid=c65fc6bdedf40b299d1c80af684ae640
UR - https://www.mendeley.com/catalogue/f1ded6a4-aa82-3d7e-84f9-1ed068ad59ae/
U2 - 10.1007/978-1-0716-3523-0_15
DO - 10.1007/978-1-0716-3523-0_15
M3 - Chapter
C2 - 38066373
SN - 978-1-0716-3522-3
VL - 2734
T3 - Methods in molecular biology (Clifton, N.J.)
SP - 237
EP - 243
BT - Methods in Molecular Biology
A2 - Azeredo, Joana
A2 - Sillankorva, Sanna
PB - Humana Press
ER -
ID: 59334798