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Successful Use of Phage and Antibiotics Therapy for the Eradication of Two Bacterial Pathogens from the Respiratory Tract of an Infant. / Morozova, Vera V; Kozlova, Yulia N; Tikunova, Nina V.

Methods in Molecular Biology. ed. / Joana Azeredo; Sanna Sillankorva. Vol. 2734 2. ed. Humana Press, 2024. p. 237-243 (Methods in molecular biology (Clifton, N.J.)).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review

Harvard

Morozova, VV, Kozlova, YN & Tikunova, NV 2024, Successful Use of Phage and Antibiotics Therapy for the Eradication of Two Bacterial Pathogens from the Respiratory Tract of an Infant. in J Azeredo & S Sillankorva (eds), Methods in Molecular Biology. 2 edn, vol. 2734, Methods in molecular biology (Clifton, N.J.), Humana Press, pp. 237-243. https://doi.org/10.1007/978-1-0716-3523-0_15

APA

Morozova, V. V., Kozlova, Y. N., & Tikunova, N. V. (2024). Successful Use of Phage and Antibiotics Therapy for the Eradication of Two Bacterial Pathogens from the Respiratory Tract of an Infant. In J. Azeredo, & S. Sillankorva (Eds.), Methods in Molecular Biology (2 ed., Vol. 2734, pp. 237-243). (Methods in molecular biology (Clifton, N.J.)). Humana Press. https://doi.org/10.1007/978-1-0716-3523-0_15

Vancouver

Morozova VV, Kozlova YN, Tikunova NV. Successful Use of Phage and Antibiotics Therapy for the Eradication of Two Bacterial Pathogens from the Respiratory Tract of an Infant. In Azeredo J, Sillankorva S, editors, Methods in Molecular Biology. 2 ed. Vol. 2734. Humana Press. 2024. p. 237-243. (Methods in molecular biology (Clifton, N.J.)). Epub 2023 Dec 9. doi: 10.1007/978-1-0716-3523-0_15

Author

Morozova, Vera V ; Kozlova, Yulia N ; Tikunova, Nina V. / Successful Use of Phage and Antibiotics Therapy for the Eradication of Two Bacterial Pathogens from the Respiratory Tract of an Infant. Methods in Molecular Biology. editor / Joana Azeredo ; Sanna Sillankorva. Vol. 2734 2. ed. Humana Press, 2024. pp. 237-243 (Methods in molecular biology (Clifton, N.J.)).

BibTeX

@inbook{5eb126e785f44abeadf450dee49aeea7,
title = "Successful Use of Phage and Antibiotics Therapy for the Eradication of Two Bacterial Pathogens from the Respiratory Tract of an Infant",
abstract = "Phage therapy can be a useful approach in a number of clinical cases associated with multidrug-resistant (MDR) bacterial infections. In this study, we describe a successful consecutive phage and antibiotic application to cure a 3-month-old girl suffering from severe bronchitis after tracheostomy. Bronchitis was associated with two bacterial agents, MDR Pseudomonas aeruginosa and a rare opportunistic pathogen Dolosigranulum pigrum. The phage cocktail {"}Pyobacteriophage{"} containing at least two different phages against isolated MDR P. aeruginosa strain was used via inhalation and nasal drops. Topical application of the phage cocktail removed most of P. aeruginosa cells and contributed to a change in the antimicrobial resistance profile of surviving P. aeruginosa cells. As a result, it became possible to choose and administer an appropriate antibiotic that was effective against both infectious agents. Complete recovery of the infant was recorded.",
keywords = "Dolosigranulum pigrum, Multidrug resistance, Phage therapy, Pseudomonas aeruginosa, Respiratory tract infection",
author = "Morozova, {Vera V} and Kozlova, {Yulia N} and Tikunova, {Nina V}",
note = "This work was supported by the Russian state-funded project for ICBFM SB RAS (grant number 121031300043-8). {\textcopyright} 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2024",
doi = "10.1007/978-1-0716-3523-0_15",
language = "English",
isbn = "978-1-0716-3522-3",
volume = "2734",
series = "Methods in molecular biology (Clifton, N.J.)",
publisher = "Humana Press",
pages = "237--243",
editor = "Joana Azeredo and Sanna Sillankorva",
booktitle = "Methods in Molecular Biology",
address = "United States",
edition = "2",

}

RIS

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T1 - Successful Use of Phage and Antibiotics Therapy for the Eradication of Two Bacterial Pathogens from the Respiratory Tract of an Infant

AU - Morozova, Vera V

AU - Kozlova, Yulia N

AU - Tikunova, Nina V

N1 - This work was supported by the Russian state-funded project for ICBFM SB RAS (grant number 121031300043-8). © 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2024

Y1 - 2024

N2 - Phage therapy can be a useful approach in a number of clinical cases associated with multidrug-resistant (MDR) bacterial infections. In this study, we describe a successful consecutive phage and antibiotic application to cure a 3-month-old girl suffering from severe bronchitis after tracheostomy. Bronchitis was associated with two bacterial agents, MDR Pseudomonas aeruginosa and a rare opportunistic pathogen Dolosigranulum pigrum. The phage cocktail "Pyobacteriophage" containing at least two different phages against isolated MDR P. aeruginosa strain was used via inhalation and nasal drops. Topical application of the phage cocktail removed most of P. aeruginosa cells and contributed to a change in the antimicrobial resistance profile of surviving P. aeruginosa cells. As a result, it became possible to choose and administer an appropriate antibiotic that was effective against both infectious agents. Complete recovery of the infant was recorded.

AB - Phage therapy can be a useful approach in a number of clinical cases associated with multidrug-resistant (MDR) bacterial infections. In this study, we describe a successful consecutive phage and antibiotic application to cure a 3-month-old girl suffering from severe bronchitis after tracheostomy. Bronchitis was associated with two bacterial agents, MDR Pseudomonas aeruginosa and a rare opportunistic pathogen Dolosigranulum pigrum. The phage cocktail "Pyobacteriophage" containing at least two different phages against isolated MDR P. aeruginosa strain was used via inhalation and nasal drops. Topical application of the phage cocktail removed most of P. aeruginosa cells and contributed to a change in the antimicrobial resistance profile of surviving P. aeruginosa cells. As a result, it became possible to choose and administer an appropriate antibiotic that was effective against both infectious agents. Complete recovery of the infant was recorded.

KW - Dolosigranulum pigrum

KW - Multidrug resistance

KW - Phage therapy

KW - Pseudomonas aeruginosa

KW - Respiratory tract infection

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U2 - 10.1007/978-1-0716-3523-0_15

DO - 10.1007/978-1-0716-3523-0_15

M3 - Chapter

C2 - 38066373

SN - 978-1-0716-3522-3

VL - 2734

T3 - Methods in molecular biology (Clifton, N.J.)

SP - 237

EP - 243

BT - Methods in Molecular Biology

A2 - Azeredo, Joana

A2 - Sillankorva, Sanna

PB - Humana Press

ER -

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