Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats

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Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats. / Khvostov, Mikhail Vladimirovich; Chernonosov, Alexander Anatolievich; Borisov, Sergey Alkisovich и др.

в: Therapeutic Delivery, Том 12, № 2, 02.2021, стр. 119-131.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Khvostov, MV, Chernonosov, AA, Borisov, SA, Borisova, MS, Meteleva, ES, Evseenko, VI, Polyakov, NE, Dushkin, AV & Tolstikova, TG 2021, 'Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats', Therapeutic Delivery, Том. 12, № 2, стр. 119-131. https://doi.org/10.4155/tde-2020-0115

APA

Khvostov, M. V., Chernonosov, A. A., Borisov, S. A., Borisova, M. S., Meteleva, E. S., Evseenko, V. I., Polyakov, N. E., Dushkin, A. V., & Tolstikova, T. G. (2021). Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats. Therapeutic Delivery, 12(2), 119-131. https://doi.org/10.4155/tde-2020-0115

Vancouver

Khvostov MV, Chernonosov AA, Borisov SA, Borisova MS, Meteleva ES, Evseenko VI и др. Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats. Therapeutic Delivery. 2021 февр.;12(2):119-131. doi: 10.4155/tde-2020-0115

Author

Khvostov, Mikhail Vladimirovich ; Chernonosov, Alexander Anatolievich ; Borisov, Sergey Alkisovich и др. / Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats. в: Therapeutic Delivery. 2021 ; Том 12, № 2. стр. 119-131.

BibTeX

@article{5f99f24876c846409e9c350b6987c16e,

title = "Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats",

abstract = "Aim: Physicochemical and pharmacological study of the supramolecular inclusion complexes of the hypotensive drug nifedipine (NF) with the larch polysaccharide arabinogalactan (AG). Materials & methods: The NF:AG complexes were obtained and their physicochemical properties were studied. Their hypotensive action and pharmacokinetic profiles were evaluated in rats with normal and elevated arterial blood pressure. Results: In both rat lines the NF:AG complex decreased the arterial blood pressure at a lower dose than free NF (1.75 mg/kg of NF in complex compared with 3.5 mg/kg of free NF) and has a better pharmacokinetic profile than free NF. Conclusion: The use of the NF:AG complex is an effective way to sufficiently enhance and hasten NF's hypotensive action. ",

keywords = "arabinogalactan, bioavailability, complexes, drug delivery, mechanochemistry, nifedipine",

author = "Khvostov, {Mikhail Vladimirovich} and Chernonosov, {Alexander Anatolievich} and Borisov, {Sergey Alkisovich} and Borisova, {Marina Sergeevna} and Meteleva, {Elizaveta Sergeevna} and Evseenko, {Veronika Ivanovna} and Polyakov, {Nikolay Eduardovich} and Dushkin, {Alexander Valerievich} and Tolstikova, {Tatjana Genrihovna}",

year = "2021",

month = feb,

doi = "10.4155/tde-2020-0115",

language = "English",

volume = "12",

pages = "119--131",

journal = "Therapeutic Delivery",

issn = "2041-5990",

publisher = "Future Science",

number = "2",

}

RIS

TY - JOUR

T1 - Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats

AU - Khvostov, Mikhail Vladimirovich

AU - Chernonosov, Alexander Anatolievich

AU - Borisov, Sergey Alkisovich

AU - Borisova, Marina Sergeevna

AU - Meteleva, Elizaveta Sergeevna

AU - Evseenko, Veronika Ivanovna

AU - Polyakov, Nikolay Eduardovich

AU - Dushkin, Alexander Valerievich

AU - Tolstikova, Tatjana Genrihovna

PY - 2021/2

Y1 - 2021/2

N2 - Aim: Physicochemical and pharmacological study of the supramolecular inclusion complexes of the hypotensive drug nifedipine (NF) with the larch polysaccharide arabinogalactan (AG). Materials & methods: The NF:AG complexes were obtained and their physicochemical properties were studied. Their hypotensive action and pharmacokinetic profiles were evaluated in rats with normal and elevated arterial blood pressure. Results: In both rat lines the NF:AG complex decreased the arterial blood pressure at a lower dose than free NF (1.75 mg/kg of NF in complex compared with 3.5 mg/kg of free NF) and has a better pharmacokinetic profile than free NF. Conclusion: The use of the NF:AG complex is an effective way to sufficiently enhance and hasten NF's hypotensive action.

AB - Aim: Physicochemical and pharmacological study of the supramolecular inclusion complexes of the hypotensive drug nifedipine (NF) with the larch polysaccharide arabinogalactan (AG). Materials & methods: The NF:AG complexes were obtained and their physicochemical properties were studied. Their hypotensive action and pharmacokinetic profiles were evaluated in rats with normal and elevated arterial blood pressure. Results: In both rat lines the NF:AG complex decreased the arterial blood pressure at a lower dose than free NF (1.75 mg/kg of NF in complex compared with 3.5 mg/kg of free NF) and has a better pharmacokinetic profile than free NF. Conclusion: The use of the NF:AG complex is an effective way to sufficiently enhance and hasten NF's hypotensive action.

KW - arabinogalactan

KW - bioavailability

KW - complexes

KW - drug delivery

KW - mechanochemistry

KW - nifedipine

UR - http://www.scopus.com/inward/record.url?scp=85101294588&partnerID=8YFLogxK

U2 - 10.4155/tde-2020-0115

DO - 10.4155/tde-2020-0115

M3 - Article

C2 - 33567879

AN - SCOPUS:85101294588

VL - 12

SP - 119

EP - 131

JO - Therapeutic Delivery

JF - Therapeutic Delivery

SN - 2041-5990

IS - 2

ER -

ID: 27967034