Study of glycemic variability in pregnant women with gestational diabetes: Correlation between maternal clinical and laboratory findings and fetal ultrasound parameters

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Study of glycemic variability in pregnant women with gestational diabetes: Correlation between maternal clinical and laboratory findings and fetal ultrasound parameters. / Zimina, Natalya D.; Mitselya, Elena V.; Samoilova, Yulia G. и др.

в: Voprosy Ginekologii, Akusherstva i Perinatologii, Том 24, № 5, 3, 2025, стр. 27-31.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{5057e042043548f9b40b3c4de6500869,

title = "Study of glycemic variability in pregnant women with gestational diabetes: Correlation between maternal clinical and laboratory findings and fetal ultrasound parameters",

abstract = "Objective. To determine the correlation between glycemic variability (GV) in pregnant women with gestational diabetes (GD) and fetal parameters to identify factors affecting perinatal outcomes. Patients and methods. The study included 50 patients with GD who were fitted with a FreeStyle Libre 2 continuous glucose monitoring sensor. Fetal ultrasound was performed at 30 weeks{\textquoteright} gestation or later. Results. A correlation was found between certain clinical and laboratory parameters in pregnant women with GD and serum GV: A negative correlation between total bilirubin and time in range (TIR) (%) (R = -0.386, p = 0.049) indicated a tendency for TIR to decrease with increasing bilirubin levels, and a decrease in mean glucose levels (mmol/L) was observed with increasing maternal height (R = -0.338, p = 0.044) and fetal femur length (R = -0.491, p = 0.009). Correlations between maternal height and estimated glycated hemoglobin levels (%) (R = -0.339, p = 0.042) and femur length (R = -0.503, p = 0.007) were also significant. Furthermore, there was a correlation between maternal height and the percentage of GV (R = -0.438, p = 0.0322) and cholesterol levels (R = -0.394, p = 0.046). High cholesterol and femur length correlated with an increase in cases where glucose levels were below the target range (R = -0.583, p = 0.001 and R = -0.606, p = 0.047, respectively). Conclusion. There are significant correlations between GV and certain maternal clinical and laboratory findings, as well as fetal ultrasound parameters.",

keywords = "Diabetic fetopathy, Gestational diabetes, Glycemic variability, Perinatal outcomes, Pregnancy risks, Ultrasound diagnosis, УЛЬТРАЗВУКОВАЯ ДИАГНОСТИКА, ДИАБЕТИЧЕСКАЯ ФЕТОПАТИЯ, ВАРИАБЕЛЬНОСТЬ ГЛЮКОЗЫ, ГЕСТАЦИОННЫЙ САХАРНЫЙ ДИАБЕТ, РИСКИ БЕРЕМЕННОСТИ, ПЕРИНАТАЛЬНЫЕ ИСХОДЫ",

author = "Zimina, {Natalya D.} and Mitselya, {Elena V.} and Samoilova, {Yulia G.} and Kudlay, {Dmitry A.} and Fomina, {Svetlana V.}",

note = "Исследование вариабельности глюкозы у беременных с гестационным сахарным диабетом: корреляция клинико-лабораторных данных матери и ультразвуковых параметров плода / Н.Д. Зимина, Е.В. Мицеля, Ю.Г. Самойлова, Д.А. Кудлай, С.В. Фомина // Вопросы гинекологии, акушерства и перинатологии. – 2025. – Т. 24. - № 5. – С. 27-31. – DOI 10.20953/1726-1678-2025-5-27-31. – EDN NONMPV.",

year = "2025",

doi = "10.20953/1726-1678-2025-5-27-31",

language = "English",

volume = "24",

pages = "27--31",

journal = "Voprosy Ginekologii, Akusherstva i Perinatologii",

issn = "1726-1678",

publisher = "Dynasty Publishing House",

number = "5",

}

RIS

TY - JOUR

T1 - Study of glycemic variability in pregnant women with gestational diabetes: Correlation between maternal clinical and laboratory findings and fetal ultrasound parameters

AU - Zimina, Natalya D.

AU - Mitselya, Elena V.

AU - Samoilova, Yulia G.

AU - Kudlay, Dmitry A.

AU - Fomina, Svetlana V.

N1 - Исследование вариабельности глюкозы у беременных с гестационным сахарным диабетом: корреляция клинико-лабораторных данных матери и ультразвуковых параметров плода / Н.Д. Зимина, Е.В. Мицеля, Ю.Г. Самойлова, Д.А. Кудлай, С.В. Фомина // Вопросы гинекологии, акушерства и перинатологии. – 2025. – Т. 24. - № 5. – С. 27-31. – DOI 10.20953/1726-1678-2025-5-27-31. – EDN NONMPV.

PY - 2025

Y1 - 2025

N2 - Objective. To determine the correlation between glycemic variability (GV) in pregnant women with gestational diabetes (GD) and fetal parameters to identify factors affecting perinatal outcomes. Patients and methods. The study included 50 patients with GD who were fitted with a FreeStyle Libre 2 continuous glucose monitoring sensor. Fetal ultrasound was performed at 30 weeks’ gestation or later. Results. A correlation was found between certain clinical and laboratory parameters in pregnant women with GD and serum GV: A negative correlation between total bilirubin and time in range (TIR) (%) (R = -0.386, p = 0.049) indicated a tendency for TIR to decrease with increasing bilirubin levels, and a decrease in mean glucose levels (mmol/L) was observed with increasing maternal height (R = -0.338, p = 0.044) and fetal femur length (R = -0.491, p = 0.009). Correlations between maternal height and estimated glycated hemoglobin levels (%) (R = -0.339, p = 0.042) and femur length (R = -0.503, p = 0.007) were also significant. Furthermore, there was a correlation between maternal height and the percentage of GV (R = -0.438, p = 0.0322) and cholesterol levels (R = -0.394, p = 0.046). High cholesterol and femur length correlated with an increase in cases where glucose levels were below the target range (R = -0.583, p = 0.001 and R = -0.606, p = 0.047, respectively). Conclusion. There are significant correlations between GV and certain maternal clinical and laboratory findings, as well as fetal ultrasound parameters.

AB - Objective. To determine the correlation between glycemic variability (GV) in pregnant women with gestational diabetes (GD) and fetal parameters to identify factors affecting perinatal outcomes. Patients and methods. The study included 50 patients with GD who were fitted with a FreeStyle Libre 2 continuous glucose monitoring sensor. Fetal ultrasound was performed at 30 weeks’ gestation or later. Results. A correlation was found between certain clinical and laboratory parameters in pregnant women with GD and serum GV: A negative correlation between total bilirubin and time in range (TIR) (%) (R = -0.386, p = 0.049) indicated a tendency for TIR to decrease with increasing bilirubin levels, and a decrease in mean glucose levels (mmol/L) was observed with increasing maternal height (R = -0.338, p = 0.044) and fetal femur length (R = -0.491, p = 0.009). Correlations between maternal height and estimated glycated hemoglobin levels (%) (R = -0.339, p = 0.042) and femur length (R = -0.503, p = 0.007) were also significant. Furthermore, there was a correlation between maternal height and the percentage of GV (R = -0.438, p = 0.0322) and cholesterol levels (R = -0.394, p = 0.046). High cholesterol and femur length correlated with an increase in cases where glucose levels were below the target range (R = -0.583, p = 0.001 and R = -0.606, p = 0.047, respectively). Conclusion. There are significant correlations between GV and certain maternal clinical and laboratory findings, as well as fetal ultrasound parameters.

KW - Diabetic fetopathy

KW - Gestational diabetes

KW - Glycemic variability

KW - Perinatal outcomes

KW - Pregnancy risks

KW - Ultrasound diagnosis

KW - УЛЬТРАЗВУКОВАЯ ДИАГНОСТИКА

KW - ДИАБЕТИЧЕСКАЯ ФЕТОПАТИЯ

KW - ВАРИАБЕЛЬНОСТЬ ГЛЮКОЗЫ

KW - ГЕСТАЦИОННЫЙ САХАРНЫЙ ДИАБЕТ

KW - РИСКИ БЕРЕМЕННОСТИ

KW - ПЕРИНАТАЛЬНЫЕ ИСХОДЫ

UR - https://www.scopus.com/pages/publications/105026929703

UR - https://www.elibrary.ru/item.asp?id=84778948

UR - https://www.mendeley.com/catalogue/db75557d-b791-30f6-9d27-c0b48dad5230/

U2 - 10.20953/1726-1678-2025-5-27-31

DO - 10.20953/1726-1678-2025-5-27-31

M3 - Article

VL - 24

SP - 27

EP - 31

JO - Voprosy Ginekologii, Akusherstva i Perinatologii

JF - Voprosy Ginekologii, Akusherstva i Perinatologii

SN - 1726-1678

IS - 5

M1 - 3

ER -

ID: 74323976