Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats

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Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats. / Khvostov, Mikhail Vladimirovich; Chernonosov, Alexander Anatolievich; Borisov, Sergey Alkisovich et al.

In: Therapeutic Delivery, Vol. 12, No. 2, 02.2021, p. 119-131.

Research output: Contribution to journal › Article › peer-review

Harvard

Khvostov, MV, Chernonosov, AA, Borisov, SA, Borisova, MS, Meteleva, ES, Evseenko, VI, Polyakov, NE, Dushkin, AV & Tolstikova, TG 2021, 'Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats', Therapeutic Delivery, vol. 12, no. 2, pp. 119-131. https://doi.org/10.4155/tde-2020-0115

APA

Khvostov, M. V., Chernonosov, A. A., Borisov, S. A., Borisova, M. S., Meteleva, E. S., Evseenko, V. I., Polyakov, N. E., Dushkin, A. V., & Tolstikova, T. G. (2021). Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats. Therapeutic Delivery, 12(2), 119-131. https://doi.org/10.4155/tde-2020-0115

Vancouver

Khvostov MV, Chernonosov AA, Borisov SA, Borisova MS, Meteleva ES, Evseenko VI et al. Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats. Therapeutic Delivery. 2021 Feb;12(2):119-131. doi: 10.4155/tde-2020-0115

Author

Khvostov, Mikhail Vladimirovich ; Chernonosov, Alexander Anatolievich ; Borisov, Sergey Alkisovich et al. / Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats. In: Therapeutic Delivery. 2021 ; Vol. 12, No. 2. pp. 119-131.

BibTeX

@article{5f99f24876c846409e9c350b6987c16e,

title = "Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats",

abstract = "Aim: Physicochemical and pharmacological study of the supramolecular inclusion complexes of the hypotensive drug nifedipine (NF) with the larch polysaccharide arabinogalactan (AG). Materials & methods: The NF:AG complexes were obtained and their physicochemical properties were studied. Their hypotensive action and pharmacokinetic profiles were evaluated in rats with normal and elevated arterial blood pressure. Results: In both rat lines the NF:AG complex decreased the arterial blood pressure at a lower dose than free NF (1.75 mg/kg of NF in complex compared with 3.5 mg/kg of free NF) and has a better pharmacokinetic profile than free NF. Conclusion: The use of the NF:AG complex is an effective way to sufficiently enhance and hasten NF's hypotensive action. ",

keywords = "arabinogalactan, bioavailability, complexes, drug delivery, mechanochemistry, nifedipine",

author = "Khvostov, {Mikhail Vladimirovich} and Chernonosov, {Alexander Anatolievich} and Borisov, {Sergey Alkisovich} and Borisova, {Marina Sergeevna} and Meteleva, {Elizaveta Sergeevna} and Evseenko, {Veronika Ivanovna} and Polyakov, {Nikolay Eduardovich} and Dushkin, {Alexander Valerievich} and Tolstikova, {Tatjana Genrihovna}",

year = "2021",

month = feb,

doi = "10.4155/tde-2020-0115",

language = "English",

volume = "12",

pages = "119--131",

journal = "Therapeutic Delivery",

issn = "2041-5990",

publisher = "Future Science",

number = "2",

}

RIS

TY - JOUR

T1 - Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats

AU - Khvostov, Mikhail Vladimirovich

AU - Chernonosov, Alexander Anatolievich

AU - Borisov, Sergey Alkisovich

AU - Borisova, Marina Sergeevna

AU - Meteleva, Elizaveta Sergeevna

AU - Evseenko, Veronika Ivanovna

AU - Polyakov, Nikolay Eduardovich

AU - Dushkin, Alexander Valerievich

AU - Tolstikova, Tatjana Genrihovna

PY - 2021/2

Y1 - 2021/2

N2 - Aim: Physicochemical and pharmacological study of the supramolecular inclusion complexes of the hypotensive drug nifedipine (NF) with the larch polysaccharide arabinogalactan (AG). Materials & methods: The NF:AG complexes were obtained and their physicochemical properties were studied. Their hypotensive action and pharmacokinetic profiles were evaluated in rats with normal and elevated arterial blood pressure. Results: In both rat lines the NF:AG complex decreased the arterial blood pressure at a lower dose than free NF (1.75 mg/kg of NF in complex compared with 3.5 mg/kg of free NF) and has a better pharmacokinetic profile than free NF. Conclusion: The use of the NF:AG complex is an effective way to sufficiently enhance and hasten NF's hypotensive action.

AB - Aim: Physicochemical and pharmacological study of the supramolecular inclusion complexes of the hypotensive drug nifedipine (NF) with the larch polysaccharide arabinogalactan (AG). Materials & methods: The NF:AG complexes were obtained and their physicochemical properties were studied. Their hypotensive action and pharmacokinetic profiles were evaluated in rats with normal and elevated arterial blood pressure. Results: In both rat lines the NF:AG complex decreased the arterial blood pressure at a lower dose than free NF (1.75 mg/kg of NF in complex compared with 3.5 mg/kg of free NF) and has a better pharmacokinetic profile than free NF. Conclusion: The use of the NF:AG complex is an effective way to sufficiently enhance and hasten NF's hypotensive action.

KW - arabinogalactan

KW - bioavailability

KW - complexes

KW - drug delivery

KW - mechanochemistry

KW - nifedipine

UR - http://www.scopus.com/inward/record.url?scp=85101294588&partnerID=8YFLogxK

U2 - 10.4155/tde-2020-0115

DO - 10.4155/tde-2020-0115

M3 - Article

C2 - 33567879

AN - SCOPUS:85101294588

VL - 12

SP - 119

EP - 131

JO - Therapeutic Delivery

JF - Therapeutic Delivery

SN - 2041-5990

IS - 2

ER -

ID: 27967034